Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 Proteins (PDSS2)

The protein encoded by PDSS2 is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. Additionally we are shipping PDSS2 Antibodies (77) and PDSS2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDSS2 57107 Q86YH6
Rat PDSS2 PDSS2 365592 Q5U2R1
PDSS2 71365 Q33DR3
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Top PDSS2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$554.07
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Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 60 to 71 Days
$2,777.50
Details

PDSS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 (PDSS2) Interaction Partners

Human Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 (PDSS2) interaction partners

  1. PDSS2 encodes a putative tumor suppressor, and its expression is regulated by hypermethylation of its promoter in gastric cancer cells.

  2. Decreased PDSS2 expression is an unfavorable prognostic factor for hepatocellular carcinoma, and PDSS2 has potent anticancer activity in HCC (show FAM126A Proteins) tissues and HepG2 cells.

  3. Decreased PDSS2 mRNA levels were detected in HCC (show FAM126A Proteins) tissues of 56 patients, correlated with shorter disease-specific survival, and was identified as an independent prognostic factor

  4. PDSS2 has tumor-suppressing activity in human lung cancer cells by enhancing apoptosis and inhibiting tumorigenic capacity.

  5. Human PDSS2 polymorphisms are associated with podocyte diseases. A deficiency of coenzyme Q10 (show EIF2C2 Proteins) is manifested in lymphoblastoid cell lines derived from focal segmental glomerulosclerosis patients.

  6. Loss of PDSS2 expression is associated with non-small cell lung cancer.

  7. Data show that expression of either dlp1 or dps1 recovered the thermo-sensitive growth of an E. coli ispB(R321A) mutant and restored IspB activity and production of Coenzyme Q-8.

  8. murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (show PDSS1 Proteins) (mSPS1 (show PDSS1 Proteins)) and hDLP1 (mDLP1).

  9. Expression of PDSS2 is downregulated in human gastric cancer. PDSS2 may be a potent gastric cancer growth suppressor in vitro acting through apoptosis pathways.

Mouse (Murine) Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 (PDSS2) interaction partners

  1. kidney-specific loss of mitochondria triggered by oxidative stress may be the cause of renal failure in Pdss2(kd/kd) mice

  2. During cerebellum development, Pdss2 knockout results in severe cerebellum hypoplasia by impairing cell migration and eliciting ectopic apoptosis, whereas Pdss2 knockout in Purkinje cells at postnatal stages leads to the development of cerebellar ataxia.

  3. Data show that focal segmental glomerulopathy-like kidney disease in Pdss2 mutant animals with primary coenzyme Q (CoQ) deficiency is significantly ameliorated by oral treatment with probucol.

  4. kd is mutant allele of novel gene for prenyltransferase-like mitochondrial protein (PLMP). Alternatively spliced. Larger gene product has one domain resembling transprenyltransferase and another similar to geranylgeranyl pyrophosphate synthase (show GGPS1 Proteins). (PLMP)

  5. murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (show PDSS1 Proteins) (mSPS1 (show PDSS1 Proteins)) and hDLP1 (mDLP1 (show PDSS1 Proteins)).

  6. a presumed autoimmune kidney disease in mice with the missense Pdss2(kd/kd) genotype can be attributed to a mitochondrial CoQ biosynthetic defect

  7. Dietary supplementation with coenzyme Q10 (show H2-Q10 Proteins) provides a dramatic rescue of both proteinuria and interstitial nephritis in the Pdss2kd/kd mutant mice.

PDSS2 Protein Profile

Protein Summary

The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.

Gene names and symbols associated with PDSS2

  • decaprenyl diphosphate synthase subunit 2 (PDSS2)
  • prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2)
  • decaprenyl diphosphate synthase subunit 2 (pdss2)
  • decaprenyl-diphosphate synthase subunit 2 (CpipJ_CPIJ016311)
  • decaprenyl diphosphate synthase subunit 2 Dlp1 (SJAG_01865)
  • decaprenyl-diphosphate synthase subunit 2 (Tsp_08290)
  • prenyl (decaprenyl) diphosphate synthase, subunit 2 (pdss2)
  • decaprenyl diphosphate synthase subunit 2 (Pdss2)
  • prenyl (solanesyl) diphosphate synthase, subunit 2 (Pdss2)
  • 5430420P03Rik protein
  • bA59I9.3 protein
  • C6orf210 protein
  • COQ10D3 protein
  • DLP1 protein
  • Gm60 protein
  • hDLP1 protein
  • kd protein
  • mDLP1 protein
  • Plmp protein
  • zgc:92156 protein

Protein level used designations for PDSS2

prenyl (decaprenyl) diphosphate synthase, subunit 2 , prenyl diphosphate synthase, subunit 2 , decaprenyl-diphosphate synthase subunit 2 , decaprenyl-diphosphate synthase subunit 2-like , all-trans-decaprenyl-diphosphate synthase subunit 2 , decaprenyl pyrophosphate synthase subunit 2 , decaprenyl pyrophosphate synthetase subunit 2 , subunit 2 of decaprenyl diphosphate synthase , prenyl (decaprenyl) diphosphate synthase subunit 2 , prenyl (solanesyl) diphosphate synthase, subunit 2 , prenyltransferase-like mitochondrial protein , solanesyl-diphosphate synthase subunit 2

GENE ID SPECIES
100072062 Equus caballus
421777 Gallus gallus
462912 Pan troglodytes
493532 Xenopus (Silurana) tropicalis
6049785 Culex quinquefasciatus
7048046 Schizosaccharomyces japonicus yFS275
10905715 Trichinella spiralis
100405832 Callithrix jacchus
57107 Homo sapiens
436624 Danio rerio
100312977 Sus scrofa
521115 Bos taurus
365592 Rattus norvegicus
481950 Canis lupus familiaris
71365 Mus musculus
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