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MARCH3 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 126.96.36.199).
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Report shows that silencing MARCH3 protects the endothelial barrier and upregulates OCLN (show OCLN Antibodies) in MARCH3-depleted cells. MARCH3 silencing results in the strengthening of cell-cell contacts and inactivates FoxO1 (show FOXO1 Antibodies).
LPS (show IRF6 Antibodies) activation of TLR4 (show TLR4 Antibodies) significantly increased MARCH3 expression and that siRNA against MARCH3 prevented the decrease in FcgammaRIIb following LPS (show IRF6 Antibodies) treatment.
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway.
E3 ubiquitin-protein ligase MARCH3
, membrane-associated RING finger protein 3
, membrane-associated RING-CH protein III
, RING finger protein 173