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MFAP4 encodes a protein with similarity to a bovine microfibril-associated protein. Additionally we are shipping MFAP4 Antibodies (78) and MFAP4 Kits (25) and many more products for this protein.
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the applicability of MFAP4 as a novel serum biomarker for assessment of hepatic fibrosis and identification of high-risk patients with severe fibrosis stages in hepatitis C, is reported.
These studies have identified and validated new factors enriched in juvenile chondrocytes as compared to adult chondrocytes including secreted extracellular matrix factors chordin-like 1 (CHRDL1 (show CHRDL1 Proteins)) and microfibrillar-associated protein 4 (MFAP4).
plasma MFAP4 was significantly increased among patients with a previous diagnosis of liver disease or congestive heart failure compared to patients with other diagnoses.
Data suggest that MFAP4 specifically binds tropoelastin (show ELN Proteins) and fibrillin-1 (show FBN1 Proteins)/-2, as well as elastin (show ELN Proteins) cross-linking amino acid desmosine; MFAP4 co-localizes with fibrillin-1 (show FBN1 Proteins)-positive fibers; MFAP4 actively promotes tropoelastin (show ELN Proteins) self-assembly.
MFAP4 regulates integrin alphaVbeta3 (show ITGAV Proteins)-induced VSMC proliferation and migration, as well as monocyte chemotaxis, and accelerates neointimal hyperplasia after vascular injury.
Serum MFAP4 varies in groups of patients with different cardiovascular conditions.
The findings support the biomarker potential of systemic MFAP4, with elevated levels in the serum reflecting pathological processes involving ECM (show MMRN1 Proteins) remodeling and degradation.
skin with enhanced MFAP-4 expression was protected from UVB-induced photodamage/photoaging accompanied by the prevention of ECM (show MMRN1 Proteins) degradation and aggravated elasticity
Microfibrillar associated protein 4 binds pulmonary surfactant protein A (show GPR153 Proteins) (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung.
MFAP4 promotes follicular dendritic cell development in regenerating splenic tissue.
MFAP4 promoted the development of asthmatic airway disease in vivo and pro-asthmatic functions of bronchial smooth muscle cells in vitro
Mfap4 knockout mice develop a spontaneous loss of lung function.
This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene.
microfibril-associated glycoprotein 4
, microfibrillar-associated protein 4
, Microfibril-associated glycoprotein 4
, 36 kDa MAP
, 36 kDa microfibril-associated glycoprotein
, angiopoietin-like 7