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The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal NRAP Primary Antibody for ICC, IF - ABIN4340645
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Loss-of-function mutation in NRAP gene is associated with dilated cardiomyopathy.
Highly conserved and exclusively expressed in cardiac and skeletal muscle. Candidate cause for cardiac and skeletal myopathies
Nrarp-deficient embryos and mice exhibit genetic background-dependent defects of the axial skeleton. In Nrarp mutant embryos, the posterior somite compartment was expanded.
Results show that chronic NRAP overexpression in the mouse leads to right ventricular cardiomyopathy by 10 months of age.
May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.