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Study using whole blood of septic shock patients and healthy volunteers as well as an in vitro model that mimics immune alterations found in patients revealed that altered immune cells still have the ability to produce PTX3 in response to an inflammatory trigger, and therefore circulating white blood cell subset could be responsible of the sustained PTX3 plasma levels over the first days of sepsis setting.
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Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy.
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In chemico experiments by adding recombinant human PTX3 to supersaturated calcium and oxalate solutions revealed that PTX3, but not isomolar concentrations of albumin, dose-dependently inhibited crystal growth.
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altered PTX3 systemic levels, determined by genetic variations and/or low-grade chronic inflammation, can also impact the growth and development of the follicle and affect the incidence of ovarian disorders.
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This study showed a significant association between PTX3 rs1840680 polymorphisms and the susceptibility of pulmonary aspergillosis in patients with chronic obstructive pulmonary disease.
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impact of PTX3 and PTX3-derived molecules on the angiogenic, inflammatory, and tumorigenic activity of FGF2
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Pentraxin 3 (PTX-3) showed prognostic value for the prediction of short- and mid-term all-cause mortality in patients suffering from sepsis and septic shock according to the latest Sepsis-3 criteria.
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Investigated alveolar expression of neutrophil enzymes and PTX3 to distinguish chronic lung allograft dysfunction subtypes.
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These findings suggest that PTX3 plays a key role in the development of obesity by enhancing adipocyte differentiation and lipid synthesis via NPY/NPYR signaling. These observations provide a mechanistic explanation for the adipogenesis mediated by PTX3.
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In HCV patients the PTX3 level increased in parallel with the METAVIR histological score of activity, being independently associated with the METAVIR fibrosis score (P < 0.001).
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patients PTX-3 level increase was associated with violation of lipid and carbohydrate exchanges
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The levels of serum PTX3, vWf and CXCL13 increased in patients with Unstable Angina Pectoris.
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PTX-3 significantly predicts disease severity and mortality in sepsis
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There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke.
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Although inflammation has an important role in diabetic retinopathy DR), biomarkers reflecting inflammation is not sufficient to predict development and progression of DR; but follow up with PTX-3 levels along with ophthalmological evaluation may be useful. A single determination may not reflect the variations over time, so repeat measures may provide knowledge if PTX-3 is just a biomarker or has a causal role.
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PTX3 and IL36alpha serum levels are increased in systemic lupus erythematosus patients when compared to normal control subjects
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Studied the relationship between serum pentraxin-3 (PTX3) levels and flow-mediated dilation results in patients with dipper and non-dipper hypertension (HT); found serum pentraxin-3 levels were higher in patients with non-dipper HT compared to dipper hypertension.
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PTX3 rs1840680 genotype AA is associated with increased risk of active pulmonary tuberculosis
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combination of lower PTX3 and Nrf2 immunohistochemical expression may be important in offering a better prognosis in gliomas, although the detailed mechanism is yet to be elucidated
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these findings suggest that PTX3 is an important mediator of lung cancer progression, and dePTX3 by TM enhances the anticancer effects of Cis. The deglycosylation in chemotherapy may represent a potential novel therapeutic strategy against lung cancer.