Oxysterol Binding Protein-Like 1A Proteins (OSBPL1A)

OSBPL1A encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Additionally we are shipping Oxysterol Binding Protein-Like 1A Antibodies (69) and and many more products for this protein.

list all proteins	Gene Name	GeneID	UniProt
	OSBPL1A	114876	Q9BXW6
	OSBPL1A	64291	Q91XL9
Rat OSBPL1A	OSBPL1A	259221	Q8K4M9

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Top Oxysterol Binding Protein-Like 1A Proteins at antibodies-online.com

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Catalog No.	Origin	Source	Conjugate	Quantity	Supplier	Delivery	Price	Details
ABIN3094367	Insect Cells	Human	His tag	1 mg	Log in to see	70 Days	$13,984.89	Details
ABIN3136815	Insect Cells	Mouse	His tag	1 mg	Log in to see	70 Days	$13,984.89	Details
ABIN1313682	Wheat germ	Human	GST tag	10 μg	Log in to see	11 to 12 Days	$414.29	Details
ABIN2727984	HEK-293 Cells	Human	Myc-DYKDDDDK Tag	20 μg	Log in to see	Available	$547.80	Details

OSBPL1A Proteins by Origin and Source

Origin	Expressed in	Conjugate
Human	, ,	, ,
Mouse (Murine)

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More Proteins for Oxysterol Binding Protein-Like 1A (OSBPL1A) Interaction Partners

Human Oxysterol Binding Protein-Like 1A (OSBPL1A) interaction partners

This study validated that rs3746444 polymorphism influenced the expression of miR499a, its target gene, osbpl1a, and thereby associated with the HDL (show HSD11B1 Proteins) level, which makes it a potential factor involved in the mechanism of atherosclerosis.
a familial loss-of-function mutation in OSBPL1A affects the first step of the reverse cholesterol transport process and associates with a low HDL (show HSD11B1 Proteins)-C phenotype
ORP1L-VAP (show F10 Proteins) complexes also support transport of LDL-derived cholesterol from endosomes to the endoplasmic reticulum when ORP1L was bound to human adenovirus RIDalpha. RIDalpha-induced lipid trafficking also attenuated proinflammatory signaling by Toll-like receptor 4 (show TLR4 Proteins), which has a central role in adenovirus pathogenesis and is known to be tightly regulated by cholesterol-rich "lipid rafts."
ORP1S is a cytoplasmic sterol sensor, which transports sterols to the nucleus and promotes LXR (show NR1H3 Proteins) regulated trans-activation of apoE (show APOE Proteins).
The study shows that OSBPL1A binds several oxysterols and cholesterol, and characterize a mutant, OSBPL1A Delta560-563, defective in oxysterol bi (show APOA1 Proteins)nding.
Results suggest that the two forms of oxysterol binding protein-related protein-1 (ORP1) are functionally distinct and that ORP1L is involved in control of cellular lipid metabolism
binds to Rab7 (show RAB7B Proteins), modifies its functional cycle, and can interfere with lysosome organization and endocytic membrane trafficking.
OSBPL1A was preferentially expressed from the maternal allele
Results describe how ORP1L contacts VAP (show F10 Proteins) to control Rab7 (show RAB7B Proteins)-RILP (show RILP Proteins)-p150 Glued (show DCTN1 Proteins) and late endosome positioning.

Mouse (Murine) Oxysterol Binding Protein-Like 1A (OSBPL1A) interaction partners

Osbpl1a silencing in macrophage foam cells enhances endosome motility and results in inhibition of [(3)H]cholesterol efflux to apolipoprotein A-I (show APOA1 Proteins).
OSBP (show OSBP Proteins) regulates hepatic TG metabolism and suggest the involvement of OSBP (show OSBP Proteins) in the insulin (show INS Proteins) signaling pathways that control hepatic lipogenesis.

Oxysterol Binding Protein-Like 1A (OSBPL1A) Protein Profile

Protein Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist\; they encode different isoforms.

Gene names and symbols associated with OSBPL1A

oxysterol binding protein like 1A (OSBPL1A)
oxysterol binding protein-like 1A (Osbpl1a)
oxysterol binding protein-like 1A (osbpl1a)
oxysterol binding protein-like 1A (OSBPL1A)
oxysterol-binding protein-related protein 1 (Tsp_09273)
oxysterol-binding protein-related protein 1 (Tsp_03387)
oxysterol binding protein like 1A L homeolog (osbpl1a.L)
oxysterol binding protein like 1A (osbpl1a)
oxysterol binding protein like 1A (Osbpl1a)

DKFZp459N1538 protein
G430090F17Rik protein
Gm753 protein
ORP-1 protein
ORP1 protein
Osbpl1b protein
si:dkey-121a11.8 protein

Protein level used designations for OSBPL1A

OSBP-related protein 1 , oxysterol binding protein-like 1B , oxysterol-binding protein-related protein 1 , oxysterol-binding protein-related protein 1 variant 1 , oxysterol-binding protein-related protein 1 variant 2 , ORP-1 , oxysterol-binding protein-like 1A , oxysterol binding protein-like 1A , oxysterol binding protein-like protein 1A , oxysterol-binding protein-related protein 1-like

GENE ID	SPECIES
114876	Homo sapiens
64291	Mus musculus
259221	Rattus norvegicus
565503	Danio rerio
100174299	Pongo abelii
10905070	Trichinella spiralis
10909128	Trichinella spiralis
421079	Gallus gallus
468500	Pan troglodytes
480761	Canis lupus familiaris
495678	Xenopus laevis
616555	Bos taurus
677867	Macaca mulatta
100010444	Monodelphis domestica
100127588	Xenopus (Silurana) tropicalis
100356707	Oryctolagus cuniculus
100403124	Callithrix jacchus
100480218	Ailuropoda melanoleuca
100511459	Sus scrofa
100540838	Meleagris gallopavo
100557357	Anolis carolinensis
100600026	Nomascus leucogenys
100717854	Cavia porcellus

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