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MARCH3 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 220.127.116.11). Additionally we are shipping Membrane-Associated Ring Finger (C3HC4) 3, E3 Ubiquitin Protein Ligase Proteins (5) and many more products for this protein.
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Report shows that silencing MARCH3 protects the endothelial barrier and upregulates OCLN in MARCH3-depleted cells. MARCH3 silencing results in the strengthening of cell-cell contacts and inactivates FoxO1.
LPS activation of TLR4 significantly increased MARCH3 expression and that siRNA against MARCH3 prevented the decrease in FcgammaRIIb following LPS treatment.
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway.
E3 ubiquitin-protein ligase MARCH3
, membrane-associated RING finger protein 3
, membrane-associated RING-CH protein III
, RING finger protein 173