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N4BP2 encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. Additionally we are shipping N4BP2 Kits (4) and and many more products for this protein.
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We found that a burden of low-frequency coding variants in N4BP2, CDSN (show CDSN Antibodies), PRTG (show PRTG Antibodies), and AHRR (show CYP1A1 Antibodies) were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL (show NHLH1 Antibodies)/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL (show NHLH1 Antibodies)/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL (show NHLH1 Antibodies)/P
the N-terminal extended region of the Smr domain in the native B3bp may function as a regulatory region for the nicking endonuclease
B3BP is a 5'-polynucleotide kinase
These data suggest that haplotype blocks ATTA and GTTG of N4BP2 is correlation with the risk of sporadic nasopharyngeal carcinoma in the Southern Chinese population.
The solution structure of the functionally active Smr domain of the Bcl3-binding protein (also known as Nedd4-binding protein 2), a protein with unknown function that lacks other domains present in MutS proteins, is determined.
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination.
, NEDD4-binding protein 2
, Bcl3 binding protein
, Nedd4 binding protein 2