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May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane (By similarity).. Additionally we are shipping MOBP Antibodies (59) and MOBP Kits (4) and many more products for this protein.
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Mutation in MOBP gene is associated with amyotrophic lateral sclerosis.
rs1768208 is associated with corticobasal degeneration.
The rs1768208 risk polymorphism in MOBP has prognostic value in behavioral-variant frontotemporal dementia.
Genotypes at MOBP and EIF2AK3 confer risk predominantly in APOE epsilon4-positive subjects, with indications of an interaction between APOE and MOBP or EIF2AK3 on Alzheimer's disease risk.
Decreased expression of a number of myelin-related genes, including myelin basic protein (MBP), proteolipid protein (PLP), and myelin-associated oligodendrocyte basic protein (MOBP) was noted in nucleus accumbens of cocaine abusers
MOBP mRNA levels were increased in the DLPFC white matter in patients with a history of substance abuse.
MOBP synthesis is stimulated by Fyn activity.
Mobp is associated with the alcohol-preference genotype in the context of alcohol-preferring, compared to alcohol-avoiding mouse strains.
MOBP-deficient mice develop normally, generate intact compact CNS myelin, and demonstrate no obvious clinical phenotype; absence of MOBP is not simply compensated for by increased expression of the "classic" myelin basic protein (MBP).
Although the Mobp155 and Mobp170 isoforms encode a common predicted C-terminus they have different expression profiles and their products are targeted to mitochondria and the nucleus, respectively, in transiently transfected Cos7 cells.
May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane (By similarity).
Myelin-associated/Oligodendrocytic Basic Protein-81
, myelin-associated oligodendrocytic basic protein
, myelin-associated oligodendrocyte basic protein