Placenta-Specific 1 Proteins (PLAC1)

Human Placenta-Specific 1 (PLAC1) interaction partners

1. The findings suggest a possible pathophysiological link between the development of Fetal growth restriction and the expression of PAPPA (show PAPPA Proteins), PAPPA2 (show PAPPA2 Proteins) and PLAC-1.

2. Screening for these five CTAs and PLAC1 by RTqPCR may offer a potentially valuable prognostic tool with good sensitivity and specificity in patients with Hepatocellular carcinoma (HCC (show FAM126A Proteins)) that may be enhanced by magneticactivated cell sorting .

3. Study revealed that PLAC1 expression was highly expressed in non-small cell lung cancer (NSCLC) tissues, suggesting that PLAC1 may be a prognostic factor and higher risk for NSCLC patients. PLAC1 was involved in regulation of the proliferation, migration, and invasion abilities of NSCLC cells partly through regulation of epithelial-mesenchymal transition and the AKT (show AKT1 Proteins) pathway.

4. There was no significant correlation of serum PLAC1 levels with race, age at diagnosis, body mass index (BMI) or the presence of metastatic disease. It remains to be determined whether PLAC1 serum levels can serve as a diagnostic biomarker for the presence or recurrence of disease post-surgery and/or therapy

5. this paper shows that PLAC1 immunization does not induce infertility in mice

6. Optimized protocol for soluble prokaryotic expression, purification and structural analysis of human placenta specific-1(PLAC1).

7. we show that PLAC1 transcript number is significantly negatively correlated with patient survival in our samples. Thus, we suggest that characterizing tumors for TP53 (show TP53 Proteins) mutation status, p53 (show TP53 Proteins) protein status and PLAC1 transcription could be used to predict likely prognosis and inform treatment options in patients diagnosed with serous ovarian cancer.

8. This study demonstrated that the protein expression of PLAC1 was significantly associated with decreased overall survival in patients with pancreatic ductal adenocarcinoma, indicating that it was a valuable prognostic marker for pancreatic ductal adenocarcinoma and might be a potential target for immunotherapy.

9. Plac1 plays a pivotal role in the progression of HCC (show FAM126A Proteins), and may serve as a novel therapeutic target for Hepatocellular carcinoma.

10. PLAC1 was mainly expressed in the human villous syncytiotrophoblast (STB) layer throughout gestation, and the expression level of PLAC1 was significantly elevated during human trophoblast syncytialization.

Mouse (Murine) Placenta-Specific 1 (PLAC1) interaction partners

1. Plac1 is abundantly expressed at the fetomaternal interface and in all trophoblast subtypes except in primary trophoblast giant cells. Plac1 knockdown retarded the progress of TS differentiation, indicating that Plac1 is necessary for normal trophoblast differentiation into various trophoblast subpopulations.

2. Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration

3. Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus.

4. Plac1 is a paternally imprinted, X-linked gene essential for normal placental and embryonic development.