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Binds to F-actin. Additionally we are shipping Proline-serine-threonine Phosphatase Interacting Protein 2 Proteins (3) and many more products for this protein.
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PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1 (show GATA1 Antibodies)-deficient megakaryocytes by activating LYN (show LYN Antibodies).
a new PSTPIP1 (show PSTPIP1 Antibodies)/PTPN6 (show PTPN6 Antibodies)/SHIP1 (show INPP5D Antibodies)/2-dependent negative feedback mechanism that counterbalances Src (show SRC Antibodies) and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption
SHIP1 (show INPP5D Antibodies) and Csk (show CSK Antibodies) are part of the PSTPIP2-dependent inhibitory network that prevents the development of autoinflammatory disease.
PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of SAPHO syndrome.
inflammasome-independent production of IL-1beta (show IL1B Antibodies) has a critical role in osteolytic bone disease; PSTPIP2 is a negative regulator of caspase-1 (show CASP1 Antibodies)-autonomous IL-1beta (show IL1B Antibodies) production
IL-1beta (show IL1B Antibodies) has a role in mediating autoinflammatory disease in Pstpip2-deficient mice
Knockdown of PSTPIP2 inmacrophages enhances the assembly of FBP17 (show FNBP1 Antibodies), leading to'hyperactivation' of actin nucleation at podosomes and ECM (show MMRN1 Antibodies) degradation.
PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.
our pstpip2 mutant mice provide a new model for investigating the potential mechanisms of inflammatory pain.
MAYP directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.
A missense mutation in pstpip2 is associated with the autoinflammatory disorder chronic multifocal osteomyelitis.
Binds to F-actin. May be involved in regulation of the actin cytoskeleton.
proline-serine-threonine phosphatase interacting protein 2
, proline-serine-threonine phosphatase-interacting protein 2
, similar to proline-serine-threonine phosphatase interacting protein 1
, proline-serine-threonine phosphatase-interacting protein 2-like
, PEST phosphatase-interacting protein 2
, macrophage actin-associated tyrosine-phosphorylated protein