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NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. Additionally we are shipping NAT1 Antibodies (95) and NAT1 Kits (10) and many more products for this protein.
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Human NAT1 Protein expressed in Wheat germ - ABIN1311997
Millner, Doll, Cai, States, Hein: Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent. in Drug metabolism and disposition: the biological fate of chemicals 2011
Show all 2 Pubmed References
Data showed that NAT1 (show EIF4G2 Proteins), NAT2 (show SLC38A1 Proteins), and ESR1 (show ESR1 Proteins) expression were increased in primary breast tumor tissue and that NAT1 (show EIF4G2 Proteins) expression was much higher than NAT2 (show SLC38A1 Proteins). NAT1 (show EIF4G2 Proteins) and ESR1 (show ESR1 Proteins) expression were strongly associated, whereas NAT2 (show SLC38A1 Proteins) and ESR1 (show ESR1 Proteins) expression were not. Although NAT1 (show EIF4G2 Proteins) and NAT2 (show SLC38A1 Proteins) expression were associated, the magnitude was moderate.
the results suggested that there was no association between NAT1 (show EIF4G2 Proteins)*10 allele and bladder cancer risk (meta-analysis).
identified a novel endogenous role for human NAT1 (show EIF4G2 Proteins) that might explain some of its effects in cancer cell growth and survival
N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.
The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (show MTHFR Proteins) c.677C>T p.A222V(rs1801133), TP53 (show TP53 Proteins) c.215C>G p.R72P (rs1042522), NQO1 (show NQO1 Proteins) c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 Proteins) alleles imputed as fast acetylator genotypes. [meta-analysis]
NAT1 (show EIF4G2 Proteins) genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.
NAT1 (show EIF4G2 Proteins) genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.
NAT1 (show EIF4G2 Proteins) has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.
We report that miR (show MLXIP Proteins)-1290 directly targets the NAT1 (show EIF4G2 Proteins) 3'-UTR and that NAT1 (show EIF4G2 Proteins) protein expression is correlated with improved OS of breast cancer patients.
Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine
these studies demonstrate that Nat1 (show EIF4G2 Proteins) deletion promotes reduced mitochondrial activity and is associated with ectopic lipid-induced insulin (show INS Proteins) resistance. These results provide a potential genetic link among mitochondrial dysfunction with increased ectopic lipid deposition, insulin (show INS Proteins) resistance, and type 2 diabetes.
Ca(2 (show CA2 Proteins)+)-dependent N-acyltransferase absolutely required Calcium for its activity and the activity was enhanced by phosphatidylserine.
Nat1 (show EIF4G2 Proteins) is involved in the translation of proteins that are required for cell differentiation.
This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.
our results suggest that Nat1 (show EIF4G2 Proteins) deficiency results in mitochondrial dysfunction, which may constitute a mechanistic link between this gene and insulin (show INS Proteins) resistance .
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 (show NAT2 Proteins) defined by substrate specificity and inhibitor binding.(
In adipocytes, Nat1 (show EIF4G2 Proteins) silencing lowered insulin (show INS Proteins)-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1 (show EIF4G2 Proteins)(-) mice had high fasting blood glucose, insulin (show INS Proteins), and triglycerides and low insulin (show INS Proteins) sensitivity.
Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT (show BRD2 Proteins) gene expression is species dependent
NAT1 (show EIF4G2 Proteins) affects cell growth and morphology
Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
N-acetyltransferase type 1
, arylamide acetylase 1
, arylamine N-acetyltransferase 1
, monomorphic arylamine N-acetyltransferase
, N(alpha)-acetyltransferase 15, NatA auxiliary subunit
, N-acetyl transferase 1, liver, blood
, N-acetyltransferase (arylamine N-acetyltransferase)
, N-acetyltransferase 1 (arylamine N-acetyltransferase)
, Arylamide acetylase 1
, Monomorphic arylamine N-acetyltransferase
, NAT1 9
, acetyltransferase AT-I
, arylamine acetyltransferase