Phospholipase A2, Group III Proteins (PLA2G3)

Human Phospholipase A2, Group III (PLA2G3) interaction partners

1. Several hits were discovered, and data have been uploaded to PubChem. This study describes the first high-throughput optical screening assay for secreted phospholipase A2 inhibitors based on a phospholipid vesicle substrate

2. Studies indicate that the expression of secreted phospholipases A2 (sPLA2s), most notably the group IIA, III and X enzymes, is dysregulated in various malignant tissues.

3. Studies indicate that phospholipase A2 receptor 1 (PLA2R1 (show PLA2R1 Proteins)) may act as a clearance or signaling receptor for secreted phospholipase A2 (show YWHAZ Proteins) (sPLA2s (show PLA2G2D Proteins)).

4. Data indicate that the expression of genes encoding hGIIA, hGIII and hGX sPLA2s (show PLA2G2D Proteins) (PLA2G2A (show PLA2G2A Proteins), PLA2G3 and PLA2G10 (show PLA2G10 Proteins), respectively) in breast tumour biopsies differs from that in normal tissues.

5. we describe that PLA2G3 gene silencing produced a marked inhibition of xanthine/xanthine oxidase (show XDH Proteins) induced cell death, and that PLA2G3 polymorphisms are associated with Alzheimer disease in a Spanish case-control sample.

6. The availability of the human group III phospholipase A (show HRASLS Proteins)(2) (hIIIPLA(2)) amino acid sequence offers an opportunity to study its structural features by modeling.

7. Secreted PLA2 (show YWHAZ Proteins) III induces apoptosis of primary cortical neurons in culture by suppressing production of Bcl-xl (show BCL2L1 Proteins), promoting Bax (show BAX Proteins), augmenting caspase 3 (show CASP3 Proteins) and cleaving alpha-fodrin (show SPTAN1 Proteins).

8. Lys (show LYZ Proteins) 43 and Asp (show ASIP Proteins) 46 in rhUG are critical residues for the sPLA2 (show PLA2G2A Proteins)-inhibitory activity of UG

9. cellular arachidonate (AA) release and prostaglandin (PG) production are regulated by novel classes of secretory phospholipase A (show HRASLS Proteins)(2)s (sPLA(2 (show PLA2G2A Proteins))s), groups III and XII

10. sPLA(2 (show PLA2G2A Proteins))-III may have a role in cancer development by stimulating tumor cell growth and angiogenesis

Mouse (Murine) Phospholipase A2, Group III (PLA2G3) interaction partners

1. Findings show a key role of Pla2g3 on the reduction of IDE (show IDE Proteins), and suggest that cerebrum specific increase of Pla2g3 is involved in the initiation and/or progression of Alzheimer disease.

2. Data indicate a PLA2G3-lipocalin (show APOD Proteins)-type PGD2 synthase (L-PGDS)-PGD2 (show PTGDS Proteins) receptor DP1 (show PTGDR Proteins) loop that drives mast cell maturation.

3. the atypical sPLA2 (show PLA2G2A Proteins) family member sPLA2-III has a role in epididymal lipid homeostasis and its perturbation may lead to sperm dysfunction

4. sPLA(2 (show PLA2G2A Proteins))-III may have a role in cancer development by stimulating tumor cell growth and angiogenesis

5. This study showed that endogenous group III sPLA2 (show PLA2G2A Proteins) (PLA2G3) is expressed in mouse skin and that transgenic mice overexpressing human PLA2G3 spontaneously develop skin inflammation.