Plastin 3 Proteins (PLS3)

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Additionally we are shipping Plastin 3 Antibodies (79) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLS3 5358 P13797
PLS3 81748  
PLS3 102866 Q99K51
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Top Plastin 3 Proteins at antibodies-online.com

Showing 8 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
$730.00
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Escherichia coli (E. coli) Mouse His tag 100 μg 15 to 18 Days
$768.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Escherichia coli (E. coli) Human His tag 100 μg 14 to 16 Days
$505.35
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg 60 to 71 Days
$3,822.50
Details

PLS3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Plastin 3 (PLS3) Interaction Partners

Human Plastin 3 (PLS3) interaction partners

  1. study identifies PLS3 as a potential target for enhancing the p38 MAPK-mediated apoptosis induced by paclitaxel.

  2. PLS3 mutation is associated with X-linked osteoporosis.

  3. Regulation of osteoclastogenesis and bone remodeling via the PLS3-NKRF-NFkappaB-NFATC1 axis unveils a novel possibility to counteract osteoporosis.

  4. PLS3 deletions lead to severe childhood-onset osteoporosis resulting from defective bone matrix mineralization.

  5. PLS3 sequencing in childhood-onset primary osteoporosis identifies two novel disease-causing variants.

  6. T-plastin mediates the hypoxia-induced membrane trafficking

  7. PLS3 mutation plays a role in low turnover osteoporosis pathophysiology.

  8. In this study, the authors found that the actin filament bundling abilities of PLS1 and PLS2 were similarly sensitive to Ca(2+) (pCa50 ~6.4), whereas PLS3 was less sensitive (pCa50 ~5.9).

  9. Patients with PLS3 mutation-related osteoporosis respond to teriparatide treatment.

  10. We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype

  11. PLS3 expression does not always modify SMA phenotype

  12. findings emphasize the power of genetic modifiers, PLS3 and CORO1C, to unravel the cellular pathomechanisms underlying spinal muscular atrophy (SMA)--and the power of combinatorial therapy based on splice correction of SMN2 and endocytosis improvement to efficiently treat SMA

  13. t is beyond doubt that PL S3 must be further investigated to determine its role in diagnostics, prediction, treatment and monitoring of treatment of colorectal cancer.

  14. PLS3 is a genuine spinal muscular atrophy protective modifier in SMN1-deleted individuals

  15. Measurements of SMN and PLS3 transcript and protein levels in induced pluripotent stem cell-derived motor neurons show limited value as Spinal muscular atrophy biomarkers.

  16. High levels of recombinant hPLS3 mRNA were expressed in motor neurons of SMA mice and an increased level of PLS3 protein in total spinal cord, yet neither survival nor the fundamental electrophysiological aspects of the neuromuscular junction improved.

  17. results confirm the role of PLS3 mutations in early onset osteoporosis. The mechanism whereby PLS3 affects bone health is unclear, but it may be linked to osteocyte dendrite function and skeletal mechanosensing

  18. plastin 3 is a regulator of actin microfilament bundles at the ES in which it dictates the configuration of the filamentous actin network

  19. PLS3 was expressed in circulating tumor cells undergoing the epithelial-mesenchymal transition in patients with breast cancer; an excellent biomarker for identifying groups at risk of recurrence or with a poor prognosis

  20. PLS3 overexpression is associated with colorectal cancer.

Mouse (Murine) Plastin 3 (PLS3) interaction partners

  1. Regulation of osteoclastogenesis and bone remodeling via the PLS3-NKRF-NFkappaB-NFATC1 axis unveils a novel possibility to counteract osteoporosis.

  2. Of the six biomarkers, only COMP and DPP4 showed high and SPP1 moderate correlation with the spinal muscular atrophy phenotype. PLS3 overexpression neither influenced the SMN level nor the six biomarkers, supporting the hypothesis that PLS3 acts as an independent protective modifier.

  3. Data indicate there are 6 mutations in Plastin-3 (PLS3) responsible for X-linked osteoporosis, and the mutation c.759_760insAAT (p.Ala253_Leu254insAsn) is located in exon 8.

  4. Depletion of Pls3 transcripts in mouse embryos caused basement membrane and polarity defects in the epidermis which were secondary to the disruption of the basement membrane but had little effect on cell adhesion and differentiation.

Zebrafish Plastin 3 (PLS3) interaction partners

  1. decreased PLS3 contributes to spinal muscular atrophy motor phenotypes

Plastin 3 (PLS3) Protein Profile

Protein Summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Plastin 3 Proteins (PLS3)

  • plastin 3 (PLS3)
  • plastin 3 (Pls3)
  • plastin 3 (T-isoform) (Pls3)
  • plastin 3 L homeolog (pls3.L)
  • plastin 3 (pls3)
  • plastin 3 (T isoform) (pls3)
  • AI115446 protein
  • AL024105 protein
  • DKFZp459D0939 protein
  • MGC68681 protein
  • MGC106020 protein
  • Plastin-3 protein
  • PLS3 protein
  • T-fimbrin protein
  • t-plastin protein
  • wu:fc04g03 protein
  • zgc:91903 protein

Protein level used designations for Plastin 3 Proteins (PLS3)

T fimbrin , T plastin , plastin-3 , T-plastin , plastin 3 (T-isoform) , plastin 3, T , plastin 3 , plastin 3 (T isoform) , plastin-3-like , LOW QUALITY PROTEIN: plastin-3

GENE ID SPECIES
5358 Homo sapiens
81748 Rattus norvegicus
102866 Mus musculus
399002 Xenopus laevis
505687 Bos taurus
595091 Xenopus (Silurana) tropicalis
465817 Pan troglodytes
481025 Canis lupus familiaris
709055 Macaca mulatta
100053927 Equus caballus
100158187 Sus scrofa
100172754 Pongo abelii
100403677 Callithrix jacchus
100475279 Ailuropoda melanoleuca
100545275 Meleagris gallopavo
100602943 Nomascus leucogenys
100689375 Cricetulus griseus
100718763 Cavia porcellus
436598 Danio rerio
Selected quality suppliers for Plastin 3 Proteins (PLS3)
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