POU Domain, Class 2, Transcription Factor 1 Proteins (POU2F1)

The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Additionally we are shipping POU2F1 Antibodies (152) and POU2F1 Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POU2F1 5451 P14859
POU2F1 171068 P31503
POU2F1 18986 P25425
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Top POU2F1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$704.00
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Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$720.00
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Yeast Macropus eugenii His tag   1 mg Log in to see 60 to 71 Days
$2,097.33
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,828.00
Details

POU2F1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

Top referenced POU2F1 Proteins

  1. Human POU2F1 Protein expressed in Wheat germ - ABIN1315780 : Holt, Zhang, Binia, Dixon, Vandiedonck, Cookson, Knight, Moffatt: Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1). in The Journal of allergy and clinical immunology 2011 (PubMed)

More Proteins for POU Domain, Class 2, Transcription Factor 1 (POU2F1) Interaction Partners

Human POU Domain, Class 2, Transcription Factor 1 (POU2F1) interaction partners

  1. Results identify BRCA1 as an Oct1 ubiquitin ligase that catalyzes Oct1 degradation to promote oxidative metabolism and restrict tumorigenicity.

  2. Changes in the expression level of Oct-1A, Oct-1L, Oct-1X, and Oct-1Z isoforms and CD14 surface antigen during differentiation of HL-60 monocytic cells induced in vitro by dimethyl sulfoxide were studied, and the expression level of the four Oct-1 isoforms in vivo in human monocytes was determined.

  3. E6/E7-p53-POU2F1-CTHRC1 axis promotes cervical cancer cell invasion and metastasis

  4. our results indicate that POU2F1 over-expression is positively associated with aggressive phenotypes and poor survival in patients with HCC, and POU2F1 regulated by AKT pathway promotes HCC aggressive phenotypes by regulating the transcription of EMT genes.

  5. A significant influence of OCT1 mRNA expression on the clinical outcome of the disease was observed.

  6. Children with certain OCT1 genotypes have higher risk for respiratory depression and nausea and vomiting, postoperatively, following morphine administration.

  7. High POU2F1 expression is associated with liver cancer.

  8. THE results of this investigation demonstrate that genetic polymorphisms in the hepatic uptake transporter OCT1 affect the pharmacokinetics and efficacy of tramadol.

  9. Hepatic distribution of metformin was significantly reduced after oral administration in individuals with genetic polymorphisms in OCT1.

  10. We found that a combination of two polymorphisms in hOCT1 that seem to play the role of predictor for imatinib in both efficacy and toxicity

  11. hOCT1 mRNA expression may serve as a clinical biomarker of response to imatinib and could be useful to predict Imatinib mesylate therapy outcome of chronic myeloid leukemia patients

  12. ABCB1 and OCT1 mRNA expressions may present biological relevance to identify responder and non-responder patients to imatinib treatment

  13. Our study demonstrates that the existence of Oct-1 isoforms which vary in length and sequence at the N-terminus of the protein, also contributes in surprising diversity of Oct-1 functions in transcription regulation.

  14. HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region

  15. OCT1 transported sumatriptan with high capacity and sumatriptan uptake into human hepatocytes was strongly inhibited by the OCT1 inhibitor MPP(+)

  16. Neither AUC0-150min, ktr, CL, nor VD were associated with genetic variants in OCT1, ABCB1, and UGT2B7 (all P>0.05).

  17. Oct-1 modifies S100A4 exchange between intra- and extracellular compartments in Namalwa cells and increases their sensitivity to glucocorticoids.

  18. Low expression of POU2F1 is associated with osteosarcoma.

  19. Data indicate that octamer transcription factor 1 (OCT1; pou2f1) expression levels are significantly upregulated in colorectal cancer.

  20. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion.

Mouse (Murine) POU Domain, Class 2, Transcription Factor 1 (POU2F1) interaction partners

  1. CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGgamma.

  2. In embryonic stem cells, Oct1 co-occupies a specific set of targets with Oct4, but does not occupy differentially expressed developmental targets. Instead, Oct1 occupies these targets as cells differentiate and Oct4 declines.

