Oxysterol Binding Protein-Like 8 (OSBPL8) ELISA Kits

OSBPL8 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Additionally we are shipping Oxysterol Binding Protein-Like 8 Antibodies (17) and Oxysterol Binding Protein-Like 8 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat OSBPL8 OSBPL8 314824  
OSBPL8 114882 Q9BZF1
Anti-Mouse OSBPL8 OSBPL8 237542  
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Top Oxysterol Binding Protein-Like 8 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.138 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days

More ELISA Kits for Oxysterol Binding Protein-Like 8 Interaction Partners

Human Oxysterol Binding Protein-Like 8 (OSBPL8) interaction partners

  1. ORP5/8 recruitment to the plasma membrane occurs through interactions with the N-terminal Pleckstrin homology domains and adjacent basic residues of ORP5/8 with both phosphatidylinositol 4-phosphate and Phosphatidylinositol 4,5-bisphosphate.

  2. ORP5/8 regulate Ca(2+) signaling at specific membrane contact sites foci.

  3. Examination of a series of deletion constructs demonstrated that both the N-terminal polybasic region and the PH domain are required for proper targeting of the short splice variant ORP8S to the PM-ER contact site in Chinese hamster ovary cells.

  4. ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.

  5. we found that overexpression of ORP8 significantly inhibits GC cell proliferation and implanted tumor growth in vivo. Induction of ER stress, inhibition of Wnt signaling, and apoptotic cell death are involved in ORP8-induced inhibition of GC cell proliferation.

  6. mammalian ORP5 and ORP8 proteins localize to ER-mitochondrial MCS, in addition to ER-PM contact sites.

  7. the present study suggests that ORP8 may mediate the cytotoxicity of 25-hydroxycholesterol.

  8. ORP5 and ORP8 could mediate PI4P/phosphatidylserine (PS) countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM), thus delivering PI4P to the ER-localized PI4P phosphatase Sac1 for degradation and PS from the ER to the PM.

  9. role of ORP8 in Fas translocation to the plasma membrane and its down-regulation by miR-143 offer a putative mechanistic explanation for HCC resistance to apoptosis

  10. Data indicate that miR-143 impairs insulin action via downregulation of oxysterol-binding protein-related protein 8 (ORP8).

  11. ORP8 overexpression resulted in reduced expression of the aP2 mRNA, while down-regulation of adiponectin and aP2 was observed in ORP11 silenced cells. ORP8 overexpression or silencing of ORP11 markedly decreased cellular triglyceride storage.

  12. results reveal that ORP8 has the capacity to modulate lipid homeostasis and SREBP activity, probably through an indirect mechanism, and provide clues of an entirely new mode of ORP action

  13. Data identify ORP8 as a negative regulator of ABCA1 expression and macrophage cholesterol efflux. ORP8 may, thus, modulate the development of atherosclerosis.

  14. occurrence of an unusual TG 3' splice site in intron 2

Mouse (Murine) Oxysterol Binding Protein-Like 8 (OSBPL8) interaction partners

  1. Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice.

  2. Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.

  3. aspects of ORP8 function in macrophages not directly involving lipid metabolism, but rather associated with nuclear functions, microtubule organization, and migration capacity

Oxysterol Binding Protein-Like 8 (OSBPL8) Antigen Profile

Antigen Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with OSBPL8

  • oxysterol binding protein-like 8 (Osbpl8) antibody
  • oxysterol binding protein like 8 (OSBPL8) antibody
  • oxysterol binding protein like 8 L homeolog (osbpl8.L) antibody
  • oxysterol binding protein like 8 (osbpl8) antibody
  • oxysterol-binding protein-related protein 8 (LOC100175952) antibody
  • AA536976 antibody
  • AA536995 antibody
  • C730029P18Rik antibody
  • D330025H14Rik antibody
  • DKFZp469P0923 antibody
  • MST120 antibody
  • MSTP120 antibody
  • ORP-8 antibody
  • ORP8 antibody
  • OSBP10 antibody
  • RGD1561474 antibody

Protein level used designations for OSBPL8

oxysterol-binding protein-related protein 8 , oxysterol binding protein-like 8 , oxysterol-binding protein-like protein 8 , oxysterol-binding protein-related protein 8-like , ORP-8 , OSBP-related protein 8

314824 Rattus norvegicus
417866 Gallus gallus
446929 Xenopus laevis
452085 Pan troglodytes
693338 Macaca mulatta
100018363 Monodelphis domestica
100059086 Equus caballus
100145444 Xenopus (Silurana) tropicalis
100172591 Pongo abelii
100175952 Ciona intestinalis
100218984 Taeniopygia guttata
100356792 Oryctolagus cuniculus
100484438 Ailuropoda melanoleuca
100525288 Sus scrofa
100566303 Anolis carolinensis
100595122 Nomascus leucogenys
100409878 Callithrix jacchus
114882 Homo sapiens
475408 Canis lupus familiaris
533350 Bos taurus
237542 Mus musculus
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