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MS4A4A encodes a member of the membrane-spanning 4A gene family.
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MS4A4A is expressed at the plasma membrane in monocytes but not in granulocytes or lymphocytes.
MS4A4A expression is significantly upregulated in human masticatory mucosa during wound healing
MS4A4 in human mast cells effects ligand-induced KIT endocytosis pathways and reduced receptor recycling to the cell surface, thus promoting KIT signaling in the endosomes while reducing that in the plasma membrane.
Single nucleotide polymorphisms in APOE (show APOE Antibodies)-epsilon4, CLU (show CLU Antibodies) and MS4A4A influence both Alzheimer disease risk and cerebrospinal fluid Amyloid-beta1-42 levels.
Common variants at MS4A4/MS4A6E (show MS4A6E Antibodies), CD2AP (show Cd2ap Antibodies), CD33 (show CD33 Antibodies) and EPHA1 (show EPHA1 Antibodies) are associated with late-onset Alzheimer's disease.
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CD20 antigen-like 1
, Fc epsilon receptor beta subunit homolog
, four-span transmembrane protein 1
, membrane-spanning 4-domains subfamily A member 4A
, membrane-spanning 4-domains, subfamily A, member 4