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The genotypic polymorphisms of IL-1beta -511 and +3954, and of MUC7 VNTR, had no direct associations with the development of BMS. However, the T allele of IL-1beta -511 may increase the risk of BMS by increasing psychological asthenia.
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High expression of MUC7 is associated with clear-cell renal cell carcinoma.
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A capsule-free mutant of S. pneumoniae TIGR4 binds to salivary proteins, most prominently to mucin MUC7, but that this binding was not mediated through PsrP or recognition of sialic acid.
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MUC7 glycosylation is altered in recurrent aphthous stomatitis. This may change the protective properties of this mucin against mucosal pathogens, which may effect this condition.
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Results identified a reduction in glycosylation of MUC7 in Sjogren's primarily due to the loss of the extended core 2 disialylated structure, with and without fucosylation and suggest that MUC7 O-glycan changes in Sjogren's Syndrome may alter the physical properties of saliva, leading to the symptom of dry mouth.
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The minimally invasive PTT procedure combined with Mucin 7 targeted GNPs is able to kill cancer cells and preserve healthy cells
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MUC7 is a salivary mucin with antimicrobial activity against bacteria and fungi.
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A significant increase in sulfation was identified in salivary MUC7 from rheumatoid arthritis patients.
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The study did not show a correlation between the MUC7 genotypes and caries.
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The present study did not disclose an association between MUC7*5/*6 and MUC7*6/*6 genotypes and gingival bleeding index.
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expression of different numbers of terminal repeats in this salivary mucin in the oral environment does not interfere with the etiopathogenesis of aggressive or chronic periodontitis
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MUC7 expression in ductal adenocarcinoma (DAC) and chronic pancreatitis was not statistically significant, but MUC7 could be considered as potential marker of malignant lesions, especially in pancreatic DAC, as it was positive in 73% of these cases.
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A novel MUC7*5-generated variable number of tandem repeat (VNTR) polymorphism decreases the likelihood of a diagnosis of asthma in an African American population.
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MUC5B and MUC7 from HIV patients, unlike the MUC5B and MUC7 from HIV negative individuals, did not inhibit HIV-1 activity.
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Structure and biosynthesis of human salivary mucins.
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Level of MG2 is lower in saliva of subjects with dental disease
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binds to Streptococcus mutans alpha-enolase [MG2]
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reported as new substrate for StcE protease of Escherichia coli O157-H7 in HEp-2 cells
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Interactions between mucin and non-mucin proteins in saliva could protect complex partners from proteolysis
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When the cells were treated with a panel of cytokines, epidermal growth factor, or a bacterial product (Pseudomonas aeruginosa lipopolysaccharide [LPS]), MUC7 transcripts and glycoprotein products were increased 1.7- to 3.2-fold.
