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May play a role in placental development (By similarity).. Additionally we are shipping Placenta-Specific 1 Antibodies (21) and Placenta-Specific 1 Kits (6) and many more products for this protein.
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There was no significant correlation of serum PLAC1 levels with race, age at diagnosis, body mass index (BMI) or the presence of metastatic disease. It remains to be determined whether PLAC1 serum levels can serve as a diagnostic biomarker for the presence or recurrence of disease post-surgery and/or therapy
this paper shows that PLAC1 immunization does not induce infertility in mice
Optimized protocol for soluble prokaryotic expression, purification and structural analysis of human placenta specific-1(PLAC1).
we show that PLAC1 transcript number is significantly negatively correlated with patient survival in our samples. Thus, we suggest that characterizing tumors for TP53 (show TP53 Proteins) mutation status, p53 (show TP53 Proteins) protein status and PLAC1 transcription could be used to predict likely prognosis and inform treatment options in patients diagnosed with serous ovarian cancer.
This study demonstrated that the protein expression of PLAC1 was significantly associated with decreased overall survival in patients with pancreatic ductal adenocarcinoma, indicating that it was a valuable prognostic marker for pancreatic ductal adenocarcinoma and might be a potential target for immunotherapy.
Plac1 plays a pivotal role in the progression of HCC (show FAM126A Proteins), and may serve as a novel therapeutic target for Hepatocellular carcinoma.
PLAC1 was mainly expressed in the human villous syncytiotrophoblast (STB) layer throughout gestation, and the expression level of PLAC1 was significantly elevated during human trophoblast syncytialization.
PLAC1/CP1 provides a marker for identifying gastric cancers with poor prognosis, and suggest that PLAC1/CP1 may provide a useful target for immunotherapy.
Data suggests that PLAC1 plays an important role in human placental trophoblast invasion and migration.
This data suggests that the Epstein-Barr virus-induced PLAC1 is a member of the cancer/testis group of tumor antigens.
Plac1 is abundantly expressed at the fetomaternal interface and in all trophoblast subtypes except in primary trophoblast giant cells. Plac1 knockdown retarded the progress of TS differentiation, indicating that Plac1 is necessary for normal trophoblast differentiation into various trophoblast subpopulations.
Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration
Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus.
Plac1 is a paternally imprinted, X-linked gene essential for normal placental and embryonic development.
May play a role in placental development (By similarity).
cancer/testis antigen 92
, placenta-specific protein 1
, placenta-specific 1
, ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 26