PDZ Domain Containing 3 Proteins (PDZD3)

Guanylyl cyclase C (GCC, or GUCY2C\; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR\; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002

• PDZ domain containing 3 (Pdzd3)
• PDZ domain containing 3b (pdzd3b)
• PDZ domain containing 3 (PDZD3)

• IKEPP protein
• NaPi-Cap2 protein
• NHERF4 protein
• Pdzk2 protein
• RGD1559807 protein
• Show all synonym aliases
• zgc:194812 protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF4 , PDZ domain containing 3 , NHERF-4 , PDZ domain containing 2 , PDZ domain-containing protein 2 , PDZ domain-containing protein 3 , intestinal and kidney enriched PDZ protein , intestinal and kidney-enriched PDZ protein , na/Pi cotransporter C-terminal-associated protein 2 , naPi-Cap2 , natrium-phosphate cotransporter IIa C-terminal-associated protein 2 , sodium-hydrogen exchanger regulatory factor 4 , sodium-phosphate cotransporter IIa C-terminal-associated protein 2