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Induces rhoa activation and activates nppa transcription and myofibrillar organization through the rho/rock signaling pathway (By similarity). Additionally we are shipping MURC Kits (7) and MURC Proteins (7) and many more products for this protein.
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Human Polyclonal MURC Primary Antibody for ICC, IF - ABIN4336750
Tassin, Leroy, Laoudj-Chenivesse, Wauters, Vanderplanck, Le Bihan, Coppée, Wattiez, Belayew: FSHD myotubes with different phenotypes exhibit distinct proteomes. in PLoS ONE 2012
Human Polyclonal MURC Primary Antibody for IHC, IHC (p) - ABIN4336752
Faggi, Codenotti, Poliani, Cominelli, Chiarelli, Colombi, Vezzoli, Monti, Bono, Tulipano, Fiorentini, Zanola, Lo, Parton, Keller, Fanzani: MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line. in PLoS ONE 2015
murcb mutant zebrafish, display impaired swimming capacity, skeletal muscle fibrosis and T-tubule abnormalities during development.
MURC/cavin-4, especially in combination with Cav-3 (show CAV3 Antibodies), may play a consistent role in the differentiation process of rhabdomyosarcoma.
MURC mutations impart loss-of-function effects on MURC functions and probably are causal variants in human dilated cardiomyopathy
MURC modulates RhoA (show RHOA Antibodies) signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias.
MURC binds to Cav1 (show CAV1 Antibodies) and inhibits the association of Cav1 (show CAV1 Antibodies) with the active form of Galpha13 (show GNA13 Antibodies), resulting in the facilitated association of the active form of Galpha13 (show GNA13 Antibodies) with p115RhoGEF (show ARHGEF1 Antibodies). These results reveal that MURC has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling.
The MURC/Cavin-4 in vascular smooth muscle cells modulates abdominal aortic aneurysm (AAA (show AAAS Antibodies)) progression at the early stage via the activation of JNK (show MAPK8 Antibodies) and MMP-9 (show MMP9 Antibodies). MURC/Cavin-4 is a potential therapeutic target against AAA (show AAAS Antibodies) progression.
MURC/Cavin-4 facilitates recruitment of ERK (show EPHB2 Antibodies) to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.
findings suggest that MURC is involved in the skeletal myogenesis that results from modulation of myogenin (show MYOG Antibodies) expression and ERK (show EPHB2 Antibodies) activation; MURC may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation
Data show that MURC/Cavin-4 forms a multiprotein complex that associates with caveolae, and identify Cavin-4 as a novel muscle disease candidate caveolar protein.
Induces rhoa activation and activates nppa transcription and myofibrillar organization through the rho/rock signaling pathway (By similarity).
muscle-related coiled-coil protein
, muscle-restricted coiled-coil protein
, PTRF/SDPR family protein