Progestin and AdipoQ Receptor Family Member III Proteins (PAQR3)

Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.. Additionally we are shipping PAQR3 Antibodies (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAQR3 152559 Q6TCH7
PAQR3 231474 Q6TCG8
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Top PAQR3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details

PAQR3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Progestin and AdipoQ Receptor Family Member III (PAQR3) Interaction Partners

Human Progestin and AdipoQ Receptor Family Member III (PAQR3) interaction partners

  1. Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of hepatic PPARalpha in response to starvation.

  2. Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway

  3. that PAQR3 can be a promising methylation marker candidate for the detection and monitoring of prostate cancer

  4. PAQR3 is epigenetically silenced in esophageal squamous cell carcinoma (ESCC) and restoration of PAQR3 suppresses the aggressive phenotype of ESCC cells

  5. Low expression of PAQR3 is associated with gastric cancer metastasis.

  6. Data suggest that expression of PAQR3 is down-regulated in glioma tissues and cell lines; PAQR3 overexpression suppresses cell migration of glioma cells, suppresses invasivness of glioma in xenograft experiments, and prevents epithelial-mesenchymal transition.

  7. our study pinpoints that PAQR3 functions as an adaptor protein to promote Nrf2-Keap1 complex formation, thereby modulating the Nrf2-Keap2 pathway and playing an important role in controlling antioxidant response of the cell

  8. This finding reveals a new mode of regulation of mTORC1 signaling and autophagy by PAQR3 in response to alterations of amino acids.

  9. we demonstrated that overexpression of PAQR3 suppresses cell proliferation, migration, and invasion in esophageal cancer in vitro and in vivo.

  10. The expression of PAQR3 protein significantly decreased in lung cancer.

  11. our results suggested that the aberrant methylation of PAQR3 underlies its downregulation in breast cancer and our data indicated that epigenetic silencing of PAQR3 gene expression by promoter hypermethylation may play an important role in breast cancer

  12. PAQR3 plays a tumor suppressive role in laryngeal squamous cell carcinoma

  13. A novel role for the newly characterized, Golgi-localized PAQR3 in regulating heterotrimeric G-proteins at the non-canonical subcellular location of the Golgi.

  14. findings not only pinpoint that Twist1 mediates the modulatory function of PAQR3 on EMT and metastasis but also suggest that targeting Twist1 is a promising strategy to control metastasis of tumors with downregulation of PAQR3

  15. PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.

  16. Our data indicate that PAQR3 functions as a tumor suppressor in the development of human breast cancers.

  17. DDB2 is involved in ubiquitination and degradation of PAQR3 in gastric cancer cells.

  18. PAQR3 is markedly down-regulated in human gastric cancers. PAQR3 expression level is closely associated with the progression and metastasis of gastric cancers

  19. PAQR3 might act as a tumor suppressor in osteosarcoma.

  20. PAQR3 may play an important role in the progression of hepatocellular carcinoma and serve as a potential candidate for the targeted therapy of hepatocellular carcinoma

Mouse (Murine) Progestin and AdipoQ Receptor Family Member III (PAQR3) interaction partners

  1. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity

  2. PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.

  3. This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling.

  4. PAQR3 negatively regulates insulin signaling by shunting cytosolic p110alpha to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110alpha.

  5. Loss of PAQR3 is associated with tumorigenesis of colorectal cancers.

  6. reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway.

  7. RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin.

PAQR3 Protein Profile

Protein Summary

Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.

Gene names and symbols associated with PAQR3

  • progestin and adipoQ receptor family member 3 (PAQR3)
  • progestin and adipoQ receptor family member III (Paqr3)
  • 6330415A20Rik protein
  • AY424292 protein
  • RKTG protein

Protein level used designations for PAQR3

Raf kinase trapping to Golgi , progestin and adipoQ receptor family member 3

GENE ID SPECIES
152559 Homo sapiens
231474 Mus musculus
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