Myosin Heavy Chain 11, Smooth Muscle Proteins (MYH11)

The protein encoded by MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. Additionally we are shipping MYH11 Antibodies (88) and MYH11 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse MYH11 MYH11 17880  
MYH11 24582  
MYH11 4629 P35749
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top MYH11 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Rat His tag 100 μg 15 to 18 Days
$720.00
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human MYH11 Protein. 100 μg 11 to 18 Days
$625.39
Details
Yeast Wild boar His tag   1 mg 60 to 71 Days
$2,066.17
Details
Escherichia coli (E. coli) Rat Un-conjugated   100 μg 11 to 18 Days
$596.97
Details

MYH11 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human

More Proteins for Myosin Heavy Chain 11, Smooth Muscle (MYH11) Interaction Partners

Mouse (Murine) Myosin Heavy Chain 11, Smooth Muscle (MYH11) interaction partners

  1. Results indicatethat the defect of smooth muscle myosin heavy chain (SM-MHC) lead to the bladder developing lesions initially at 15.5 dpc stage and also implied that the SM-MHC loss might result in the gas bubbles in stomach.

  2. Force development responses were reduced in aortic tissue from a conditional knockout of smooth muscle myosin heavy chain in adult mice (Myh11+/- or Myh11-/-) with a greater reduction with homozygous vs heterozygous tissues. Similar reductions in force responses were obtained with tissues containing either a heterozygous or homozygous knockin mutation in smooth muscle myosin heavy chain (Myh11+/R247C or Myh11R247C/R247C).

  3. Chd7 deficiency delays leukemia initiation induced by Cbfb-MYH11.

  4. Cbfbeta-SMMHC and Nras(G12D) promote the survival of preleukemic myeloid progenitors primed for leukemia by activation of the MEK/ERK/Bim axis, and define Nras(LSL-G12D); Cbfb(56M) mice as a valuable genetic model for the study of AML therapies.

  5. A rare variant in MYH11, R247C, alters myosin contractile function and smooth muscle cell phenotype, leading to increased proliferation in vitro and in response to vascular injury.

  6. Data show the cooperation between mutated KIT and CBFB-MYH11 during leukemogenesis

  7. Cbfb/Runx1 repression-independent activities contribute to leukemogenesis by Cbfb-MYH11

  8. Myh11 complexes with Cbfb and inhibits the cell cycle.

  9. report the identification of genes that specifically cooperate with CBFB-MYH11 in leukemogenesis

  10. Force dilatation pressure was decreased in smooth muscle B mysoin null mesenteric vessels. (Myosin B))

  11. provides a mechanistic basis for the myeloid-lineage bias of CBFbeta-SMMHC-associated leukemia

  12. Germ line activation of theSMMHC promoters causes noncell-specific deletion of floxed alleles.

  13. Runx2 is expressed in the stem cell compartment, interferes with differentiation and represses CBF targets in the myeloid compartment, and modulates the leukemogenic function of Cbfbeta-SMMHC in mouse leukemia.

Human Myosin Heavy Chain 11, Smooth Muscle (MYH11) interaction partners

  1. Our results show that MYH11 gene harbors somatic frameshift mutations mostly associated with mutational intratumoral heterogeneity , which together may be features of microsatellite instability gastric cancers and colorectal cancers.

  2. Novel variants in the ACTA2 and MYH11 genes was identified in a Cypriot family with thoracic aortic aneurysms.

  3. the presented study demonstrates that CBFB-MYH11-based MRD status during the first 3 months after allo-HCT, but not KIT mutations, can be used to identify patients with a high risk of relapse.

  4. In patients with MYH11 or ACTA2 variants, the effect of intronic variants on splicing was demonstrated on the mRNA level in the induced smooth muscle cell (SMC), allowing classification into pathogenic or nonpathogenic variants.

  5. Deletion mutation in MYH11 gene causing familial Thoracic aortic dissection was identified in two independent Japanese pedigrees.

