POU Class 2 Associating Factor 1 Proteins (POU2AF1)

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. Additionally we are shipping POU2AF1 Antibodies (146) and POU2AF1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POU2AF1 5450 Q16633
Rat POU2AF1 POU2AF1 690528  
POU2AF1 18985 Q64693
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Top POU2AF1 Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days

POU2AF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for POU Class 2 Associating Factor 1 (POU2AF1) Interaction Partners

Human POU Class 2 Associating Factor 1 (POU2AF1) interaction partners

  1. These findings demonstrate for the first time that functional polymorphism in the 3'-UTR of POU2AF1 is associated with susceptibility, and that single-nucleotide polymorphisms interaction with hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-633 affects gene expression and increases the risk of lymphoma.

  2. Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan-B cell markers

  3. these findings suggest a novel function of POU2AF1 as a potential regulator of host defense genes in the human airway epithelium.

  4. It has been identified as a new disease susceptibility gene among Japanese. Though different from Europeans, it is indicated that a B lymphocyte differentiation route shares a common disease developing process. [Review]

  5. Two significant susceptibility loci, TNFSF15 (show TNFSF15 Proteins) (rs4979462) and POU2AF1 (rs4938534) (combined odds ratio [OR] = 1.56, p = 2.84 x 10(-14) for rs4979462.

  6. Data show that Igh 3' enhancer-bound OCA-B and promoter-bound TFII-I mediate promoter-enhancer interactions, in both cis and trans, that are important for Igh transcription.

  7. Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5 (show PAX5 Proteins), Oct-2, BOB.1, Bcl-6 (show BCL6 Proteins) protein and MUM1/IRF-4 (show IRF4 Proteins).

  8. On multivariate analysis, co-expression of OCT-2/BOB.1 remained predictive for achievement of complete remission and increased risk of relapse.

  9. The expression of the octamer cofactor gene OBF-1 (Bob1/OCA-B) is sufficient to override the silencing effects of the B29 (show CD79B Proteins) silencer, indicating that OBF-1 plays a critical role in B cell-specific B29 (show CD79B Proteins) promoter expression.

  10. enhances transcriptional potential of Oct1 (show POU2F1 Proteins)

Mouse (Murine) POU Class 2 Associating Factor 1 (POU2AF1) interaction partners

  1. Bob1 promotes the development of follicular T helper cells via Bcl6 (show BCL6 Proteins).Bob1 is directly involved in follicular T helper cell differentiation and required for mounting normal T cell-dependent B-cell responses.

  2. Findings indicate octamer transcription factor-1 (show HNF1A Proteins) (Oct1 (show POU2F1 Proteins)) and Oct binding factor 1 protein (OCA-B) as central mediators of CD4 (show CD4 Proteins)(+) T cell memory.

  3. overexpression of DDX60 did not potentiate IFN induction

  4. Loss of Obf1 is associated with IgM-mediated glomerulonephritis.

  5. The transcription factor Bob1 counteracts B cell activation (show BLNK Proteins) and regulates miR (show MLXIP Proteins)-146a in B cells.

  6. Expressing a stable Bob1 mutant in B cells suppresses cell proliferation and induces changes in surface marker expression commonly seen during B-cell differentiation.

  7. Data show that IL-6 (show IL6 Proteins) and IL-21 (show IL21 Proteins) act with different kinetics during the germinal centers (GCs (show UGCG Proteins)) response and that B cells, in an Oct2 (show SLC22A2 Proteins)/OBF-1-dependent manner, can supply the IL-6 (show IL6 Proteins) for early induction of T follicular helper cells (T(FH) development.

  8. OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.

  9. Data show that the expression of BOB.1/OBF (show IZUMO1 Proteins).1 in peripheral B cells is required for the development of marginal zone B lymphocytes.

  10. Transcriptional coactivator OBF-1 is essential for germinal center formation in Aiolos (show IKZF3 Proteins)-deficient mice; lack of OBF-1 reverses several Aiolos (show IKZF3 Proteins) mutant mouse phenotypes.

POU2AF1 Protein Profile

Protein Summary

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Gene names and symbols associated with POU2AF1

  • POU class 2 associating factor 1 (POU2AF1)
  • POU class 2 associating factor 1 (Pou2af1)
  • POU domain, class 2, associating factor 1 (Pou2af1)
  • Bob-1 protein
  • BOB.1 protein
  • Bob1 protein
  • OBF-1 protein
  • OBF.1 protein
  • OBF1 protein
  • OCA-B protein
  • OCAB protein

Protein level used designations for POU2AF1

B-cell-specific coactivator OBF-1 , BOB-1 , OCA-B , OCT-binding factor 1 , POU domain class 2-associating factor 1 , POU domain, class 2, associating factor 1 , OCT binding factor 1

5450 Homo sapiens
528475 Bos taurus
690528 Rattus norvegicus
18985 Mus musculus
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