Myosin Heavy Chain 6, Cardiac Muscle, alpha Proteins (MYH6)

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. Additionally we are shipping Myosin Heavy Chain 6, Cardiac Muscle, alpha Antibodies (42) and Myosin Heavy Chain 6, Cardiac Muscle, alpha Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYH6 29556  
MYH6 4624 P13533
Mouse MYH6 MYH6 17888 Q02566
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Top Myosin Heavy Chain 6, Cardiac Muscle, alpha Proteins at antibodies-online.com

Showing 5 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$752.00
Details
Yeast Human His tag 100 μg Log in to see 8 to 11 Days
$484.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$3,309.17
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
Details

MYH6 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,

More Proteins for Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) Interaction Partners

Human Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Three loci with high mutation frequencies, the 138665410 FOXL2 (show FOXL2 Proteins) gene variant, the 23862952 MYH6 gene variant, and the 71098693 HYDIN gene variant were found to be significantly associated with sporadic Atrial Septal Defect (P<0.05); variants in FOXL2 (show FOXL2 Proteins) and MYH6 were found in patients with isolated, sporadic Atrial Septal Defect (P<5x10-4).

  2. We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes.

  3. The etiology of MYH6-associated HLHS can be informed using iPSCs.

  4. Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1 (show GDF1 Proteins), MYH6, and FLT4 (show FLT4 Proteins) as causative genes.

  5. Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction.

  6. human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other.

  7. The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation.

  8. Data from molecular dynamic/docking simulations suggest that actin-myosin binding free energy accepts contributions from both electrostatic and nonpolar forces; studies compare cardiac alpha-myosin, beta-myosin, and fast skeletal muscle myosin.

  9. R1165C mutation in MYH9 (show MYH9 Proteins) gene is associated with macroscopic hematuria and presenile cataract.

  10. Perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial Secundum-type atrial septal defects.

Mouse (Murine) Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. The stress-induced Brg1 (show SMARCA4 Proteins)-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  2. Data indicate that the cardiac myosin heavy chain alpha isoform (alphaMHC(403)) transgenic model closely recapitulates human disease.

  3. Transfecting human beta-MHC (show MYH7 Proteins) V606M into the mouse cardiac alpha-MHC gene caused hypertrophic cardiomyopathy without left ventricular hypertrophy, disarray of myofibers, and interstitial fibrosis. Cyclosporine or Arg453Cys or Arg719Trp worsened the phenotype.

  4. Mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein (show TNNT2 Proteins) expression.

  5. Results indicate the downstream targets of insulin (show INS Proteins), cyclin D1 (show CCND1 Proteins), BAD, alpha-MHC, and GATA-4 (show GATA4 Proteins), elucidate a molecular mechanism of insulin (show INS Proteins) in promoting cell proliferation and differentiation.

  6. Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2 (show MYL2 Proteins), was 100 times stronger than that of daunorubicin (DNR) and CM.

  7. hypertrophied myocytes after TAC have alpha-MyHC only. These data challenge the current paradigm of the fetal hypertrophic gene program and identify a new subpopulation of smaller working ventricular myocytes with more myosin.

  8. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4 (show CD4 Proteins)+ T cells in myocarditis

  9. Silencing of aMHC is associated at its promoter with decreased H3K4me3, but not decreased H3ac.

  10. TCDD represses the expression of the cardiac development-specific Nkx2.5 homeobox transcription factor, of cardiac troponin-T and of alpha- and beta-myosin heavy chains.

Zebrafish Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Data show that an atrium-specific contractility defect due to mutation of the atrial myosin heavy chain has a profound impact on ventricular development.

Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) Protein Profile

Protein Summary

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.

Gene names and symbols associated with MYH6

  • myosin heavy chain 6 (Myh6)
  • myosin heavy chain 6 (MYH6)
  • myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6)
  • myosin, heavy chain 6, cardiac muscle, alpha (MYH6)
  • myosin-6 (MYH6)
  • myosin-6 (LOC101120580)
  • myosin, heavy chain 6, cardiac muscle, alpha (myh6)
  • A830009F23Rik protein
  • AA517445 protein
  • alpha-MHC protein
  • amhc protein
  • ASD3 protein
  • CMD1EE protein
  • CMH14 protein
  • MYHC protein
  • Myhc-a protein
  • MYHCA protein
  • SSS3 protein

Protein level used designations for MYH6

myHC-alpha , myosin heavy chain 6 , myosin heavy chain polypeptide 6 cardiac muscle adult , myosin heavy chain, cardiac muscle alpha isoform , myosin heavy chain, polypeptide 6, cardiac muscle, alpha , myosin, heavy polypeptide 6, cardiac muscle, alpha , myosin-6 , myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha) , alpha cardiac MHC , alpha myosin , cardiac myosin heavy chain alpha isoform , cardiomyopathy, hypertrophic 1 , myosin heavy chain, cardiac muscle, adult , myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , atrial myosin heavy chain , myosin-7 , wea , weak atrium

GENE ID SPECIES
29556 Rattus norvegicus
4624 Homo sapiens
17888 Mus musculus
100685644 Canis lupus familiaris
100296004 Bos taurus
100125987 Oryctolagus cuniculus
100727418 Cavia porcellus
101120580 Ovis aries
386711 Danio rerio
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