  6. Data suggest that expression of MYH11, myosin light chain, and MLCK (myosin-light-chain kinase), is up-regulated in uterine myoma as compared to adjacent smooth muscle cells; expression of MYH11 appears to be involved in cell proliferation.

  7. In familial AAA we found one pathogenic and segregating variant (COL3A1 p.Arg491X), one likely pathogenic and segregating (MYH11 p.Arg254Cys), and fifteen VUS.

  8. CBFB contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB-SMMHC in proliferation and maintenance of the leukemic phenotype.

  9. we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation

  10. overexpression of MYH11 can lead to increased ER stress and autophagy

  11. MYH11 gene mutation is associated with family history of thoracic aortic aneurysm dissection.

  12. Transcriptional analysis revealed that upon fusion protein knockdown, a small subset of the CBFbeta-MYH11 target genes show increased expression, confirming a role in transcriptional repression

  13. MYH11 mutations are rare and are identified in patients with thoracic aortic aneurysm/dissection.

  14. Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.

  15. We conclude that non-type A CBFB-MYH11 fusion types associate with distinct clinical and genetic features, including lack of KIT mutations, and a unique gene-expression profile in acute myeloid leukemia

  16. Our data indicate that the CBFbeta-SMMHC's C-terminus is essential to induce embryonic hematopoietic defects and leukemogenesis.

  17. A rare variant in MYH11, R247C, alters myosin contractile function and smooth muscle cell phenotype, leading to increased proliferation in vitro and in response to vascular injury.

  18. Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations.

  19. increased MYH11 expression was found in aortic tissues from TAAD patients with 16p13.1 duplications compared with control aortas.

  20. Data show that the purified hMDCs cultured in SMIM for 4 weeks and expressed significant amount of smooth muscle myosin heavy chain and alpha-smooth muscle actin.

Zebrafish Myosin Heavy Chain 11, Smooth Muscle (MYH11) interaction partners

  1. newly identified missense mutations in the switch-1 (S237Y) and coil-coiled (L1287M) domains of Myh11 fail to complement mlt Cell invasion was not detected in either homozygous mutant but could be induced by oxidative stress and activation of oncogenic signaling pathways.

  2. The mlt mutation constitutively activates the Myh11 ATPase, which disrupts smooth muscle cells surrounding the posterior intestine.

MYH11 Protein Profile

Protein Summary

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16

Gene names and symbols associated with MYH11

  • myosin, heavy polypeptide 11, smooth muscle (Myh11)
  • myosin heavy chain 11 (Myh11)
  • myosin heavy chain 11 (MYH11)
  • myosin, heavy chain 11, smooth muscle (MYH11)
  • myosin, heavy chain 11a, smooth muscle (myh11a)
  • AAT4 protein
  • AV071570 protein
  • FAA4 protein
  • myh11 protein
  • myosin protein
  • SM1 protein
  • SM2 protein
  • SMHC protein
  • SMMHC protein

Protein level used designations for MYH11

myosin heavy chain 11, smooth muscle , myosin heavy chain, smooth muscle isoform , myosin-11 , SMMHC , myosin heavy chain 11 , myosin heavy chain 21 , myosin, heavy polypeptide 11, smooth muscle , smooth muscle myosin heavy chain , MHC , gizzard smooth muscle , heavy polypeptide 11 , myosin heavy chain, gizzard smooth muscle , smooth muscle , myosin heavy chain SMA , meltdown , mlt , myosin, heavy polypeptide 11, smooth muscle a , smmhc , LOW QUALITY PROTEIN: myosin-11 , myosin, heavy chain 11, smooth muscle

GENE ID SPECIES
17880 Mus musculus
24582 Rattus norvegicus
4629 Homo sapiens
396211 Gallus gallus
100009145 Oryctolagus cuniculus
530050 Bos taurus
554168 Danio rerio
479836 Canis lupus familiaris
100627924 Sus scrofa
100714060 Cavia porcellus
Selected quality suppliers for MYH11 Proteins (MYH11)
Did you look for something else?