Microtubule-Associated Protein 1S Proteins (MAP1S)

Human Microtubule-Associated Protein 1S (MAP1S) interaction partners

1. Results suggested that microtubule associated protein 1S (MAP1S) were up-regulated among Crohn's disease (CD) patients and MAP1S-related autophagy inhibits apoptosis of intestinal epithelial cells (IECs) through Wnt/beta-catenin signaling pathway which might play a vital role in the protection of intestinal mucosal barrier and inhibition the progression of CD.

2. Autophagy defects in the degradation of lipid droplets triggered by the MAP1S deficiency may enhance the initiation and development of ccRCC and reduce the survival of ccRCC patients.

3. HDAC4 destabilizes MAP1S, suppresses autophagy flux and promotes the accumulation of mHTT aggregates.

4. Ddata underline the key role of MAP1S as a global regulator of microbutule stability and demonstrate a new primary function of MAP1S to regulate MT dynamics at the onset of cytokinesis.

5. results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.

6. The PU.1-regulated MAP1S gene is implicated in neutrophil differentiation and autophagy control.

7. clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance.

8. The amino acid sequence of VCY2IP-1 shows 59.3% and 41.9% homology to two human microtubule-associated proteins (MAPs), MAP1B and MAP1A, respectively. VCY2IP-1 has an extensive homology to the N-terminus and C-terminus regions of MAP1B and MAP1A

9. is expressed in a wide range of tissues in addition to neurons and represents the non-neuronal counterpart of a cytolinker family

10. Deletion mutagenesis indicated that C19ORF5 selectively binds double stranded DNA through its microtubule binding domain.

11. These results suggest that the interaction of SOCS3 with MAP1S and the integrity of the microtubule cytoskeleton play an important role in the negative regulation of SOCS3 on IL-6 signaling.

12. C19ORF5 distributed broadly across the mitotic spindle and reversibly accumulated during reversible mitotic arrest.

Mouse (Murine) Microtubule-Associated Protein 1S (MAP1S) interaction partners

1. Depletion of MAP1S in mice leads to an accumulation of fibrosis-related proteins and the development of renal fibrosis in aged mice.

2. MAP1S-mediated autophagy plays an important role in maintaining mouse lifespan especially in the presence of extra amount of fibronectin.

3. Data (including data from studies in knockout mice) suggest that Map1s interacts directly with MyD88 (myeloid differentiation primary response gene 88), a key adaptor of Toll-like receptors, as phagocytosis of bacteria is initiated in macrophages.

4. Data establish a link between MAP1S-enhanced autophagy and suppression of genomic instability and tumorigenesis.

5. clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance.

6. MAP8 is a novel microtubule associated protein containing two microtubule binding domains.

7. Axonal transport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein.