Paired Box 4 (PAX4) ELISA Kits

PAX4 is a member of the paired box (PAX) family of transcription factors. Additionally we are shipping PAX4 Antibodies (71) and PAX4 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PAX4 5078 O43316
Anti-Mouse PAX4 PAX4 18506 P32115
Anti-Rat PAX4 PAX4 83630 O88436
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Top PAX4 ELISA Kits at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human
  96 Tests Log in to see 31 to 41 Days
$728.20
Details
Human < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Please inquire
  10 reactions Log in to see 4 to 6 Days
$549.00
Details

More ELISA Kits for PAX4 Interaction Partners

Human Paired Box 4 (PAX4) interaction partners

  1. genetic association studies in population in Republic of Korea: Data suggest that SNPs in PAX4 and GLP1R (show GLP1R ELISA Kits) are associated with type 2 diabetes (T2D) in the population studied. In genome-wide associations, PAX4 Arg192His increased risk of T2D; GLP1R (show GLP1R ELISA Kits) Arg131Gln decreased risk of T2D. (PAX4 = paired box 4 protein; GLP1R (show GLP1R ELISA Kits) = glucagon-like peptide 1 receptor (show GLP1R ELISA Kits))

  2. The rs10229583 polymorphism near PAX4 is associated with gestational diabetes mellitus in Chinese women.

  3. Study identified the association of a PAX4 Asian-specific missense variant rs2233580 with type 2 diabetes in an exome-chip association analysis, supporting the involvement of PAX4 in the pathogenesis of type 2 diabetes.

  4. Viability of beta-cell was reduced under glucotoxic stress condition for the cells overexpressing either PAX4 R192H or PAX4 P321H or both. Thus these PAX4 polymorphisms may increase T2D risk by defective transcription regulation of target genes and/or decreased beta-cell survival in high glucose condition.

  5. PAX4 IVS7-1G>A contributes to the pathogenesis of diabetes in this maturity-onset diabetes of the young, type 9 family through beta-cell dysfunction

  6. The PAX4 variant rs6467136 was associated with the therapeutic effect of rosiglitazone in Chinese T2DM patients.

  7. PAX4-miR (show MLXIP ELISA Kits)-144/451-ADAMs axis regulates human epithelial cancer metastasis

  8. These data suggest that acute PAX4 overexpression can reduce expression of aristaless related homeobox and glucagon (show GCG ELISA Kits) during embryonic stem cell differentiation resulting in improved numbers of unihormonal insulin (show INS ELISA Kits)-positive cells.

  9. Tph1 (show TPH1 ELISA Kits) and increased EC cell number occurred before the onset of obesity and hyperleptinemi. In addition, leptin (show LEP ELISA Kits) deficiency was associated with reduced Pax4 mRNA, oral leptin (show LEP ELISA Kits) treatment enhanced both Tph1 (show TPH1 ELISA Kits) and Pax4 mRNA.

  10. MAFA nuclear expression in pancreatic alpha and beta cells, and the percentage of alpha cells expressing PAX4 are altered in patients with type 2 diabetes.

Mouse (Murine) Paired Box 4 (PAX4) interaction partners

  1. Down-regulation of PAX4 or its target gene encoding the p97/VCP (show vcp ELISA Kits) ATPase (show DNAH8 ELISA Kits) reduced myofibril disassembly.

  2. Ectopic expression of Pax4 in pancreatic delta cells results in beta-like cell neogenesis.

  3. The coordinated regulation of distinct cellular pathways particularly related to ER homeostasis by PAX4 not achieved by the mutant variant PAX4R129W alleviates beta cell degeneration and protects against diabetes mellitus.

  4. This work establishes the existence of a bona fide PAX4-enriched cell subpopulation nested within pancreatic islets that can expand in periods of increased functional demands, and exhibit improved viability in response to pathophysiological situations.

  5. Pax4 expression is not sufficient to transduce pancreatic alpha cells into beta cells. Overexpression of Pax4 in alpha cells may not increase functional beta cell number in diabetic patients

  6. Adult glucagon (show GCG ELISA Kits) producing cells can be converted into beta-like cells upon Pax4 misexpression.

  7. RBM4 promoted insulin (show INS ELISA Kits) gene expression by altering the isoform balance of the transcription factors Isl1 (show ISL1 ELISA Kits) and Pax4 via alternative splicing control.

  8. these finding demonstrate that, downstream of Neurog3 (show NEUROG3 ELISA Kits), the specification of a subset of enteroendocrine subtypes relies on both Arx and Pax4, while others depend only on Arx or Pax4.

  9. Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor-kappaB target genes while increasing Bcl-2 (show BCL2 ELISA Kits) levels.

  10. Pax4 has a role in facilitating embryonic stem cell differentiation into the pancreatic lineage

PAX4 Antigen Profile

Antigen Summary

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.

Gene names and symbols associated with Paired Box 4 (PAX4) ELISA Kits

  • paired box 4 (PAX4) antibody
  • paired box 4 (Pax4) antibody
  • KPD antibody
  • MODY9 antibody
  • Pax-4 antibody
  • PAX4 antibody

Protein level used designations for Paired Box 4 (PAX4) ELISA Kits

paired box gene 4 , paired box protein Pax-4 , paired domain gene 4 , paired box 4 , paired-box gene 4 , paired box protein Pax-4-like

GENE ID SPECIES
5078 Homo sapiens
18506 Mus musculus
83630 Rattus norvegicus
472503 Pan troglodytes
482268 Canis lupus familiaris
554328 Ovis aries
698351 Macaca mulatta
100137394 Papio anubis
100354681 Oryctolagus cuniculus
100402138 Callithrix jacchus
100588587 Nomascus leucogenys
526172 Bos taurus
100715909 Cavia porcellus
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