Poly(rC) Binding Protein 1 (PCBP1) ELISA Kits

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. Additionally we are shipping PCBP1 Antibodies (127) and PCBP1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PCBP1 5093 Q15365
PCBP1 23983 P60335
Anti-Rat PCBP1 PCBP1 500242  
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Top PCBP1 ELISA Kits at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Mouse < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Cow
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details
Please inquire
  10 reactions Log in to see 4 to 6 Days
$549.00
Details

More ELISA Kits for PCBP1 Interaction Partners

Human Poly(rC) Binding Protein 1 (PCBP1) interaction partners

  1. Knockdown of PCBP1 promoted both tumorigenesis and metastatic progression in prostate cancer, suggestive of PCBP1 functioning as a tumor suppressor in normal prostate epithelial cells and potentiates tumor formation by up-regulation of MAPK1 (show MAPK3 ELISA Kits) expression.

  2. PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions. PCBP1 does not bind to such oligoribonucleotides but instead binds firmly to oligoribonucleotides in which two 8-oxoG residues are located nearby. The structure-function relationship of PCBP1 was established with the use of PCBP1 mutant proteins with defective conserved KH domains. PCBP1 operates when RNA is more severely damaged.

  3. High HNRPE1 expression is associated with pancreatic cancer metastasis.

  4. UBE4A targets PCBP1 for proteasomal degradation and that UBE4A expression can serve as a novel biomarker in thyroid cancer patients.

  5. Study report a novel interaction between mutant HSPB1 (show HSPB1 ELISA Kits)-P182L and the RNA binding protein (show PTBP1 ELISA Kits) PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (show HSPB1 ELISA Kits) in neurodegenerative diseases.

  6. It is reported here that TGF-beta (show TGFB1 ELISA Kits) directly regulates alternative splicing of cancer stem cell marker CD44 (show CD44 ELISA Kits) through a phosphorylated threonine179 of SMAD3 (show SMAD3 ELISA Kits)-mediated interaction with RNA-binding protein (show PTBP1 ELISA Kits) PCBP1.

  7. our findings suggest that PCBP1 is a molecular marker of oxaliplatin resistance in colorectal cancer

  8. Data suggest a 216-nucleotide proximal cis-element in LIF (show LIF ELISA Kits) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (show NCL ELISA Kits) and PCBP1, 2 trans-acting factors that bind to and stabilize LIF (show LIF ELISA Kits) mRNA. [LIF (show LIF ELISA Kits) = leukemia inhibitory factor (show LIF ELISA Kits); PCBP1 = poly(rC) binding protein 1]

  9. It was concluded that a novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells.

  10. TGF-beta (show TGFB1 ELISA Kits) signaling through Akt2 (show AKT2 ELISA Kits) induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1), driving epithelial to mesenchymal transition and metastasis.

Mouse (Murine) Poly(rC) Binding Protein 1 (PCBP1) interaction partners

  1. Study report a novel interaction between mutant HSPB1 (show HSPB1 ELISA Kits)-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (show HSPB1 ELISA Kits) in neurodegenerative diseases.

  2. These studies demonstrate the importance of ferritin (show FTL ELISA Kits) for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin (show FTL ELISA Kits).

  3. Pcbp1 modulated the processing of muscle-enriched miR-1, miR (show MLXIP ELISA Kits)-133, and miR (show MLXIP ELISA Kits)-206 by physically interacting with argonaute 2 (AGO2 (show EIF2C2 ELISA Kits)) and other miRNA pathway components.

  4. These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.

  5. PCBP1 may serve as a novel maternal factor.

  6. Our analysis of PCBP1 and PCBP2 expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.

  7. knockdown of PCBP1 led to a reversal effect on the transcriptional inactivation during oocyte growth, which highlights the important role of PCBP1 in maintaining the gobal transcriptional silencing when the growth phase is completed

  8. TGF-beta (show TGFB1 ELISA Kits) modulates the expression of Dab2 (show DAB2 ELISA Kits) and ILEI (show FAM3C ELISA Kits) mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT element in the 3'UTR (show UTS2R ELISA Kits) of Dab2 (show DAB2 ELISA Kits) and ILEI (show FAM3C ELISA Kits).

  9. To define the mechanism of STAT3C suppression of transcript. and/or translational activity of NF-kappaB we found that a alphaCP-1 interacted with STAT3C. alphaCP-1 is a K-homol. domain-containing RNA-binding prot with specific for C-rich pyrimidine tracts

PCBP1 Antigen Profile

Antigen Summary

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Gene names and symbols associated with PCBP1

  • poly(rC) binding protein 1 (PCBP1) antibody
  • poly(rC) binding protein 1 L homeolog (pcbp1.L) antibody
  • poly(rC)-binding protein 1 (LOC100388387) antibody
  • poly(rC) binding protein 1 (Pcbp1) antibody
  • alphaCP-1 antibody
  • hnRNP-E1 antibody
  • hnRNP-X antibody
  • hnRNP E1 antibody
  • HNRPE1 antibody
  • HNRPX antibody
  • PCBP1 antibody
  • RGD1561319 antibody
  • WBP17 antibody
  • [a]CP-1 antibody

Protein level used designations for PCBP1

poly(rC) binding protein 1 , poly(rC)-binding protein 1-like , alpha-CP1 , heterogeneous nuclear ribonucleoprotein E1 , heterogenous nuclear ribonucleoprotein E1 , heterogenous nuclear ribonucleoprotein X , nucleic acid-binding protein SUB2.3 , poly(rC)-binding protein 1 , hnRNP-E1 protein , hnRNP E1 , hnRNP-E1

GENE ID SPECIES
459300 Pan troglodytes
100037147 Xenopus laevis
100388387 Callithrix jacchus
100459720 Pongo abelii
5093 Homo sapiens
509917 Bos taurus
100008848 Oryctolagus cuniculus
23983 Mus musculus
500242 Rattus norvegicus
481417 Canis lupus familiaris
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