anti-Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) Antibodies

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Additionally we are shipping KCNMB1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNMB1 16533 Q8CAE3
KCNMB1 3779 Q16558
KCNMB1 29747 P97678
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Top anti-KCNMB1 Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: A431 , B: H1299 12% SDS PAGE antibody diluted at 1:1000 WB Image Sample (50 ug of whole cell lysate) A: mouse heart 12% SDS PAGE antibody diluted at 1:10000 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNMB1 Antibody (Center) in A549 cell line lysates (35ug/lane). This demonstrates the KCNMB1 antibody detected the KCNMB1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of KCNMB1 using COS7 whole cell lysates ABIN6279215 staining HepG2? cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western blot analysis in A549 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of various cells, using KCNMB1 antibody. Western blot analysis of extracts of various cell lines, using KCNMB1 antibody (ABIN4904137) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry (IHC) analyzes of MaxiKbeta antibody in paraffin-embedded human brain tissue. 0.1 mg 6 to 8 Days
$434.50
Details
Human Rabbit Un-conjugated ELISA, WB 200 μL 12 to 14 Days
$438.90
Details
Chimpanzee Rabbit Un-conjugated IF, WB   100 μg 11 to 14 Days
$669.17
Details
Human Rabbit Un-conjugated IHC, WB   100 μL 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 16 Days
$658.43
Details

Top referenced anti-KCNMB1 Antibodies

  1. Human Polyclonal KCNMB1 Primary Antibody for WB - ABIN443352 : Pethő, Tanner, Tajhya, Huq, Laragione, Panyi, Gulko, Beeton: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. in Arthritis research & therapy 2016 (PubMed)

More Antibodies against KCNMB1 Interaction Partners

Mouse (Murine) Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) interaction partners

  1. Compromised PASMC beta1 function may contribute to the heightened microvascular vasoconstriction that characterizes pulmonary hypertension.

  2. Whole-cell currents density of BK channels and amplitude of spontaneous transient outward currents were significantly reduced in hypoxia vascular myocytes.

  3. Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2.

  4. Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling.

  5. 7-Ketocholesterol induces the reduction of KCNMB1 through the AhR pathway.

  6. BK channel activity directly affects vascular tone but influences blood pressure independent of this effect via different pathways

  7. up-regulation of NF-kappaB-dependent MuRF1 expression is a novel mechanism that leads to BK channelopathy and vasculopathy in diabetes

  8. Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa channel remodeling, which contributes to vasoconstriction during diabetes mellitus.

  9. The activity of BKbeta1 is higher in cerebral smooth muscle cells compared to pulmonary artery.

  10. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently.

  11. In the absence of nitric oxide and prostacyclin 11,12-EET contributes to pulmonary vasoconstriction by stimulating the association of the potassium large conductance calcium-activated channel subunits alpha and beta (1) of mitochondrial BK channels.

  12. BK channels play a prominent role in smooth muscle function only in the distal colon of mice. Defects in smooth muscle BK channel function disrupt colonic motility causing constipation.

  13. Impaired sodium excretion resulting form loss of normal purinergic regulation of ENaC in BK-beta4 null mice likely contributes to their elevated blood pressure

  14. Vascular smooth muscle cell cholesterol and BK beta1 are both required for ethanol inhibition of BK and resulting cerebral artery constriction, with health-related implications for manipulating cholesterol levels in alcohol-induced cerebrovascular disease.

  15. these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.

  16. Reduced vascular BK channel function does not protect against hypotension in the early stage of septic shock; in the later stage, smooth muscle BK channel deficiency enhances organ damage and mortality

  17. BKbeta4 and to a lesser degree BKbeta1 transcripts and protein are detected in several astrocytic populations and cultured cells.

  18. enhanced tracheal contraction of the BK beta1 knockout can be ascribed to a defect in BK channel opposition of M2 receptor-mediated contractions

  19. The results indicate that BK beta1-KO mice are not hypertensive on normal or high-salt intake

  20. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype.

Human Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) interaction partners

  1. Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling.

  2. These results provide further insights into the mechanism of modulation of the different N-terminal regions of the BKCa channel by beta-subunits.

  3. By introducing lanthanide binding tags in the extracellular region of the alpha- or beta1-subunit, we determined (i) a basic extracellular map of the BK channel, (ii) beta1-subunit-induced rearrangements of the voltage sensor in alpha-subunits, and (iii) the relative position of the beta1-subunit within the alpha/beta1-subunit complex.

