anti-Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Antibodies

PNPLA2 encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Additionally we are shipping Patatin-Like phospholipase Domain Containing 2 Kits (43) and Patatin-Like phospholipase Domain Containing 2 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNPLA2 57104 Q96AD5
PNPLA2 66853 Q8BJ56
PNPLA2 361676 P0C548
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Top anti-Patatin-Like phospholipase Domain Containing 2 Antibodies at antibodies-online.com

Showing 10 out of 180 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN190844 (0.5µg/ml) staining of Human Adipose lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN190844 (2.5µg/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, WB ABIN334462 (0.2µg/ml) staining of Human Adipose lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IP, IHC, WB Western blot analysis of ATGL expression in rat kidney tissue lysate. 100 μg 2 to 3 Days
$245.00
Details
Cow Goat Un-conjugated ELISA, IHC, IHC (p) Human Heart (formalin-fixed, paraffin-embedded) stained with PNPLA2 antibody ABIN337131 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-PNPLA2 / ATGL antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Cow Goat Un-conjugated IHC (p), WB   0.1 mg 4 to 8 Days
$462.00
Details
Human Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Horse Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of ATGL using HuvEc whole  lysates. ABIN6277936 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details

Top referenced anti-Patatin-Like phospholipase Domain Containing 2 Antibodies

  1. Human Monoclonal PNPLA2 Primary Antibody for IHC (p), ELISA - ABIN534872 : Zimmermann, Strauss, Haemmerle, Schoiswohl, Birner-Gruenberger, Riederer, Lass, Neuberger, Eisenhaber, Hermetter, Zechner: Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. in Science (New York, N.Y.) 2004 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal PNPLA2 Primary Antibody for WB - ABIN1881664 : Kamikubo, Kai, Tsuji-Naito, Akagawa: β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes. in Molecular nutrition & food research 2017 (PubMed)

  3. Human Polyclonal PNPLA2 Primary Antibody for ELISA - ABIN547867 : Schoenborn, Heid, Vollmert, Lingenhel, Adams, Hopkins, Illig, Zimmermann, Zechner, Hunt, Kronenberg: The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. in Diabetes 2006 (PubMed)

  4. Polyclonal PNPLA2 Primary Antibody for WB - ABIN540337 : Haemmerle, Lass, Zimmermann, Gorkiewicz, Meyer, Rozman, Heldmaier, Maier, Theussl, Eder, Kratky, Wagner, Klingenspor, Hoefler, Zechner: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. in Science (New York, N.Y.) 2006 (PubMed)

  5. Cow (Bovine) Polyclonal PNPLA2 Primary Antibody for ELISA, WB - ABIN548226 : Steinberg, Kemp, Watt: Adipocyte triglyceride lipase expression in human obesity. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)

  6. Human Polyclonal PNPLA2 Primary Antibody for ICC, IF - ABIN188930 : Hu, Cui, Liu, Wang: Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells. in Oncotarget 2017 (PubMed)

  7. Human Monoclonal PNPLA2 Primary Antibody for CyTOF, FACS - ABIN4899287 : He, Wu, Gong, Luo, Zhang, Li, Lu, Wei, Yang: Enhanced efficacy of combination therapy with adeno‑associated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma. in Molecular medicine reports 2014 (PubMed)

More Antibodies against Patatin-Like phospholipase Domain Containing 2 Interaction Partners

Human Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. ATGL is highly expressed in hepatocellular carcinoma (HCC) tissues and predicts a poor prognosis. ATGL promotes HCC cell growth by maintaining elevated levels of diacylglycerol and free fatty acids in vitro and in vivo.

  2. Obese patients had a decrease in ATGL expression in subcutaneous adipose tissue.

  3. loss of ATGL may thus increase cancer aggressiveness by activation of pro-oncogenic signaling via SRC kinase and increased levels of bioactive lipids.

  4. Evidence for a previously uncovered tumor-suppressor function of ATGL in hepatocellular carcinoma, with the outlined molecular mechanisms shedding light on new potential targets for anticancer therapy.

  5. No difference in the genotype frequency of rs7925131 or rs7942159 in PNPLA2 between the normal free fatty acids (FFA) group and the high FFA group in a Chinese Han population.

  6. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.

  7. Although we found evidence for moderate association between PNPLA2 tagSNPs and anthropometric and metabolic parameters in our cohort, no evidence for association between polymorphisms in the PNPLA2 gene and the presence and severity of non-alcoholic fatty liver disease was identified.

  8. Study reports the derivation of iPSCs from fibroblasts of two Neutral Lipid Storage Disease with Myopathy (NLSDM)patients carrying different ATGL mutations. These iPSCs exhibited defects in neutral lipid metabolism similar to those of NLSDM fibroblasts. NLSDM-iPSCs were able to undergo directed differentiation into cardiomyocytes.

  9. Thus, ATGL in leucocytes may be an important biomarker for the diagnosis of TGCV and our assay may provide insights into pathophysiology and elucidate the underlying mechanism of TGCV and related disorders.

  10. The ATGL gene was frequently deleted in various forms of human cancers and was associated with poor prognosis.

  11. a Snail1-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

  12. ABHD5 possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.

  13. Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 levels and death of RPE cells undergoing oxidative stress.

  14. Results suggest that increased adipose triglyceride lipase (ATGL) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).