  3. At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.

  4. Study conclude that pentamidine interacts with multiple transporters, is taken into brain endothelial cells by OCT1 transporter and is extruded into the blood by ATP-dependent mechanisms. These interactions along with the predominant presence of OCT1 in the luminal membrane of the BBB contribute to the limited entry of pentamidine into the brain.

  5. These results suggest that Oct-1 and GATA-3/Oct-2 direct Th2 cytokine gene expression in a cooperative manner.

  6. Findings indicate octamer transcription factor-1 (Oct1) and Oct binding factor 1 protein (OCA-B) as central mediators of CD4(+) T cell memory.

  7. levels of microRNA-451 (miR-451) are negatively regulated through the phosphorylation and inactivation of its direct transcriptional activator OCT1 by 5' AMP-activated protein kinase

  8. Oct1 mRNA expression was decreased in mice with both ob/ob and methionine/choline deficiency models of nonalcoholic steatohepatitis.

  9. OCT1 is a driver of synbindin-mediated ERK signalling and a promising marker for the prognosis and molecular subtyping of gastric cancer.

  10. studies implicate OCT1 as well as metformin in thiamine disposition, suggesting an intriguing and parallel mechanism for metformin and its major hepatic transporter in metabolic function.

  11. Th17 lineage differentiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTCF.

  12. inhibition of the DNA binding activity of transcriptional repressor OCT-1 is a mechanism by which ethanol up-regulates Slc711 expression.

  13. mammary cells express beta-casein in response to prolactin in a pathway that involves gap junction intracellular communication and OCT-1 and is independent of STAT5 nuclear translocation

  14. Oct1 plays an important role not only in the pharmacokinetics of cis-diammine(pyridine)chloroplatinum(II)(CDPCP), but also in its toxicities.

  15. role for Oct1 in mitosis

  16. Oct-1 serves as a sensor for both metabolic as well as stress/survival signals.

  17. Oct1 appears to be a critical mediator of the growth arrest induced by mTOR inhibition via the control of p27(Kip1) expression.

  18. Oct1 is a switchable stabilizer of repressed and inducible states of transcription

  19. Oct1 is required in th embryo proper from late gastrulation stages onwards.

  20. OCT1 and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP and MPTP-induced dopaminergic toxicity in rodents.

Xenopus laevis POU Domain, Class 2, Transcription Factor 1 (POU2F1) interaction partners

  1. identified Oct-1 (POU2f1), a POU transcription factor, as a downstream target of Notch signaling by microarray based screen

Cow (Bovine) POU Domain, Class 2, Transcription Factor 1 (POU2F1) interaction partners

  1. The results from this study clearly demonstrate the involvement of octamer transcription factor-1 in the regulation of tracheal antimicrobial peptide and lingual antimicrobial peptide expression.

POU2F1 Protein Profile

Protein Summary

The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993

Gene names and symbols associated with POU2F1

  • POU class 2 homeobox 1 (POU2F1)
  • POU class 2 homeobox 1 (Pou2f1)
  • POU domain, class 2, transcription factor 1 (Pou2f1)
  • POU class 2 homeobox 1 S homeolog (pou2f1.S)
  • POU class 2 homeobox 1b (pou2f1b)
  • 2810482H01Rik protein
  • chOCT-1 protein
  • fc07d06 protein
  • NF-A1 protein
  • oct-1 protein
  • oct-1B protein
  • oct1 protein
  • Otf-1 protein
  • Otf1 protein
  • POU2F1 protein
  • pou2f1r protein
  • wu:fc07d06 protein
  • zgc:158360 protein

Protein level used designations for POU2F1

NF-A1 , OTF-1 , Octamer-binding transcription factor-1 , POU domain, class 2, transcription factor 1 , oct-1 , octamer-binding protein 1 , octamer-binding transcription factor 1 , POU class 2 homeobox 1 , ubiquitous transcription factor , octamer-binding protein (Oct-1) , octamer binding protein 1 , XOct1 , maternal transcription factor , xloct1-32

GENE ID SPECIES
5451 Homo sapiens
171068 Rattus norvegicus
457486 Pan troglodytes
490360 Canis lupus familiaris
18986 Mus musculus
396463 Gallus gallus
397501 Sus scrofa
399316 Xenopus laevis
100735919 Cavia porcellus
512840 Bos taurus
323702 Danio rerio
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