Myosin Heavy Chain 6, Cardiac Muscle, alpha Proteins (MYH6)

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. Additionally we are shipping Myosin Heavy Chain 6, Cardiac Muscle, alpha Antibodies (41) and Myosin Heavy Chain 6, Cardiac Muscle, alpha Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYH6 29556  
MYH6 4624 P13533
Mouse MYH6 MYH6 17888 Q02566
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Top Myosin Heavy Chain 6, Cardiac Muscle, alpha Proteins at antibodies-online.com

Showing 5 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$752.00
Details
Yeast Human His tag 100 μg Log in to see 8 to 11 Days
$484.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$3,309.17
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
Details

MYH6 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,

More Proteins for Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) Interaction Partners

Human Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Three loci with high mutation frequencies, the 138665410 FOXL2 gene variant, the 23862952 MYH6 gene variant, and the 71098693 HYDIN gene variant were found to be significantly associated with sporadic Atrial Septal Defect (P<0.05); variants in FOXL2 and MYH6 were found in patients with isolated, sporadic Atrial Septal Defect (P<5x10-4).

  2. We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes.

  3. The etiology of MYH6-associated HLHS can be informed using iPSCs.

  4. Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6, and FLT4 as causative genes.

  5. the P830L and A1004S alphaMHC mutations alter myocyte contractility in completely different ways while at the same preserving peak intracellular calcium

  6. Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction.

  7. human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other.

  8. The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation.

  9. Data from molecular dynamic/docking simulations suggest that actin-myosin binding free energy accepts contributions from both electrostatic and nonpolar forces; studies compare cardiac alpha-myosin, beta-myosin, and fast skeletal muscle myosin.

  10. R1165C mutation in MYH9 gene is associated with macroscopic hematuria and presenile cataract.

  11. Perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial Secundum-type atrial septal defects.

  12. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4+ T cells in myocarditis

  13. the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant

  14. data indicate that functional variants of MYH6 are associated with cardiac malformations in addition to atrial septal defect and provide a novel potential mechanism

  15. The mutations in MYH6 cause when a genetic cause can be identified, which has estimated to occur in 65% of hypertrophic cardiomyopathy.

  16. Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer.

  17. results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed

  18. Mutation in myosin heavy chain 6 causes atrial septal defect

  19. Three heterozygous MYH6 missense mutations were identified in dilated cardiomyopathy probands (P830L, A1004S, and E1457K; 4.3% of probands). A Q1065H mutation was detected in 1 of 21 hypertrophic cardiomyopathy probands.

  20. the large step of dimeric myosin VI is primarily made possible by a medial tail in each monomer that forms a rare single alpha-helix of approximately 10 nm, which is anchored to the calmodulin-bound IQ domain by a globular proximal tail.

Mouse (Murine) Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. The stress-induced Brg1-G9a/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  2. Taken together, these results highlight both the importance of using alphaMyHC-Cre mice as controls in conditional knockout studies as well as the need for a less cardiotoxic Cre driver for the field.

  3. Data indicate that the cardiac myosin heavy chain alpha isoform (alphaMHC(403)) transgenic model closely recapitulates human disease.

  4. mutant sarcomeres manifest irreversible cardiomyocyte defects that induce LVH.

  5. Transfecting human beta-MHC V606M into the mouse cardiac alpha-MHC gene caused hypertrophic cardiomyopathy without left ventricular hypertrophy, disarray of myofibers, and interstitial fibrosis. Cyclosporine or Arg453Cys or Arg719Trp worsened the phenotype.

  6. Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

  7. Results indicate the downstream targets of insulin, cyclin D1, BAD, alpha-MHC, and GATA-4, elucidate a molecular mechanism of insulin in promoting cell proliferation and differentiation.

  8. Transgenic mouse alpha- and beta-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

  9. Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.

  10. hypertrophied myocytes after TAC have alpha-MyHC only. These data challenge the current paradigm of the fetal hypertrophic gene program and identify a new subpopulation of smaller working ventricular myocytes with more myosin.

  11. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4+ T cells in myocarditis

  12. Silencing of aMHC is associated at its promoter with decreased H3K4me3, but not decreased H3ac.

  13. TCDD represses the expression of the cardiac development-specific Nkx2.5 homeobox transcription factor, of cardiac troponin-T and of alpha- and beta-myosin heavy chains.

  14. These results suggest that the depressed molecular function in cardiac myosin may initiate the events that cause the heart to remodel and become pathologically dilated.

  15. the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208

  16. residues situated within or close to the actin-binding interface of the myosin head influence actin binding and thereby modulate actin-activated ATPase activity

  17. Development of hypertrophic cardiomyopathy due to alpha-myosin heavy chain mutations may be accelerated by male hormones or the absence of female hormones.

  18. functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform

Zebrafish Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Data show that an atrium-specific contractility defect due to mutation of the atrial myosin heavy chain has a profound impact on ventricular development.

Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) Protein Profile

Protein Summary

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.

Gene names and symbols associated with MYH6

  • myosin heavy chain 6 (Myh6)
  • myosin heavy chain 6 (MYH6)
  • myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6)
  • myosin, heavy chain 6, cardiac muscle, alpha (MYH6)
  • myosin-6 (MYH6)
  • myosin-6 (LOC101120580)
  • myosin, heavy chain 6, cardiac muscle, alpha (myh6)
  • A830009F23Rik protein
  • AA517445 protein
  • alpha-MHC protein
  • amhc protein
  • ASD3 protein
  • CMD1EE protein
  • CMH14 protein
  • MYHC protein
  • Myhc-a protein
  • MYHCA protein
  • SSS3 protein

Protein level used designations for MYH6

myHC-alpha , myosin heavy chain 6 , myosin heavy chain polypeptide 6 cardiac muscle adult , myosin heavy chain, cardiac muscle alpha isoform , myosin heavy chain, polypeptide 6, cardiac muscle, alpha , myosin, heavy polypeptide 6, cardiac muscle, alpha , myosin-6 , myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha) , alpha cardiac MHC , alpha myosin , cardiac myosin heavy chain alpha isoform , cardiomyopathy, hypertrophic 1 , myosin heavy chain, cardiac muscle, adult , myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , atrial myosin heavy chain , myosin-7 , wea , weak atrium

GENE ID SPECIES
29556 Rattus norvegicus
4624 Homo sapiens
17888 Mus musculus
100685644 Canis lupus familiaris
100296004 Bos taurus
100125987 Oryctolagus cuniculus
100727418 Cavia porcellus
101120580 Ovis aries
386711 Danio rerio
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