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ONECUT1 encodes a member of the Cut homeobox family of transcription factors. Additionally we are shipping One Cut Homeobox 1 Antibodies (55) and One Cut Homeobox 1 Kits (22) and many more products for this protein.
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These results suggest that Oc1 and Pdx1 (show PDX1 Proteins) cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells.
Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1 (show ISL1 Proteins)/Lhx3 (show LHX3 Proteins) in nascent motor neurons and Isl1 (show ISL1 Proteins)/Onecut1 in maturing hypaxial motor neurons.
Data show that growth hormone (GH (show GH1 Proteins))/lipopolysaccharides (LPS (show TLR4 Proteins)) co-treatment enhanced hepatocyte nuclear factor 6 (Hnf6) expression with corresponding attenuation of apoptosis in WT-derived hepatocytes, but not in KO hepatocytes.
HNF6 binding was sex independent at a majority of binding sites, and HNF6 peaks were frequently associated with cobinding by multiple other liver transcription factors, consistent with HNF6 playing a global regulatory role in both male and female liver.
with Lmx1a (show LMX1A Proteins) to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1 (show WNT1 Proteins)-Lmx1a (show LMX1A Proteins) pathway.
Onecut1 and Onecut2 have roles in operating downstream of Pax6 (show PAX6 Proteins) to regulate horizontal cell development
similar to Onecut1, Onecut2 is also necessary for the formation of normal numbers of horizontal cells in the developing retina.
identified downstream genes of Oc1 and Oc2 that shows that the onecut factors suppress the production of the late cell type, rods, indicating that the two factors contribute to the competence of retinal progenitor cells for early retinal cell fates
Sex-dependent growth hormone (show GH1 Proteins) secretion patterns affect the expression of HNF6 in liver.
Liver cell plasticity is competent for regeneration of intrahepatic bile duct independent of Notch (show NOTCH1 Proteins) signaling via Rbpj (show RBPJ Proteins) and Hnf6.
Reduced HNF6 expression is associated with metastasis of cholangiocarcinoma.
HNF6 is a novel host factor that can restrict hepatitis B virus replication via both transcriptional and posttranscriptional mechanisms.
The negative correlation between HNF6 expression and pancreatic cancer progression suggests that HNF6 maintains pancreatic epithelial homeostasis, and that its loss contributes to the progression from intraepithelial neoplasms to ductal adenocarcinoma.
HNF6 plays an important role in the gene regulation of CYP3A4 (show CYP3A4 Proteins) during development from the fetal period to the postnatal period.
HNF6 inhibits EMT (show ITK Proteins), cell migration, and invasive growth through a mechanism involving the transcriptional activation of p53 (show TP53 Proteins).
Mutations at the -5/-6 site of the F9 promotor account for the majority of hemophilia B Leyden cases and disrupt the binding of ONECUT1 and ONECUT2.
HNF6 and Sox9 (show SOX9 Proteins) are new biomarkers of pancreatic acinar-to-ductal metaplasia and constitute candidate targets for preventive treatment in cases when acinar-to-ductal metaplasia may lead to cancer.
Hepatocyte nuclear factor 6 is one of the liver-enriched transcription factors, it utilizes the bipartite onecut-homeodomain sequence to localize to the nuclear compartment and bind specific DNA sequences of numerous target gene promoters
functional knockdown of FOXA2 (show FOXA2 Proteins) recovered HNF6 activity and inhibited growth of tumor-cells and may possibly represent a novel therapeutic target in primary and secondary liver malignancies
HNF6 has a role as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2 (show FOXA2 Proteins)
findings identify vps33b (show VPS33B Proteins) is a novel downstream target gene of the hnf6/vhnf1 (show HNF1B Proteins) pathway that regulates bile duct development in zebrafish
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.
HNF-3/forkhead homolog 12
, hepatic nuclear factor 6
, hepatocyte nuclear factor 6
, one cut homeobox 1
, one cut domain family member 1
, one cut domain, family member 1
, hepatocyte nuclear factor 6, alpha
, hepatocyte nuclear factor 6 alpha
, one cut domain, family member 1, like