POF1B Proteins

Protein Summary

Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.

Gene names and symbols associated with POF1B

• POF1B, actin binding protein (Pof1b) antibody
• premature ovarian failure 1B (Pof1b) antibody
• POF1B, actin binding protein (POF1B) antibody

• 2310066B14Rik antibody
• POF antibody
• POF2B antibody
• RGD1560798 antibody

Protein level used designations for POF1B

protein POF1B , premature ovarian failure protein 1B