Pentraxin 3 Proteins (PTX3)

Human Pentraxin 3 (PTX3) interaction partners

1. patients PTX-3 level increase was associated with violation of lipid and carbohydrate exchanges

2. The levels of serum PTX3, vWf and CXCL13 increased in patients with Unstable Angina Pectoris.

3. PTX-3 significantly predicts disease severity and mortality in sepsis

4. There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke.

5. Although inflammation has an important role in diabetic retinopathy DR), biomarkers reflecting inflammation is not sufficient to predict development and progression of DR; but follow up with PTX-3 levels along with ophthalmological evaluation may be useful. A single determination may not reflect the variations over time, so repeat measures may provide knowledge if PTX-3 is just a biomarker or has a causal role.

6. PTX3 and IL36alpha serum levels are increased in systemic lupus erythematosus patients when compared to normal control subjects

7. Studied the relationship between serum pentraxin-3 (PTX3) levels and flow-mediated dilation results in patients with dipper and non-dipper hypertension (HT); found serum pentraxin-3 levels were higher in patients with non-dipper HT compared to dipper hypertension.

8. PTX3 rs1840680 genotype AA is associated with increased risk of active pulmonary tuberculosis

9. combination of lower PTX3 and Nrf2 immunohistochemical expression may be important in offering a better prognosis in gliomas, although the detailed mechanism is yet to be elucidated

10. these findings suggest that PTX3 is an important mediator of lung cancer progression, and dePTX3 by TM enhances the anticancer effects of Cis. The deglycosylation in chemotherapy may represent a potential novel therapeutic strategy against lung cancer.

11. In summary, this study provides in vivo evidence that PTX3 is enhanced during ENL but not in reversal reaction.

12. PTX3 plays a critical role in the regulation of pulp inflammatory processes.

13. Studied influence of high-intensity interval exercise versus continuous moderate-intensity exercise on plasma levels of pentraxin 3 (PTX3) and glucose.

14. PTX-3 and MASP-3 enhanced prediction of myocardial infarction compared to the traditional Framingham risk score alone

15. PTX3 might be an early marker of cardiovascular mortality in patients with advanced chronic kidney disease yet before the increase of specific marker for systemic inflammation like hsCRP.

16. These findings reveal that the CRP- and PTX3-binding characteristics of FHL-1 differ from those of FH, likely underpinning independent immune regulatory functions in the context of the human retina.

17. given that acute aerobic exercise reduced the ex vivo production of PTX3 in both groups

18. PTX3 is not suitable to serve as an indicator of thrombolytic efficacy and had no association with long-term prognosis in stroke patients receiving thrombolytic therapy.

19. Patients with TAO showed increased presence of PTX3 in orbital tissue and serum.

20. Data show that pentraxin-3 (PTX3) is not a biomarker of disease activity and cannot be used for the purpose.

Cow (Bovine) Pentraxin 3 (PTX3) interaction partners

1. there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region

Pig (Porcine) Pentraxin 3 (PTX3) interaction partners

1. MicroRNA-224 delays oocyte maturation through targeting Ptx3 in cumulus cells.

2. presence of PTX3 mRNA expression was detected in all the cardiac chambers sharing an increase after 3 weeks of pacing compared to controls

Mouse (Murine) Pentraxin 3 (PTX3) interaction partners

1. this study shows that PTX3 plays an important role in bone homeostasis and in proper matrix mineralization during fracture repair

2. PTX3 interacts with fibrinogen and collagen and, by dampening their pro-thrombotic effects, plays a protective role during arterial thrombosis.

3. determined that PTX3 was an important moderator of obesity; inflammation during pregnancy could lead to a significant increase in the levels of the inflammatory factor PTX3.

4. Alcoholic intoxication suppresses pentraxin 3 expression and contributes to exacerbation of sepsis.

5. PTX3 attenuates the production of murine myeloperoxidase-anti-neutrophil cytoplasmic antibody induced by aluminum salt adjuvant.

6. increased susceptibility to Aspergillus fumigatus correlates with downregulation of Ptx3 expression in calcineurin-deficient mice

7. Pneumococcal toxin pneumolysin was responsible for PTX3 expression and upregulated PTX3 expression via JNK MAPK signaling. These data implicate PTX3 as a novel therapeutic target for the control of acute inflammation by pneumococcus.

8. PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for marginal zone B cells.

9. PTX3 levels increase in the airways of patients with severe asthma and OVA-exposed mice. Deletion of PTX3 results in enhanced inflammation, airway hyper-responsiveness, and mucus production on OVA sensitization and challenge.On OVA exposure, CD4 T cells from Ptx3-/- mice exhibit an enhanced survival in contrast to Ptx3+/+ mice

10. PTX3 plays a non-redundant role in resistance against microbial pathogens and in the regulation of inflammation. (Review)

11. PTX3 produced from bone marrow-derived cells plays a crucial role in cardiac protection.

12. PTX3 expression is elevated in spinal cords during chronic relapsing EAE in Biozzi ABH mice, but the EAE severity and time course in PTX3-deficient mice did not differ from WT mice

13. Cardioprotective function of immunoproteasome-dependent PTX3 expression revealed a crucial mechanism of the stress-induced damage response in myocardial inflammation.

14. Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury.

15. Neisseria meningitidis is recognized by PTX3, which serves as an endogenous adjuvant against meningococcal infection.

16. These data suggest that the relative levels of SAP and PTX3 present at sites of fibrosis may have a significant effect on the ability of monocytes to differentiate into fibrocytes.

17. our study identified a previously undescribed pathogenic role of PTX3 during virus infection

18. PTX3 has a role in tissue remodeling and repair, involved in matrix and microbial recognition, which may be common, ancestral features of the humoral arm of innate immunity

19. The host-protective effects of PTX3 in sepsis are a result of its coaggregation with histones rather than its ability to mediate pattern recognition.

20. PTX3, an effector molecule belonging to the humoral arm of innate immunity, acts as an extrinsic oncosuppressor gene in mouse and man by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation.