Peptidase D Proteins (PEPD)

PEPD encodes a member of the peptidase family. Additionally we are shipping Peptidase D Antibodies (51) and Peptidase D Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PEPD 5184 P12955
PEPD 18624 Q11136
PEPD 292808 Q5I0D7
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Top Peptidase D Proteins at

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 13 to 16 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human S tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 15 to 16 Days

PEPD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Peptidase D (PEPD) Interaction Partners

Human Peptidase D (PEPD) interaction partners

  1. PEPD directly binds to p53 in the nucleus and cytoplasm and suppresses both transcription-dependent and transcription-independent activities of p53, which does not require PEPD enzymatic activity.

  2. Increased serum prolidase activity and decreased antioxidant levels are likely to be a results of increased of oxidative stress levels in obese subjects

  3. Serum prolidase activity is reduced in scleroderma patients, especially in diffuse form.

  4. Increased levels of serum prolidase activity are associated with the severity of developmental dysplasia of the hip.

  5. High resolution X-ray crystallographic models of substrate and product binding in the active site of human prolidase.

  6. We report here that by introducing either the A252R or P365R substitution mutation, the structural changes affecting catalytic turnover rate and substrate binding affinity are valuable in improving the catalytic activity of human prolidase towards toxic organophosphorus compound hydrolysis.

  7. In ankylosing spondylitis, serum prolidase level was successful in measuring disease activity

  8. there is an independent relationship of aortic prolidase activity and aortic prolidase immunostaining with aortic stiffness beta index in patients who underwent coronary artery bypass grafting

  9. Prolidase activity decreases in patients with chronic obstructive pulmonary disease.

  10. absence of prolidase activity in pterygium tissue indicates that there is no collagen turnover in this tissue

  11. Decreased serum prolidase activity may be associated with knee osteoarthritis

  12. The association between the PEPD genetic variant and the risk of T2D was modulated by n-3 fatty acids. Higher n-3 fatty acids may abolish the adverse effect of the risk allele at PEPD for T2D

  13. Prolidase was required for IFNAR1 maturation and accumulation, activation of IFNbeta-stimulated gene induction, and IFN-I-dependent viral control.

  14. Levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma.

  15. Serum prolidase level was significantly higher in schizophrenia patients compared to the controls.

  16. There may be an ethnic- and/or sex-specific association of the PEPD rs731839 single nucleotide polymorphism and serum lipid levels in Mulao and Han populations

  17. Prolidase is required for early trafficking events during influenza A virus entry.

  18. High prolidase activity may indicate critical biological activities relevant to pathological events in Behcet's disease, and this activity may be a biological indicator of disease.

  19. Significantly lower prolidase activity in patients with benign joint hypermobility syndrome suggests that prolidase may affect the collagen metabolism and cause hyperlaxity.

  20. Serum C4b, FN, and PEPD are associated with the pathological changes of pulmonary tuberculosis.

Mouse (Murine) Peptidase D (PEPD) interaction partners

  1. The findings identify peptidase D, an ubiquitously expressed intracellular peptidase, as a potential novel marker of colitis.

  2. PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation

  3. The dark-like mutation causes cardiomyocyte hypertrophy due to loss-of-function of peptidase d (Pepd).

  4. NO stimulates prolidase activity by increasing serine/threonine phosphorylation through PKG-cGMP pathway

Peptidase D (PEPD) Protein Profile

Protein Summary

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Peptidase D Proteins (PEPD)

  • peptidase D (pepd)
  • peptidase D (pepD)
  • peptidase D (PEPD)
  • peptidase D L homeolog (pepd.L)
  • peptidase D (Pepd)
  • cb1000 protein
  • DDBDRAFT_0190220 protein
  • DDBDRAFT_0266378 protein
  • DDB_0190220 protein
  • DDB_0266378 protein
  • fj78g11 protein
  • MGC89151 protein
  • Pep-4 protein
  • Pep4 protein
  • prolidase protein
  • wu:fj78g11 protein

Protein level used designations for Peptidase D Proteins (PEPD)

peptidase D , X-Pro dipeptidase , aminoacyl-L-proline hydrolase , imidodipeptidase , proline dipeptidase , xaa-Pro dipeptidase , X-pro dipeptidase , peptidase 4 , prolidase

493456 Xenopus (Silurana) tropicalis
8616862 Dictyostelium discoideum AX4
5184 Homo sapiens
337498 Danio rerio
734463 Xenopus laevis
415776 Gallus gallus
615158 Bos taurus
18624 Mus musculus
292808 Rattus norvegicus
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