anti-Potassium Channel, Subfamily K, Member 5 (KCNK5) Antibodies

Human Potassium Channel, Subfamily K, Member 5 (KCNK5) interaction partners

1. mutations in the promoter region of the TWIK-related acid-sensitive K(+) channel 2 (TASK-2) gene did not result in hypertension or primary aldosteronism (PA) during long-term follow-up in healthy participants thus they do not seem to be a factor in causing PA by themselves.

2. As a novel finding, our study suggests a role for KCNK5 in the regulation of platelet size and maturity. Furthermore, our findings confirm an association between the SH2B3 (show SH2B3 Antibodies)-locus and platelet count.

3. In human aldosterone-producing adrenocortical cancer cell lines, roxithromycin inhibited KCNJ5MUT-induced induction of CYP11B2 (show CYP11B2 Antibodies) (encoding aldosterone synthase (show CYP11B2 Antibodies)) expression and aldosterone production.

4. HLA-DQB1 (show HLA-DQB1 Antibodies)*06:02 does not seem to be associated with hypoxic ventilatory response or hypercapnic ventilatory response; however there are point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and hypercapnic ventilatory response

5. These results therefore provide further structural and functional insights into the possible pathophysiological effects of this missense variant in TASK-2.

6. Results show that up-regulated KCNK5 in activated human T cells does not play a volume regulatory role, due to decreased Cl- permeability suggesting that the KCNK5 upregulation might play a role in hyperpolarization of the cell membrane leading to increased Ca2 (show CA2 Antibodies)+ influx and proliferation of T cells.

7. Potassium channel (show KCNAB2 Antibodies) TASK2 drives human NK-cell proliferation and cytolytic function.

8. Mutant genes (CELA1 (show CELA1 Antibodies), HSPG2 (show HSPG2 Antibodies), and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis.

9. The TASK-2 channel lower expression represents a hallmark of aldosterone-producing adenoma causing aldosteronism and is associated with a higher expression of hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-23 and hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-34.

10. Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells

Mouse (Murine) Potassium Channel, Subfamily K, Member 5 (KCNK5) interaction partners

1. The apparent affinity of TASK-2 for membrane PI(4,5)P2 is low and it is conceivable that changing competition by intracellular polycationic compounds might mediate the previously reported sensitivity of TASK-2 to changes in cell volume. A decrease in PI(4,5)P2 by activation of Gq-PCRs is also probably responsible for TASK-2 inhibition.

2. KCNK5 channels are indispensable for the maintenance of hearing. KCNK5 is mainly found in outer sulcus Claudius', Boettcher's and root cells.

3. The data identify GPR4 (show GPR4 Antibodies) and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.

4. TASK-2 is upregulated under hypoxia in a HIF-1alpha (show HIF1A Antibodies)-dependent manner in B cells.

5. The strong physiological impairment of KCNK5 in Ehrlich cells after long-term hypotonic stimulation is predominantly due to down-regulation of the KCNK5 protein synthesis.

6. data are compatible with the concept that TASK-2 channels are modulated by Gbetagamma subunits of heterotrimeric G protein; propose that this modulation is a novel way in which TASK-2 can be tuned to its physiological functions

7. alkaline-activated TASK-2 channels contribute to pH sensitivity in retrotrapezoid nucleus neurons

8. Kv1.3 (show KCNA3 Antibodies)/TASK2 channels appear to be mainly responsible for regulatory volume decrease in murine T-lymphocytes.

9. a cycle of protonation/deprotonation of pH(o)-sensing arginine 224 side chain gates the TASK-2 channel by electrostatically tuning the conformational stability of its selectivity filter.

10. The authors report for the first time the expression of TASK-2 in B cells and surmise that the upregulation of TASK-2 by B cell receptor ligation is associated with the apoptosis of immature B cells.