Pentraxin 3 Proteins (PTX3)

Human Pentraxin 3 (PTX3) interaction partners

1. Study using whole blood of septic shock patients and healthy volunteers as well as an in vitro model that mimics immune alterations found in patients revealed that altered immune cells still have the ability to produce PTX3 in response to an inflammatory trigger, and therefore circulating white blood cell subset could be responsible of the sustained PTX3 plasma levels over the first days of sepsis setting.

2. Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy.

3. In chemico experiments by adding recombinant human PTX3 to supersaturated calcium and oxalate solutions revealed that PTX3, but not isomolar concentrations of albumin, dose-dependently inhibited crystal growth.

4. altered PTX3 systemic levels, determined by genetic variations and/or low-grade chronic inflammation, can also impact the growth and development of the follicle and affect the incidence of ovarian disorders.

5. This study showed a significant association between PTX3 rs1840680 polymorphisms and the susceptibility of pulmonary aspergillosis in patients with chronic obstructive pulmonary disease.

6. impact of PTX3 and PTX3-derived molecules on the angiogenic, inflammatory, and tumorigenic activity of FGF2

7. Pentraxin 3 (PTX-3) showed prognostic value for the prediction of short- and mid-term all-cause mortality in patients suffering from sepsis and septic shock according to the latest Sepsis-3 criteria.

8. Investigated alveolar expression of neutrophil enzymes and PTX3 to distinguish chronic lung allograft dysfunction subtypes.

9. These findings suggest that PTX3 plays a key role in the development of obesity by enhancing adipocyte differentiation and lipid synthesis via NPY/NPYR signaling. These observations provide a mechanistic explanation for the adipogenesis mediated by PTX3.

10. In HCV patients the PTX3 level increased in parallel with the METAVIR histological score of activity, being independently associated with the METAVIR fibrosis score (P < 0.001).

11. patients PTX-3 level increase was associated with violation of lipid and carbohydrate exchanges

12. The levels of serum PTX3, vWf and CXCL13 increased in patients with Unstable Angina Pectoris.

13. PTX-3 significantly predicts disease severity and mortality in sepsis

14. There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke.

15. Although inflammation has an important role in diabetic retinopathy DR), biomarkers reflecting inflammation is not sufficient to predict development and progression of DR; but follow up with PTX-3 levels along with ophthalmological evaluation may be useful. A single determination may not reflect the variations over time, so repeat measures may provide knowledge if PTX-3 is just a biomarker or has a causal role.

16. PTX3 and IL36alpha serum levels are increased in systemic lupus erythematosus patients when compared to normal control subjects

17. Studied the relationship between serum pentraxin-3 (PTX3) levels and flow-mediated dilation results in patients with dipper and non-dipper hypertension (HT); found serum pentraxin-3 levels were higher in patients with non-dipper HT compared to dipper hypertension.

18. PTX3 rs1840680 genotype AA is associated with increased risk of active pulmonary tuberculosis

19. combination of lower PTX3 and Nrf2 immunohistochemical expression may be important in offering a better prognosis in gliomas, although the detailed mechanism is yet to be elucidated

20. these findings suggest that PTX3 is an important mediator of lung cancer progression, and dePTX3 by TM enhances the anticancer effects of Cis. The deglycosylation in chemotherapy may represent a potential novel therapeutic strategy against lung cancer.

Cow (Bovine) Pentraxin 3 (PTX3) interaction partners

1. there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region

Pig (Porcine) Pentraxin 3 (PTX3) interaction partners

1. MicroRNA-224 delays oocyte maturation through targeting Ptx3 in cumulus cells.

2. presence of PTX3 mRNA expression was detected in all the cardiac chambers sharing an increase after 3 weeks of pacing compared to controls

Mouse (Murine) Pentraxin 3 (PTX3) interaction partners

1. On the basis of the results of this study, it was hypothesized that miR-150 could possibly maintain endothelial cell function and suppress vascular remodeling by inhibiting PTX3 through the NF-kappaB signaling pathway in mice with ACS.

2. Pentraxin 3 is a key regulator of angiogenesis and is emerging as a promising target for cerebrovascular repair after stroke. Restoration of cerebral blood flow (CBF) and angiogenesis are crucial for brain repair and functional recovery after cerebral ischaemia.

3. Ptx3 protein was undetectable in tubular cells and urine of wild-type mice. However, its levels increased within 3 weeks of diet-induced hyperoxaluria-related nephrocalcinosis. Genetic ablation of Ptx3 in nephrocalcinosis un-susceptible B6;129 mice was sufficient to raise the oxalate nephropathy phenotype observed in susceptible strains, concluding that Ptx3 is an endogenous inhibitor of calcium oxalate crystal growth.

4. These findings suggest that PTX3 plays a key role in the development of obesity by enhancing adipocyte differentiation and lipid synthesis via NPY/NPYR signaling. These observations provide a mechanistic explanation for the adipogenesis mediated by PTX3.

5. this study shows that PTX3 plays an important role in bone homeostasis and in proper matrix mineralization during fracture repair

6. PTX3 interacts with fibrinogen and collagen and, by dampening their pro-thrombotic effects, plays a protective role during arterial thrombosis.

7. determined that PTX3 was an important moderator of obesity; inflammation during pregnancy could lead to a significant increase in the levels of the inflammatory factor PTX3.

8. Alcoholic intoxication suppresses pentraxin 3 expression and contributes to exacerbation of sepsis.

9. PTX3 attenuates the production of murine myeloperoxidase-anti-neutrophil cytoplasmic antibody induced by aluminum salt adjuvant.

10. increased susceptibility to Aspergillus fumigatus correlates with downregulation of Ptx3 expression in calcineurin-deficient mice

11. Pneumococcal toxin pneumolysin was responsible for PTX3 expression and upregulated PTX3 expression via JNK MAPK signaling. These data implicate PTX3 as a novel therapeutic target for the control of acute inflammation by pneumococcus.

12. PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for marginal zone B cells.

13. PTX3 levels increase in the airways of patients with severe asthma and OVA-exposed mice. Deletion of PTX3 results in enhanced inflammation, airway hyper-responsiveness, and mucus production on OVA sensitization and challenge.On OVA exposure, CD4 T cells from Ptx3-/- mice exhibit an enhanced survival in contrast to Ptx3+/+ mice

14. PTX3 plays a non-redundant role in resistance against microbial pathogens and in the regulation of inflammation. (Review)

15. PTX3 produced from bone marrow-derived cells plays a crucial role in cardiac protection.

16. PTX3 expression is elevated in spinal cords during chronic relapsing EAE in Biozzi ABH mice, but the EAE severity and time course in PTX3-deficient mice did not differ from WT mice

17. Cardioprotective function of immunoproteasome-dependent PTX3 expression revealed a crucial mechanism of the stress-induced damage response in myocardial inflammation.

18. Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury.

19. Neisseria meningitidis is recognized by PTX3, which serves as an endogenous adjuvant against meningococcal infection.

20. These data suggest that the relative levels of SAP and PTX3 present at sites of fibrosis may have a significant effect on the ability of monocytes to differentiate into fibrocytes.