Protein Summary

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.

Gene names and symbols associated with MRVI1

• MRV integration site 1 (Mrvi1) antibody
• murine retrovirus integration site 1 homolog (MRVI1) antibody

• BB115629 antibody
• IRAG antibody
• JAW1L antibody
• Ris1 antibody

Protein level used designations for MRVI1

JAW1-related protein MRVI1 , inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate , inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate , murine retrovirus integration site 1 protein , protein MRVI1 , retroviral integration site 1 , IP3R-associated cGMP kinase substrate , IP3 receptor associated cGMP kinase substrate