anti-Melanoma Inhibitory Activity Protein 2 (MIA2) Antibodies

Human Melanoma Inhibitory Activity Protein 2 (MIA2) interaction partners

1. TANGO1 (show MIA3 Antibodies)/CTAGE5 (show CTAGE5 Antibodies) receptor serves as a polyvalent template for assembly of large COPII coats.

2. In this study, we identified specific and critical residues in the Sec12 (show PREB Antibodies)-binding region of cTAGE5 (show CTAGE5 Antibodies) (E75A K76A, K89A, and S97A) and confirmed that cTAGE5 (show CTAGE5 Antibodies)-mediated Sec12 (show PREB Antibodies) accumulation at ER exit sites is required for collagen VII (show TH Antibodies) secretion.

3. Data indicate that MIA2 represents a potential novel acute phase protein (show ORM1 Antibodies) and MIA2 expression responds to liver damage in chronic liver diseases.

4. The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma.

5. population and bioinformatic analysis of MGEA6 (show CTAGE5 Antibodies) P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings

6. cTAGE5 (show CTAGE5 Antibodies) forms a complex with TANGO1 (MIA3 (show MIA3 Antibodies)), a previously characterized cargo receptor for collagen VII (show TH Antibodies)

7. HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2.

8. 22 members of an Iranian family with basal ganglia calfication as well as 100 controls were genotyped for the C>G P521A variant of CTAGE5 (show CTAGE5 Antibodies), but none were found.

9. Findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase (show MAPK1 Antibodies) in oral carcinoma.

10. Sec12 (show PREB Antibodies) recruitment to endoplasmic reticulum exit sites is organized by its direct interaction with cTAGE5 (show CTAGE5 Antibodies), a previously characterized collagen cargo receptor component, which functions together with TANGO1 (show MIA3 Antibodies) at endoplasmic reticulum exit sites.

Mouse (Murine) Melanoma Inhibitory Activity Protein 2 (MIA2) interaction partners

1. Conditional knockout of cTAGE5/MEA6 (show CTAGE5 Antibodies) in the brain leads to severe defects in neural development, including deficits in dendrite outgrowth and branching, spine formation and maintenance, astrocyte activation, and abnormal behaviors

2. cTAGE5 (show CTAGE5 Antibodies) deletion in pancreatic beta cells impairs proinsulin (show INS Antibodies) trafficking and insulin (show INS Antibodies) biogenesis in mice.

3. Mia2 is a novel, hepatic, endoplasmic reticulum-to-Golgi trafficking protein that regulates cholesterol metabolism.