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MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Additionally we are shipping KCNMB1 Proteins (5) and many more products for this protein.
Showing 10 out of 51 products:
Human Polyclonal KCNMB1 Primary Antibody for WB - ABIN443352
Pethő, Tanner, Tajhya, Huq, Laragione, Panyi, Gulko, Beeton: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. in Arthritis research & therapy 2016
Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2 (show CA2 Antibodies)+) channels, leading to Ca(2 (show CA2 Antibodies)+) influx and the activation of Rho kinase (ROCK) 1 (show ROCK1 Antibodies) and 2.
Expression of vascular large-conductance calcium-activated potassium channel (show KCNAB2 Antibodies) Kcnmb1 is regulated by Nrf2 (show NFE2L2 Antibodies) signaling.
7-Ketocholesterol induces the reduction of KCNMB1 through the AhR pathway.
BK channel (show KCNMA1 Antibodies) activity directly affects vascular tone but influences blood pressure independent of this effect via different pathways
up-regulation of NF-kappaB (show NFKB1 Antibodies)-dependent MuRF1 (show TRIM63 Antibodies) expression is a novel mechanism that leads to BK channelopathy and vasculopathy in diabetes
Our results support a model whereby subcellular anchoring of CaN by AKAP150 (show AKAP5 Antibodies) is a key molecular determinant of vascular BKCa (show KCNMA1 Antibodies) channel remodeling, which contributes to vasoconstriction during diabetes mellitus.
The activity of BKbeta1 is higher in cerebral smooth muscle cells compared to pulmonary artery.
BK channels play a prominent role in smooth muscle function only in the distal colon of mice. Defects in smooth muscle BK channel (show KCNMA1 Antibodies) function disrupt colonic motility causing constipation.
Impaired sodium excretion resulting form loss of normal purinergic regulation of ENaC (show SCNN1A Antibodies) in BK-beta4 null mice likely contributes to their elevated blood pressure
these results suggested that oxidative stress inhibited Akt (show AKT1 Antibodies) signaling and facilitated the FOXO (show FOXO3 Antibodies)-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.
Expression of vascular large-conductance calcium-activated potassium channel (show KCNAB2 Antibodies) Kcnmb1 is regulated by Nrf2 (show GABPA Antibodies) signaling.
These results provide further insights into the mechanism of modulation of the different N-terminal regions of the BKCa (show KCNMA1 Antibodies) channel by beta-subunits.
By introducing lanthanide binding tags in the extracellular region of the alpha- or beta1-subunit, we determined (i) a basic extracellular map of the BK channel (show KCNMA1 Antibodies), (ii) beta1-subunit-induced rearrangements of the voltage sensor in alpha-subunits, and (iii) the relative position of the beta1-subunit within the alpha/beta1-subunit complex.
The study demonstrates that both transmembrane domains of BKbeta1 are required to provide the characteristic ion current phenotype of beta1-containing BK channels.
Data show that two lysine residues that are unique to the N terminus of calcium-activated potassium channel subunit beta-1 were identified to be sufficient for voltage-sensor modulation.
To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone. Blood of atherosclerotic patients shows increased concentration of 7-ketocholesterol, possibly a harmful lipid to blood vessels.
N-terminal isoforms of the large-conductance Ca(2 (show CA2 Antibodies))-activated K channel (show KCNC4 Antibodies) are differentially modulated by the auxiliary beta1-subunit.
HIF-1alpha (show HIF1A Antibodies) increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter
Here we found that KCNMB1 common variant Glu65Lys influences glomerular filtration rate across multiple populations of different clinical characteristics and biogeographic ancestries.
downregulation of vascular BK-beta(1) expression in diabetes and in high-glucose culture conditions was associated with FOXO (show FOXO3 Antibodies)-3a/FBXO-dependent increase in BK-beta(1) degradation.
The study verified that the BK(Ca) channel alpha-subunit (show POLG Antibodies) is located to smooth muscle cells of porcine basilar and middle cerebral arteries.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.
calcium-activated potassium channel subunit beta-1
, calcium-activated potassium channel beta subunit
, potassium large conductance calcium-activated channel, subfamily M, beta member 1
, BK channel beta subunit
, BK channel subunit beta-1
, calcium-activated potassium channel subunit beta
, calcium-activated potassium channel, subfamily M subunit beta-1
, charybdotoxin receptor subunit beta-1
, maxi K channel subunit beta-1
, large conductance Ca2+-activated K+ channel beta 1 subunit
, calcium activated potassium channel beta subunit
, calcium activated potassium channel beta subunit protein
, calcium dependent potassium channel beta subunit protein
, large conductance Ca2+-activated K+ channel beta1 subunit
, large conductance calcium-activated potassium channel beta subunit
, large conductance calcium-activated potassium channel beta1 subunit
, maxi-K channel beta subunit