Pentraxin 3 Proteins (PTX3)

Human Pentraxin 3 (PTX3) interaction partners

1. Data show that pentraxin-3 (PTX3) is not a biomarker of disease activity and cannot be used for the purpose.

2. PTX3 (show PITX3 Proteins) is positively regulated by chronic hyperglycemia but negatively regulated by aldosterone

3. treatment of human osteoblast primary cultures derived from young patients with anti-PTX3 (show PITX3 Proteins) antibody, osteoblasts lost the morphological and molecular features typical of mature osteoblasts, acquiring fibroblast-like shape and highly decreasing nuclear factor kappa-B ligand (RANKL (show TNFSF11 Proteins)) and RUNX2 (show RUNX2 Proteins) expression.

4. High PTX3 (show PITX3 Proteins) expression is associated with endothelial dysfunction during hemodialysis.

5. PTX3 (show PITX3 Proteins) might be an inflammatory biomarker for coronary artery disease. PTX3 (show PITX3 Proteins) was associated with the severity of coronary artery stenosis.

6. Results showed that increased PTX3 (show PITX3 Proteins) expression was significantly associated with tumor grade in human cervical cancer cells. It also demonstrated that PTX3 (show PITX3 Proteins) contributes to tumorigenesis and metastasis of cervical cancer cells.

7. serum PTX-3 (show PITX3 Proteins) level might be a significant mediator in childhood-onset systemic lupus erythematosus (cSLE); the results support that PTX3 (show PITX3 Proteins) reflects active cutaneous vasculitis in cSLE and correlates with disease activity.

8. Serum PTX3 (show PITX3 Proteins) is related to the severity of autoimmune hepatitis, the presence of acute-on-chronic liver failure and 90-day mortality.

9. Knocking down long pentraxin-3 (PTX3) or vimentin (show VIM Proteins) repressed oleate-induced head and neck squamous cell carcinomas (HNSCCs) invasion.

10. Higher levels of PTX3 (show PITX3 Proteins) in women with preeclampsia were significantly associated with signs of adverse arterial effects during pregnancy.

Cow (Bovine) Pentraxin 3 (PTX3) interaction partners

1. there is an FGF2 (show FGF2 Proteins)-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region

Pig (Porcine) Pentraxin 3 (PTX3) interaction partners

1. MicroRNA-224 delays oocyte maturation through targeting Ptx3 in cumulus cells.

2. presence of PTX3 mRNA expression was detected in all the cardiac chambers sharing an increase after 3 weeks of pacing compared to controls

Mouse (Murine) Pentraxin 3 (PTX3) interaction partners

1. determined that PTX3 (show PITX3 Proteins) was an important moderator of obesity; inflammation during pregnancy could lead to a significant increase in the levels of the inflammatory factor PTX3 (show PITX3 Proteins).

2. Alcoholic intoxication suppresses pentraxin 3 expression and contributes to exacerbation of sepsis.

3. PTX3 (show PITX3 Proteins) attenuates the production of murine myeloperoxidase (show MPO Proteins)-anti-neutrophil cytoplasmic antibody induced by aluminum salt adjuvant.

4. increased susceptibility to Aspergillus fumigatus correlates with downregulation of Ptx3 expression in calcineurin-deficient mice

5. Pneumococcal toxin pneumolysin was responsible for PTX3 (show PITX3 Proteins) expression and upregulated PTX3 (show PITX3 Proteins) expression via JNK (show MAPK8 Proteins) MAPK (show MAPK1 Proteins) signaling. These data implicate PTX3 (show PITX3 Proteins) as a novel therapeutic target for the control of acute inflammation by pneumococcus.

6. PTX3 (show PITX3 Proteins) may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for marginal zone B cells.

7. PTX3 (show PITX3 Proteins) levels increase in the airways of patients with severe asthma and OVA-exposed mice. Deletion of PTX3 (show PITX3 Proteins) results in enhanced inflammation, airway hyper-responsiveness, and mucus production on OVA sensitization and challenge.On OVA exposure, CD4 (show CD4 Proteins) T cells from Ptx3 (show PITX3 Proteins)-/- mice exhibit an enhanced survival in contrast to Ptx3 (show PITX3 Proteins)+/+ mice

8. PTX3 (show PITX3 Proteins) plays a non-redundant role in resistance against microbial pathogens and in the regulation of inflammation. (Review)

9. PTX3 (show PITX3 Proteins) produced from bone marrow-derived cells plays a crucial role in cardiac protection.

10. PTX3 (show PITX3 Proteins) expression is elevated in spinal cords during chronic relapsing EAE in Biozzi ABH (show ALKBH Proteins) mice, but the EAE severity and time course in PTX3 (show PITX3 Proteins)-deficient mice did not differ from WT mice