anti-Paternally Expressed 3 (PEG3) Antibodies

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PEG3 5178 Q9GZU2
PEG3 18616 Q3URU2
PEG3 246361  
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Top anti-PEG3 Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PEG3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  A204 cell lysate PEG3 is strongly supported by BioGPS gene expression data to be expressed in Human A204 cells WB Suggested Anti-PEG3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: A204 cell lysate  PEG3 is strongly supported by BioGPS gene expression data to be expressed in Human A204 cells 100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with PEG3 antibody ABIN214135 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-PEG3 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. ... 100 μL 11 to 14 Days
$727.83
Details
Human Mouse Un-conjugated WB 100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of PEG3 using A549 whole cell lysates ABIN6272384 staining A549 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-PEG3 Polyclonal Antibody, Unconjugated (ABIN735653) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL 14 to 21 Days
$428.45
Details

Top referenced anti-PEG3 Antibodies

  1. Human Polyclonal PEG3 Primary Antibody for IF (p), IHC (p) - ABIN735653 : Ge, Liang, Luo, Wei, Han, Schatten, Sun, Zhang: Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice. in Reproductive biology and endocrinology : RB&E 2014 (PubMed)
    Show all 2 Pubmed References

More Antibodies against PEG3 Interaction Partners

Human Paternally Expressed 3 (PEG3) interaction partners

  1. Soluble matrix-derived cues being transduced downstream of receptor engagement converge upon a newly-discovered nexus of autophagic machinery consisting of Peg3 for endothelial cell autophagy and mitostatin for tumor cell mitophagy.

  2. Peg3 expression levels anti-correlate with pluripotency and increase gradually upon ESC differentiation. Moreover, downregulation of Peg3 enhances the efficiency of reprogramming of differentiated cells towards pluripotency.

  3. Data suggest that PEG3 is required for TFEB induction and nuclear translocation in a VEGFR2- and AMPK-dependent manner for decorin/decorin receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB = transcription factor EB; VEGFR2 = vascular endothelial growth factor receptor-2; AMPK = AMP-activated protein kinase)

  4. Peg3 transcriptionally modulates BECN1 activity.

  5. Data indicate that a set of cis-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain.

  6. In the current study, the authors have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3.

  7. A resident population of resident smooth muscle progenitor cells expressing PW1 was identified in pulmonary hypertension-associated vascular remodeling.

  8. PW1/Peg3 function is essential for conferring proper mesoangioblast competence and it's level in human mesoangioblasts may serve as a biomarker to identify donor populations for therapeutic application in muscular dystrophies.

  9. The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.

  10. Genetic translocations involving PEG3 gene is associated with mesenchymal hamartoma of the liver.

  11. we have unveiled a mechanism for a secreted proteoglycan in inducing Peg3, a master regulator of macroautophagy in endothelial cells

  12. Results show that a five percent increase in DNA methylation of PEG3 is associated with a 1.6-fold increase invasive cervical cancer (ICC) risk.

  13. None of the folate cycle genotypes in the mother or infant were related to the methylation of IGF2, PEG3, or LINE-1.

  14. PEG3 gene is imprinted, with preferential expression from the paternal allele in human placenta.

  15. mammalian imprinting utilizes Peg3/Pw1 to co-opt the Wnt pathway, thereby regulating development and glioma growth

  16. Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death

  17. These results support a model in which pEg3 contributes to the control of progression through mitosis by phosphorylation of the CDC25 phosphatases.

  18. Loss of PEG3 expression may be a frequent event in gynecologic cancers. Given the known role of PEG3 in p53-mediated apoptosis, it is possible that PEG3 functions as a tumor suppressor.

  19. These results suggest that pEg3 might play a role at the cell cortex during mitosis.

  20. Down-regulation of PEG3 due to loss of heterozygosity and promoter methylation is associated with ovarian cancers

Mouse (Murine) Paternally Expressed 3 (PEG3) interaction partners

  1. Maternal deletion of Peg3-DMR (differentially methylated region) caused significant effects on the activity of the paternal allele, 2-fold increase of Peg3 and Usp29 throughout various tissues and different developmental stages. These effects were unidirectional with the maternal allele influencing the paternal one. These results suggest the presence of trans-allelic regulation associated with the Peg3-DMR.

  2. YY1 is mainly involved in controlling the transcriptional levels, but not the DNA methylation, of the Peg3 domain.

  3. this study suggests that Peg3 may function as a direct transcriptional regulator for Oxtr expression that acts to moderate the milk letdown process.

  4. Data shows that loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers

  5. Transcription driven by the alternative promoter U1 is required for oocyte-specific DNA methylation setting on the Peg3 locus.

  6. The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease in growth rates for both males and females, while the mutants with biallelic expression of Peg3 and Usp29 resulted in an increased growth rate of female mice only

  7. The Peg3 locus may have evolved to an imprinted domain to cope with both parental and sexual conflicts.

  8. PW1-positive cells were highly proliferative in comparison to PW1neg endothelial cells and were able to form colonies when seeded at clonal dilution.

  9. PW1/Peg3 is a reliable marker of the full population of follicle stem cells and reveal a novel CD34- bulge stem-cell population.

  10. Data suggest that the upregulations of Myb and Peg3 are likely the key anti-cancer events of EGCG in vivo.

  11. Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting, has been demonstrated for Peg3 gene.

  12. Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3).

  13. orientation of the Peg3-ICR may play no role in its allele-specific DNA methylation

  14. The results indicate that PW1 is a co-regulator of the beta cell cycle and can thus be considered a novel therapeutic target in diabetes.

  15. This study demonstrated the existence of a novel population of resident adult cardiac stem cells expressing PW1(+) and their involvement in fibrotic remodeling after MI.

  16. promoters of Peg3 derive sexually biased and tissue-specific expression patterns

  17. Our study also identified the imprinting control region (ICR) of H19 as a genomic target. According to the results, PEG3 binds to a specific sequence motif located between the 3(rd) and 4(th) CTCF binding sites of the H19-ICR. PEG3 also binds to the active maternal allele of the H19-ICR.

  18. These results support a general role for Pw1/Peg3 in the regulation of body growth but not maternal care and lactation.

  19. Data indicate that a set of cis-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain.

  20. Data show that bisperoxovanadium (BpV) treatment induces specific epigenetic modifications at the promoter regions of genes associated with stem cell fate, including Sca-1 and Pw1.

Cow (Bovine) Paternally Expressed 3 (PEG3) interaction partners

  1. the expression of PEG3 domain genes within the maternal placenta is not significantly affected by the MIMT1Del mutation and alterations in PEG3 domain gene expression on the fetal side

  2. Data show that a 110 kb microdeletion in the maternally imprinted PEG3 domain that results in a loss of paternal MIMT1 expression and causes late term abortion and stillbirth.

  3. Peg3 was seriously demethylated or showed aberrant methylation patterns in four aborted clones.

  4. PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR), but the PEG3-CpG island is the only DMR that is conserved among these three species.

Pig (Porcine) Paternally Expressed 3 (PEG3) interaction partners

  1. Porcine skeletal muscle-derived PW1(pos)/Pax7(neg) interstitial cells are a source of stem/progenitor cells.

  2. Expression profiling of day 30 swine parthenotes and control fetal tissues supports conserved maternal imprinting (paternal expression) in whole brain, carcass, liver and placentae.

  3. The PEG3 gene expression was not affected by day of pregnancy or breed.

  4. For PEG3, pigs expressed the paternal allele in skeletal muscle, liver, spleen, kidney, and uterus, but biallele in heart, lung, fat, stomach, small intestine, and ovary.

PEG3 Antigen Profile

Protein Summary

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PEG3

  • paternally expressed 3 (PEG3) antibody
  • paternally expressed 3 (Peg3) antibody
  • paternally-expressed gene 3 protein (LOC100448879) antibody
  • AL022617 antibody
  • ASF-1 antibody
  • End4 antibody
  • Gcap4 antibody
  • mKIAA0287 antibody
  • PEG3 antibody
  • Pw1 antibody
  • Zfp102 antibody
  • ZKSCAN22 antibody
  • ZNF904 antibody
  • ZSCAN24 antibody

Protein level used designations for PEG3

Kruppel-type zinc finger protein , paternally-expressed gene 3 protein , zinc finger and SCAN domain-containing protein 24 , granule cell antiserum positive 4 , paternally expressed gene 3 , zinc-finger protein , paternally expressed 3 , paternally-expressed gene 3 protein-like , Paternally-expressed gene 3 protein

GENE ID SPECIES
5178 Homo sapiens
18616 Mus musculus
246361 Rattus norvegicus
444864 Bos taurus
469030 Pan troglodytes
476371 Canis lupus familiaris
707825 Macaca mulatta
100448879 Pongo abelii
100505405 Ovis aries
100510800 Felis catus
100522552 Sus scrofa
100341995 Oryctolagus cuniculus
100051103 Equus caballus
100987733 Pan paniscus
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