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The protein encoded by PRDM5 is a transcription factor of the PR-domain protein family. Additionally we are shipping PRDM5 Proteins (3) and many more products for this protein.
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Inhibiting PRDM5 expression by siRNA attenuated the IFN-gamma (show IFNG Antibodies)-triggered accumulation of active caspase-3 (show CASP3 Antibodies) and cleaved PARP (show COL11A2 Antibodies) in intestinal epithelial cells. Moreover, flow cytometry assay and CCK-8 (show CCK Antibodies) analysis revealed that PRDM5 knockdown significantly alleviated the IFN-gamma-induced (show SAMHD1 Antibodies) cellular apoptosis in HT29 cells.
Both Prdm 4 (show PRDM4 Antibodies) and Prdm 5 are expressed in human corneal endothelium, primary hCECs and in HCECs-12 cells, characterised by expression of the Na(+)/K(+)-ATPase (show ATP1A1 Antibodies).
The miR (show MLXIP Antibodies)-182 promoter is rarely methylated in epithelial ovarian cancers (EOCs), and its methylation status is associated with lower miR (show MLXIP Antibodies)-182 expression. Deletion of the PRDM5 locus may play a supportive role in miR (show MLXIP Antibodies)-182 overexpression in EOC. miR (show MLXIP Antibodies)-182 is an unfavorable prognostic factor in EOC.
The current study revealed a novel mutation in the PRDM5 gene in a Brittle cornea syndrome (BCS (show BCS1L Antibodies)) family and recurrent mutation in a sporadic BCS (show BCS1L Antibodies) patient.
Genetic variants in PRDM5 can lead to various syndromic and nonsyndromic disorders affecting the anterior segment of the eye.
Defective interaction of PRDM5 with repressive complexes, and dysregulation of H3K9me2, play a role in PRDM5-associated disease.
Reduced expression of PRDM5 was observed in the cornea and retina of brittle cornea syndrome patients.
These data suggest that PRDM5 is a relevant tumour suppressor gene that is frequently targeted in colorectal tumourigenesis.
PRDM2 (show PRDM2 Antibodies), PRDM5, PRDM16 (show PRDM16 Antibodies) promoters are methylated and their expression is suppressed in lung cancer cells.
Data provide the first causal link between Prdm5 loss and intestinal carcinogenesis, and uncover an extensive and novel PRDM5 target repertoire likely facilitating the tumor-suppressive functions of PRDM5.
Prdm5 is expressed specifically in the area of the forming neurocranium during craniofacial development.
PRDM5 regulates the expression of components of both canonical and non canonical wnt (show WNT2 Antibodies) pathways and negatively modulates wnt (show WNT2 Antibodies) signaling in vivo
PRDM5 promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK (show MAPK8 Antibodies) expression and strategies targeting PRDM5 may be promising for the therapy of melanoma.
These data indicate how Prdm5 modulates transcription by interacting with factors involved in genome organization in mouse embryonic stem cells.
we show that Prdm5 controls both Collagen I transcription and fibrillogenesis by binding inside the Col1a1 gene body and maintaining RNA polymerase II occupancy
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis.
PR domain containing 5
, PR domain zinc finger protein 5-like
, PR domain zinc finger protein 5
, un-named hi61
, unm hi61
, PR domain-containing protein 5