Polymeric Immunoglobulin Receptor (PIGR) ELISA Kits

Rhesus Monkey Polymeric Immunoglobulin Receptor (PIGR) interaction partners

1. Both pIgR and FcRn mRNA levels were significantly reduced in the duodenal mucosa during acute SHIV infection and in the jejunum and caecum during chronic SHIV/SIV infection.

Human Polymeric Immunoglobulin Receptor (PIGR) interaction partners

1. We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients.

2. pIgR may be involved in pancreatic ductal adenocarcinoma progression and may be linked stromal activity. Further work on its precise role is mandated in in vivo models, to understand its influence on cancer progression.

3. RrgA, binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR

4. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.

5. The polymeric immunoglobulin receptor secretory component structure comprises five immunoglobulin-like domains (D1-D5) arranged as a triangle, with an interface between ligand-binding domains D1 and D5.

6. Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis.

7. Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa.

8. These results demonstrate that SLPI down-regulates pIgR expression through the NF-kappaB signaling pathway by inhibiting degradation of IkappaBbeta protein.

9. Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases.

10. the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 pathway activation.

11. Positive expression of pIgR was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis.

12. In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway.

13. Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma.

14. High PIGR expression independently predicts a decreased risk of recurrence and an improved survival in patients with adenocarcinoma of the upper gastrointestinal tract

15. pIgR down-regulation in chronic obstructive pulmonary disease correlates with severity. Bronchial epithelium in vitro retains aberrant imprinting for pIgR expression. pIgR down-regulation is linked to TGF-beta-driven reprogramming of bronchial epithelium.

16. Results indicated that the polymeric immunoglobulin receptor (pIgR) can be divided into several functionally distinct regions.

17. Polymeric immunoglobulin receptor (PIGR)expression was lost in most lung cancers and pre-invasive bronchial lesions, suggesting that PIGR downregulation is an early event in lung tumourigenesis. PIGR overexpression inhibited cell proliferation.

18. The comparison of nonsmokers, smokers, and smokers with moderate COPD revealed 15 changed proteins with the majority, including polymeric immunoglobulin receptor (PIGR), being elevated in smokers and subjects with COPD.

19. Both native and phage-bound variable domain of camelid derived heavy chain only antibodies, were only able to get across polarized MDCK cells that express the human pIgR gene in a basolateral to apical fashion.

20. Results identify pIgR as a potential link between hepatitis B virus-derived hepatitis and HCC metastasis and provide evidence in support of pIgR as a prognostic biomarker for HCC and a potential therapeutic target.

Cow (Bovine) Polymeric Immunoglobulin Receptor (PIGR) interaction partners

1. This study evaluated the production of polymeric immunoglobulin receptor and immunoglobulin A in the salivary glands of cattle.

Mouse (Murine) Polymeric Immunoglobulin Receptor (PIGR) interaction partners

1. RrgA, binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR

2. pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.

3. Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.

4. the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 pathway activation.

5. In a mouse intestinal explant model, the heat-inactivated potential probiotic BB6378 increases intestinal pIgR expression in a site-specific manner on the epithelium via MyD88.

6. pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.

7. Results reveal a novel Yes-EGFR-ERK-FIP5 signalling network for regulation of pIgA-pIgR transcytosis.

8. Blockade of transepithelial transport of dimeric IgA in pIgR knockout mice reduces the degree of protection or cross-protection against viral infection, in parallel with a marked increase in serum IgA concentration and decrease in nasal IgA concentration.

9. Mice deficient in SIgA have been generated by knocking out the pIgR and assessing their ability to maintain normal mucosal homeostasis and to induce mucosal and systemic immune responses against pathogenic and nonpathogenic stimuli.

10. Mice that lack expression of the polymeric immunoglobulin receptor have approximately 5-fold more systemic IgA and 6-fold less nasal IgA antibodies than wild-type mice due to defective IgA transport into mucosal tissues.

11. Data suggest that the pIgR and/or the secretory component are important for the maintenance of epithelial integrity and mucosal homeostasis in the colonic epithelium.

12. pIgR is essential in intestinal defense against pathogenic microbes with high-level and persistent luminal presence.

13. Novel localization of pIgR to the regulated secretory pathway of lacrimal gland acinar cells and its secretion therefrom may be affected by its novel interaction with Rab3D.

14. The poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract.