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Functions in cytoplasmic mRNA decay. Additionally we are shipping PAN3 Proteins (4) and many more products for this protein.
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These results reveal a new fundamental step governing mammalian mRNA metabolism. We propose that the first phase of deadenylation, coordinated through the interplay among the two Pan3 isoforms, Pan2, and PABP, represents a cytoplasmic mRNA maturation step important for proper mRNA turnover.
arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA
hPan2 and hPan3 have roles in mRNA decay and exhibit cytoplasmic co-localization
Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity.
PABP1-dependent poly A-specific ribonuclease subunit PAN3
, PAN3 polyA specific ribonuclease subunit homolog
, PAB-dependent poly(A)-specific ribonuclease subunit 3
, PABP-dependent poly(A) nuclease 3
, Pabp-dependent poly(A) nuclease 3
, Pabp1-dependent poly A-specific ribonuclease subunit Pan3