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The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Additionally we are shipping POU2F1 Antibodies (150) and POU2F1 Kits (26) and many more products for this protein.
Showing 8 out of 8 products:
Human POU2F1 Protein expressed in Wheat germ - ABIN1315780
Holt, Zhang, Binia, Dixon, Vandiedonck, Cookson, Knight, Moffatt: Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1). in The Journal of allergy and clinical immunology 2011
our results indicate that POU2F1 over-expression is positively associated with aggressive phenotypes and poor survival in patients with HCC (show FAM126A Proteins), and POU2F1 regulated by AKT (show AKT1 Proteins) pathway promotes HCC (show FAM126A Proteins) aggressive phenotypes by regulating the transcription of EMT (show ITK Proteins) genes.
A significant influence of OCT1 mRNA expression on the clinical outcome of the disease was observed.
Children with certain OCT1 genotypes have higher risk for respiratory depression and nausea and vomiting, postoperatively, following morphine administration.
High POU2F1 expression is associated with liver cancer.
THE results of this investigation demonstrate that genetic polymorphisms in the hepatic uptake transporter OCT1 affect the pharmacokinetics and efficacy of tramadol.
Hepatic distribution of metformin was significantly reduced after oral administration in individuals with genetic polymorphisms in OCT1.
hOCT1 mRNA expression may serve as a clinical biomarker of response to imatinib and could be useful to predict Imatinib mesylate therapy outcome of chronic myeloid leukemia (show BCL11A Proteins) patients
ABCB1 (show ABCB1 Proteins) and OCT1 mRNA expressions may present biological relevance to identify responder and non-responder patients to imatinib treatment
Our study demonstrates that the existence of Oct-1 isoforms which vary in length and sequence at the N-terminus of the protein, also contributes in surprising diversity of Oct-1 functions in transcription regulation.
HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region
In embryonic stem cells, Oct1 co-occupies a specific set of targets with Oct4 (show POU5F1 Proteins), but does not occupy differentially expressed developmental targets. Instead, Oct1 occupies these targets as cells differentiate and Oct4 (show POU5F1 Proteins) declines.
At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.
Study conclude that pentamidine interacts with multiple transporters, is taken into brain endothelial cells by OCT1 transporter and is extruded into the blood by ATP-dependent mechanisms. These interactions along with the predominant presence of OCT1 in the luminal membrane of the BBB contribute to the limited entry of pentamidine into the brain.
These results suggest that Oct-1 and GATA-3 (show GATA3 Proteins)/Oct-2 direct Th2 cytokine gene expression in a cooperative manner.
Findings indicate octamer transcription factor-1 (show HNF1A Proteins) (Oct1) and Oct binding factor 1 (show POU2AF1 Proteins) protein (OCA-B (show POU2AF1 Proteins)) as central mediators of CD4 (show CD4 Proteins)(+) T cell memory.
levels of microRNA-451 (miR (show MLXIP Proteins)-451) are negatively regulated through the phosphorylation and inactivation of its direct transcriptional activator OCT1 by 5' AMP-activated protein kinase (show PRKAA2 Proteins)
Oct1 mRNA expression was decreased in mice with both ob/ob and methionine/choline deficiency models of nonalcoholic steatohepatitis.
OCT1 is a driver of synbindin (show TRAPPC4 Proteins)-mediated ERK (show EPHB2 Proteins) signalling and a promising marker for the prognosis and molecular subtyping of gastric cancer.
studies implicate OCT1 as well as metformin in thiamine disposition, suggesting an intriguing and parallel mechanism for metformin and its major hepatic transporter in metabolic function.
Th17 lineage differentiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTCF (show CTCF Proteins).
identified Oct-1 (POU2f1), a POU transcription factor (show POU2F3 Proteins), as a downstream target of Notch (show NOTCH1 Proteins) signaling by microarray based screen
The results from this study clearly demonstrate the involvement of octamer transcription factor-1 in the regulation of tracheal antimicrobial peptide and lingual antimicrobial peptide expression.
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993
, Octamer-binding transcription factor-1
, POU domain, class 2, transcription factor 1
, octamer-binding protein 1
, octamer-binding transcription factor 1
, POU class 2 homeobox 1
, ubiquitous transcription factor
, octamer-binding protein (Oct-1)
, octamer binding protein 1
, maternal transcription factor