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MS4A6A encodes a member of the membrane-spanning 4A gene family.
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rs610932 MS4A6A is not associated with late-onset Alzheimer's disease.
these findings reveal that MS4A6A genotypes affect Alzheimer's disease specific brain structures
Study found enrichment of epistasis in gonadotropin-releasing hormone signaling with risk single-nucleotide polymorphisms in APOE (show APOE Antibodies) and MS4A6A. Results suggest that in addition to APOE (show APOE Antibodies), MS4A6A polymorphisms should be considered in hormone trials targeting gonadotropins.
identified the significant associations of the GBA (show GBA Antibodies) L444P mutation and DYRK1A (show DYRK1A Antibodies) rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A rs610932 with the delayed AAO of PD.
Common variants in ABCA7 (show ABCA7 Antibodies) and MS4A6A are associated with cortical and hippocampal atrophy.
high levels of MS4A6A contribute to altered turnover or production of cells with an anti-inflammatory neuroprotective phenotype in favor of cells with a damaging pro-inflammatory phenotype believed to contribute to AD pathology.
data revealed the allele (T) of the rs3865444 polymorphism of the CD33 gene and the allele (C) of the rs610932 polymorphism of the MS4A6A gene may contribute to Alzheimer's disease risk in the Chinese Han population
ABCA7 and the MS4A6A/MS4A4E gene cluster are new Alzheimer's disease susceptibility loci.
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms.
CD20 antigen-like 3
, CD20-like precusor
, four-span transmembrane protein 3
, four-span transmembrane protein 3.1
, four-span transmembrane protein 3.2
, membrane-spanning 4-domains subfamily A member 6A
, membrane-spanning 4-domains subfamily A member 6D
, membrane-spanning 4-domains, subfamily A, member 11
, membrane-spanning 4-domains, subfamily A, member 6A