Patatin-Like phospholipase Domain Containing 2 Proteins (PNPLA2)

Human Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

1. No difference in the genotype frequency of rs7925131 or rs7942159 in PNPLA2 between the normal free fatty acids (FFA) group and the high FFA group in a Chinese Han population.

2. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.

3. Although we found evidence for moderate association between PNPLA2 tagSNPs and anthropometric and metabolic parameters in our cohort, no evidence for association between polymorphisms in the PNPLA2 gene and the presence and severity of non-alcoholic fatty liver disease was identified.

4. Study reports the derivation of iPSCs from fibroblasts of two Neutral Lipid Storage Disease with Myopathy (NLSDM)patients carrying different ATGL mutations. These iPSCs exhibited defects in neutral lipid metabolism similar to those of NLSDM fibroblasts. NLSDM-iPSCs were able to undergo directed differentiation into cardiomyocytes.

5. Thus, ATGL in leucocytes may be an important biomarker for the diagnosis of TGCV and our assay may provide insights into pathophysiology and elucidate the underlying mechanism of TGCV and related disorders.

6. The ATGL gene was frequently deleted in various forms of human cancers and was associated with poor prognosis.

7. a Snail1 (show SNAI1 Proteins)-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

8. ABHD5 (show ABHD5 Proteins) possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.

9. Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 (show ALOX5 Proteins) expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 (show PTGR1 Proteins) levels and death of RPE (show RPE Proteins) cells undergoing oxidative stress.

10. Results suggest that increased adipose triglyceride lipase (ATGL) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).

Mouse (Murine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

1. ATGL in brown adipose tissue is not a prerequisite for cold-induced thermogenesis in vivo.

2. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.

3. this study shows that long non-coding steroid receptor (show ESR2 Proteins) RNA activator promotes hepatic steatosis through repressing the expression of ATGL

4. ATGL deficiency results in male infertility in mice.

5. Loss of ATGL induces spontaneous development of pulmonary neoplasia in knockout mouse model.

6. ATGL acts as an important upstream signaling node that, via SIRT1 (show SIRT1 Proteins), increases autophagy/lipophagy as a means to promote hepatic lipid droplet catabolism.

7. a Snail1 (show SNAI1 Proteins)-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

8. CGI-58 (show ABHD5 Proteins) regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL.

9. Enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles which is HSL (show LIPE Proteins)/ATGL-independent.

10. The Atgl is down-regulated by the basal transcription factor Sp1 (show SP1 Proteins) in preadipocytes and that the magnitude of down-regulation depends on interactions between Sp1 (show SP1 Proteins) and peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Proteins)).

Cow (Bovine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

1. Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.

Pig (Porcine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

1. Results identified functional polymorphisms providing new evidence of PNPLA2 as an important candidate gene for fat deposition and carcass traits in pigs.

2. Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Proteins)) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Proteins) regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL in adipocytes.

3. analysis of porcine adipose triglyceride lipase (PNPLA2) gene

4. JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) and MAPK (show MAPK1 Proteins) signaling pathways, as well as PPAR gamma (show PPARG Proteins) all played important roles in the ATGL expression mediated by leptin (show LEP Proteins)

5. patatin-like phospholipase domain containing 2 gene (PNPLA2) is assiged to chromosome 2 in pigs.

6. ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue.

Goat Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

1. the ATGL gene plays an important role in triglyceride lipolysis in GMECs; ATGL may be involved in lipid metabolism during lactation