PSG2 Proteins

Protein Summary

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994

Gene names and symbols associated with PSG2

• pregnancy specific beta-1-glycoprotein 2 (PSG2) antibody

• CEA antibody
• PSBG2 antibody
• PSG1 antibody

Protein level used designations for PSG2

PS-beta-E , PS-beta-G-2 , PSBG-2 , carcinoembryonic antigen SG8 , pregnancy-specific beta-1 glycoprotein E , pregnancy-specific beta-1-glycoprotein 2 , pregnancy-specific beta-1-glycoprotein 7 , pregnancy-specific beta-1-glycoprotein-2 , pregnancy-specific glycoprotein 2