  4. The study demonstrates that both transmembrane domains of BKbeta1 are required to provide the characteristic ion current phenotype of beta1-containing BK channels.

  5. Data show that two lysine residues that are unique to the N terminus of calcium-activated potassium channel subunit beta-1 were identified to be sufficient for voltage-sensor modulation.

  6. To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone. Blood of atherosclerotic patients shows increased concentration of 7-ketocholesterol, possibly a harmful lipid to blood vessels.

  7. Bisphenol A activates BK alpha via an extracellular site and that Bisphenol A-sensitivity is increased by the beta1 subunit.

  8. N-terminal isoforms of the large-conductance Ca(2)-activated K channel are differentially modulated by the auxiliary beta1-subunit.

  9. In large-conductance calcium-dependent potassium channels, beta1 and beta2 subunits alter the voltage sensing domain-cytosolic domain interface.

  10. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently.

  11. HIF-1alpha increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter

  12. Cloned BK(Ca) channel directly regulated apoptosis and proliferation of HEK293 cell under hyperglycemia condition.

  13. Here we found that KCNMB1 common variant Glu65Lys influences glomerular filtration rate across multiple populations of different clinical characteristics and biogeographic ancestries.

  14. downregulation of vascular BK-beta(1) expression in diabetes and in high-glucose culture conditions was associated with FOXO-3a/FBXO-dependent increase in BK-beta(1) degradation.

  15. In transfected HEK293 cells, activation of cloned BK(Ca) channel induced apoptosis, whereas inhibition of cloned BK(Ca) channel decreased apoptosis.

  16. The expressed hSloalpha + beta1 subunit complex demonstrated to be fully functional for its typical single-channel traces, Ca(2+)-sensitivity, voltage-dependency, high conductance (151 +/- 7 pS), and its pharmacological activation and inhibition.

  17. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype.

  18. Phosphorylation-dependent functional coupling of hSlo and its hbeta 4 subunit

  19. have a reset baroreflex. Variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function.

  20. pore-forming alpha subunit of the hSlo channel promotes N-linked glycosylation of its auxiliary beta4 subunit, and this in turn influences the modulation of the channel by the beta4 subunit

Pig (Porcine) Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) interaction partners

  1. The study verified that the BK(Ca) channel alpha-subunit is located to smooth muscle cells of porcine basilar and middle cerebral arteries.

KCNMB1 Antigen Profile

Protein Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.

Gene names and symbols associated with KCNMB1

  • potassium calcium-activated channel subfamily M regulatory beta subunit 1 (KCNMB1) antibody
  • potassium large conductance calcium-activated channel, subfamily M, beta member 1 (Kcnmb1) antibody
  • potassium calcium-activated channel subfamily M regulatory beta subunit 1 (Kcnmb1) antibody
  • BKBETA antibody
  • BKbeta1 antibody
  • hbeta1 antibody
  • hslo-beta antibody
  • K(VCA)beta antibody
  • k(VCA)beta-1 antibody
  • KCNMB1 antibody
  • SLO-BETA antibody
  • slo-beta-1 antibody

Protein level used designations for KCNMB1

calcium-activated potassium channel subunit beta-1 , calcium-activated potassium channel beta subunit , potassium large conductance calcium-activated channel, subfamily M, beta member 1 , BK channel beta subunit , BK channel subunit beta-1 , BKbeta , calcium-activated potassium channel subunit beta , calcium-activated potassium channel, subfamily M subunit beta-1 , charybdotoxin receptor subunit beta-1 , k(VCA)beta-1 , maxi K channel subunit beta-1 , slo-beta , slo-beta-1 , large conductance Ca2+-activated K+ channel beta 1 subunit , BKbeta1 , slowpoke-beta , calcium activated potassium channel beta subunit , calcium activated potassium channel beta subunit protein , calcium dependent potassium channel beta subunit protein , large conductance Ca2+-activated K+ channel beta1 subunit , large conductance calcium-activated potassium channel beta subunit , large conductance calcium-activated potassium channel beta1 subunit , maxi-K channel beta subunit

GENE ID SPECIES
395301 Gallus gallus
462258 Pan troglodytes
16533 Mus musculus
3779 Homo sapiens
29747 Rattus norvegicus
407176 Bos taurus
403983 Canis lupus familiaris
100009034 Oryctolagus cuniculus
100271876 Sus scrofa
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