  15. A missense mutation in PNPLA2 is the rare cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease.

  16. A novel deletion was identified in PNPLA2 protein from a patient with complete deficiency of adipose triglyceride lipase.

  17. Rab32 controls intracellular lipid accumulation through inducing lipolysis via enhancing ATGL expression indirectly.

  18. Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL).

  19. Authors show that rat ATGL, coactivated by rat CGI-58, efficiently hydrolyzes triglycerides and retinyl ester.

  20. PNPLA2 mutations were associated with an extended phenotype, including brain involvement in cases of neutral lipid-storage disease with myopathy.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. ATGL in brown adipose tissue is not a prerequisite for cold-induced thermogenesis in vivo.

  2. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.

  3. this study shows that long non-coding steroid receptor RNA activator promotes hepatic steatosis through repressing the expression of ATGL

  4. ATGL deficiency results in male infertility in mice.

  5. Loss of ATGL induces spontaneous development of pulmonary neoplasia in knockout mouse model.

  6. ATGL acts as an important upstream signaling node that, via SIRT1, increases autophagy/lipophagy as a means to promote hepatic lipid droplet catabolism.

  7. a Snail1-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

  8. CGI-58 regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL.

  9. Enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles which is HSL/ATGL-independent.

  10. The Atgl is down-regulated by the basal transcription factor Sp1 in preadipocytes and that the magnitude of down-regulation depends on interactions between Sp1 and peroxisome proliferator-activated receptor gamma (PPARgamma).

  11. TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs.

  12. G0S2 protein but not mRNA levels were reduced in the adipose tissue of ATGL-deficient mice, corroborating the involvement of ATGL in the stabilization of G0S2

  13. Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage.

  14. These data raise the possibility that ATGL deficiency could impair the renal fatty acid metabolism though inhibiting PPARalphaexpression, which may lead to lipid deposition and cell apoptosis of PCT, and finally contribute to the renal fibrosis and dysfunction

  15. Markers of mitochondrial content and respiration were increased in adipose tissue from ATGL knockout mice.

  16. ase. Similar changes of GPNMB and G0S2 expression were present in a human liposarcoma database. These results show that a previously-unknown, fully penetrant epistatic interaction between Pnpla2 and Lipe can cause liposarcoma in mice. DAKO mice provide a promising model for studying early premalignant changes that lead to late-onset malignant disease.

  17. Activities of adipose triglyceride lipase (ATGL), hormone sensitive lipolitic enzyme (HSL) and monoacylglycerol lipase (MGL) were significantly higher (51 %, 38 %, 49 %) in the DE group than the HF group (p < 0.05). MGL, there were no differences between the CO group, HF group, and DC group, with the DE group (70 %) being significantly higher (p < 0.05).

  18. ATGL activity is required for UCP1 activation in intact adipocytes. (Review)

  19. ATGL-dependent lipolysis plays a critical role in mediating diverse effects of FoxO proteins in the liver, including effects on gluconeogenic, glycolytic, and lipogenic gene expression and metabolism.

  20. ANGPTL8 is a stress-response protein that down-regulates expression of ATGL.

Cow (Bovine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.

Pig (Porcine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Results identified functional polymorphisms providing new evidence of PNPLA2 as an important candidate gene for fat deposition and carcass traits in pigs.

  2. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma to that of ATGL in adipocytes.

  3. analysis of porcine adipose triglyceride lipase (PNPLA2) gene

  4. JAK-STAT and MAPK signaling pathways, as well as PPAR gamma all played important roles in the ATGL expression mediated by leptin

  5. patatin-like phospholipase domain containing 2 gene (PNPLA2) is assiged to chromosome 2 in pigs.

  6. ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue.

Goat Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. the ATGL gene plays an important role in triglyceride lipolysis in GMECs; ATGL may be involved in lipid metabolism during lactation

Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Antigen Profile

Protein Summary

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.

Gene names and symbols associated with PNPLA2

  • patatin like phospholipase domain containing 2 (PNPLA2) antibody
  • patatin like phospholipase domain containing 2 (pnpla2) antibody
  • patatin-like phospholipase domain containing 2 (Pnpla2) antibody
  • 0610039C21Rik antibody
  • 1110001C14Rik antibody
  • Atgl antibody
  • iPLA2zeta antibody
  • PEDF-R antibody
  • pnpla2 antibody
  • RGD1309044 antibody
  • TTS-2.2 antibody
  • TTS2 antibody

Protein level used designations for PNPLA2

IPLA2-zeta , TTS2.2 , adipose triglyceride lipase , calcium-independent phospholipase A2 , desnutrin , patatin-like phospholipase domain containing protein 2 , patatin-like phospholipase domain-containing protein 2 , pigment epithelium-derived factor , transport-secretion protein 2.2 , triglyceride hydrolase , patatin-like phospholipase domain containing 2 , transport-secretion protein , PNPLA2/ATGL

GENE ID SPECIES
57104 Homo sapiens
611403 Canis lupus familiaris
780152 Xenopus (Silurana) tropicalis
100219060 Taeniopygia guttata
100294555 Meleagris gallopavo
66853 Mus musculus
361676 Rattus norvegicus
431066 Gallus gallus
508493 Bos taurus
100049704 Sus scrofa
100860889 Capra hircus
101123166 Ovis aries
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