Polybromo 1 Proteins (PBRM1)

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. Additionally we are shipping Polybromo 1 Antibodies (40) and Polybromo 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PBRM1 55193 Q86U86
PBRM1 66923  
Rat PBRM1 PBRM1 306254  
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Top Polybromo 1 Proteins at antibodies-online.com

Showing 4 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
$880.00
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant PBRM1 (464-605) activity using AlphaScreen. PBRM1 (464-605) was used in an AlphaScreen® assay to generate a titration curve demonstrating the signal response in the presence of modified peptide substrate at increasing protein concentrations. This data was generated and kindly provided courtesy of ChemPartner. Recombinant PBRM1 (464-605) protein gel. PBRM1 (464-605) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg 1 to 2 Days
$472.50
Details

PBRM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, , ,
Mouse (Murine)

More Proteins for Polybromo 1 (PBRM1) Interaction Partners

Human Polybromo 1 (PBRM1) interaction partners

  1. The biochemical and mutational analyses have identified bromodomain, BD4 as being critically important for maintaining proper PBRM1 function and demonstrate that BD4 mutations increase clear cell renal cell carcinoma cell growth.

  2. Decreased expression of PBRM1 is correlated with poor prognosis and advanced clinicopathological features in patients with renal cell carcinoma (RCC).

  3. we show a strong relationship between the expression profiles of PBRM1, BAP1 and SETD2 in ccRCC suggesting reciprocal synergy effects in the context of tumor suppression.

  4. In intrahepatic cholangiocarcinoma retained expression of BAP-1 and PBRM-1, and an overexpression of S100P are related to a poor prognosis.

  5. Mechanisms of resistance to rapamycin analogs in renal cell carcinoma remain unclear and study results suggest that PBRM1 loss may contribute to sensitivity through complex transcriptional effects.

  6. Low PBRM1 expression is associated with early stages of clear cell renal cell carcinoma.

  7. Study suggests that reduced expression of PBRM1 and VHL in clear cell renal cell carcinoma is correlated with an increased tumor aggressiveness.

  8. These findings indicate that PBRM1 mutation (and resultant loss of expression) is a late event during biliary carcinogenesis

  9. Clear-cell renal carcinoma cell lines whose ability to proliferate in vitro and in vivo is sensitive to wild-type BAF180, but not a tumor-associated BAF180 mutant, showed that the growth suppression by BAF180 is linked to its ability to form a canonical PBAF complex containing BRG1 that dampens the HIF transcriptional signature.

  10. Knockdown of PBRM1 in colon cancer cells increased the expression of two receptor genes (RIG-I and MDA5) and upregulated interferon (IFN)-related and inflammation-related gene signatures. Lower PBRM1 expression was associated with advanced pathological grade and poorer survival of colorectal cancer (CRC) patients, indicating that PBRM1 could serve as a potential prognostic biomarker for CRC.

  11. kidney-specific deletion of Vhl and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.

  12. PBRM1 mutation is associated with small Cell Lung Cancer.

  13. These findings indicate that PBRM1 alters cell cycle progression and inhibits proliferation and migration of renal cell carcinoma ACHN cells through the chemokine/chemokine receptor pathway.

  14. our integrative analysis suggested that methylation and miRNA alterations were likely the downstream events associated with PBRM1 truncation mutations. In summary, this study provided some important insights into the understanding of tumorigenesis driven by PBRM1 truncated mutations in Clear cell renal cell carcinoma (ccRCC). The approach may be applied to many driver genes in various cancers.

  15. BAP1 and PBRM1 loss is seen frequently in intrahepatic cholangiocarcinoma

  16. PBRM1 gene deletion is associated with chordoma.

  17. conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation

  18. Synthetic lethality screening identifies TIP60-dependent radiation sensitivity in the absence of BAF180.

  19. Functionally, suppression of PBRM1 expression promoted cell proliferation and cell cycle progression

  20. PBRM1 re-expression led to upregulation of genes involved in cellular adhesion, carbohydrate metabolism, apoptotic process and response to hypoxia, and a downregulation of genes involved in different stages of cell division.

Mouse (Murine) Polybromo 1 (PBRM1) interaction partners

  1. Data show that 100% of von Hippel-Lindau tumor suppressor protein (Vhl) / polybromo 1 protein (Pbrm1) knockout mice developed renal cancers by 20 months of age.

  2. We conditionally targeted Bap1 and Pbrm1 (with Vhl) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (ccRCC)origins

  3. dual inactivation of Vhl with either Bap1 or Pbrm1 results in faithful genetically engineered murine models of clear cell renal cell carcinoma (ccRCC).

  4. Data suggest BAF180 protein as a critical regulator of cellular senescence and HSC homeostasis, which is at least partially regulated through BAF180-mediated suppression of cell cycle regulator p21 expression.

  5. kidney-specific deletion of Vhl and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.

  6. Data demonstrate a function for BAF180 in promoting genome stability that is distinct from its well-characterized role in transcriptional regulation.

  7. BAF180 is a repressor of IL-10 transcription in Th2 cells and suggest that the differential recruitment of different SWI/SNF subtypes can have direct consequences on chromatin structure and gene transcription.

  8. BAF180 is critical for coronary vessel formation.

Polybromo 1 (PBRM1) Protein Profile

Protein Summary

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

Gene names and symbols associated with Polybromo 1 Proteins (PBRM1)

  • polybromo 1 (PBRM1)
  • polybromo 1 L homeolog (pbrm1.L)
  • protein polybromo-1 (LOC100170602)
  • polybromo 1 (pbrm1)
  • polybromo 1 (Pbrm1)
  • 2610016F04Rik protein
  • AI507524 protein
  • BAF180 protein
  • Pb1 protein
  • RGD1565549 protein

Protein level used designations for Polybromo 1 Proteins (PBRM1)

polybromo 1 , protein polybromo-1 , BRG1-associated factor 180 , polybromo-1D , glutamate receptor interacting protein 2 , polybromo 1 protein , 2310032M22Rik

GENE ID SPECIES
460430 Pan troglodytes
495429 Xenopus laevis
100170602 Xenopus (Silurana) tropicalis
55193 Homo sapiens
565366 Danio rerio
396074 Gallus gallus
476593 Canis lupus familiaris
506557 Bos taurus
66923 Mus musculus
306254 Rattus norvegicus
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