Mitochondrial Fission Factor Proteins (MFF)

Human Mitochondrial Fission Factor (MFF) interaction partners

1. expressions of TIA-1 (show TIA1 Proteins) and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR (show MLXIP Proteins)-200a-3p and miR (show MLXIP Proteins)-27a/b were relatively lower in the cancerous liver tissues

2. We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations

3. membrane-anchored Mff differentially regulates various Drp1 (show CRMP1 Proteins) isoforms.

4. Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC).

5. loss of Mff results in failure of Parkin (show PARK2 Proteins) translocation and final clearance of damaged mitochondria

6. Mitochondrial fission factor (MFF) mRNA is a direct target of miR (show MLXIP Proteins)-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region.

7. MiD49 (show SMCR7 Proteins) and MiD51 (show SMCR7L Proteins) can act independently of Mff and Fis1 (show FIS1 Proteins) in Drp1 (show CRMP1 Proteins) recruitment and suggest that they provide specificity to the division of mitochondria.

8. TRAP1 (show TRAP1 Proteins) controls mitochondrial fusion/fission balance through Drp1 (show CRMP1 Proteins) and Mff expression.

9. PEX11 proteins attract both Mff and human Fis1 (hFis1 (show FIS1 Proteins)) to their site of action.

10. MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS (show ROS1 Proteins) production, and the onset of autophagy and mitophagy.

Mouse (Murine) Mitochondrial Fission Factor (MFF) interaction partners

1. mitochondrial fission factor

2. MiD51 (show SMCR7L Proteins) can suppress Mff-dependent enhancement of Drp1 (show CRMP1 Proteins) GTPase (show RACGAP1 Proteins) activity.

3. Mff cannot bind to assembly-deficient mutants of Drp1 (show CRMP1 Proteins), suggesting that Mff selectively interacts with higher-order complexes of Drp1 (show CRMP1 Proteins).

4. membrane-anchored Mff differentially regulates various Drp1 (show CRMP1 Proteins) isoforms.

5. These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 (show CRMP1 Proteins) regulate their collaborative interaction.

6. Ablating Mfn1 (show MFN1 Proteins) eliminates the cardiac-related lethality of Mff knockout mice.

7. Mitochondrial fission factor has been identified as a new AMPK (show PRKAA1 Proteins) substrate.

8. This study reveals a novel model of mitochondrial fission regulation, which is composed of miR (show MLXIP Proteins)-761 and mitochondrial fission factor

9. MiD49 (show SMCR7 Proteins) and MiD51 (show SMCR7L Proteins) can act independently of Mff and Fis1 (show FIS1 Proteins) in Drp1 (show CRMP1 Proteins) recruitment and suggest that they provide specificity to the division of mitochondria.

10. immunofluorescence analysis of Drp1 (show CRMP1 Proteins) suggests that Fis1 (show FIS1 Proteins) and Mff are important for the number and size of Drp1 (show CRMP1 Proteins) puncta on mitochondria.