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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.
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Human Polyclonal KCTD10 Primary Antibody for ICC, IF - ABIN4328504
Kubota, Yoshida, Tsuda, Suehara, Okubo, Saito, Orita, Sato, Taguchi, Yao, Kaneko, Katai, Kawai, Kondo: Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor. in PLoS ONE 2013
Our studies suggest that KCTD10 plays crucial roles in embryonic angiogenesis and heart development in mammalians by negatively regulating the Notch (show NOTCH1 Antibodies) signaling pathway.
These findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of coronary heart disease by altering plasma HDL-C levels in Han Chinese.
The gastrointestinal stromal tumor-specific transcription factor ETV1 (show ETV1 Antibodies) may have no prognostic potential, whereas its downstream gene KCTD10 is associated with a favorable prognosis.
KCTD10 inhibited the transcriptional activities of nuclear factor kappa B (NF-kappaB (show NFKB1 Antibodies)) and activating protein-1 reporters
KCTD10 may be associated with DNA synthesis and cell proliferation
binding of SP1 (show PSG1 Antibodies) to the proximal promoter region stimulated the promoter activity and endogenous KCTD10 expression, whereas binding of AP-2alpha (show TFAP2A Antibodies) to this region showed opposite effects.
For the SNPs KCTD10_i5642G-->C and MVK_S52NG-->A, homozygotes for the major alleles (G) had lower HDL (show HSD11B1 Antibodies)-cholesterol concentrations than did carriers of the minor alleles (P = 0.005 and P = 0.019, respectively).
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).
potassium channel tetramerisation domain containing 10
, BTB/POZ domain-containing protein KCTD10
, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
, potassium channel tetramerization domain-containing 10
, potassium channel tetramerization domain-containing protein 10