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The protein encoded by PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. Additionally we are shipping PROCR Antibodies (180) and PROCR Proteins (37) and many more products for this protein.
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The activation of PAR-1 on the cell surface of SGC7901 and AGS (show JAG1 ELISA Kits) cells was significantly reduced after the knockdown of EPCR. By contrast, blockade of PAR-1 reduced the proliferation and migration of gastric cells in vitro
analysis of DC8 and DC13 PfEMP1 variants reveals that Plasmodium falciparum-infected erythrocytes-endothelial protein C receptor interaction may be prevented by plasma components under physiological conditions
Low EPCR expression is associated with meningococcal purpura fulminans.
Our findings suggested that breast cancer patients with expression of PROCR is more prone to suffer from distant metastasis and bad clinical outcomes.
Plasma levels of Ang2 (show ANGPT2 ELISA Kits) were associated with markers of malaria severity and levels of var transcripts encoding P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) containing Cysteine Rich Inter Domain Region alpha1 (CIDRalpha1) domains predicted to bind Endothelial Protein C receptor (EPCR).
The EPCR rs867186-GG genotype is associated with increased soluble protein, and it could mediate protection against severe malaria.
The data indicate that EPCR can regulate p63 (show RPE65 ELISA Kits), is associated with highly proliferative keratinocytes, and is a potential human epidermal stem cell marker.
Analysis of a cohort of breast cancer patients revealed an association of high EPCR levels with adverse clinical outcome. Interestingly, EPCR knockdown did not affect cell growth kinetics in 2D but reduced cell growth in 3D cultures. EPCR silencing reduced primary tumor growth and secondary outgrowths at metastatic sites. EPCR via SPOCK1 (show SPOCK1 ELISA Kits) confers a cell growth advantage in 3D promoting breast tumorigenesis and metastasis.
analysis of renal endothelial PROCR expression and shedding during diabetic nephropathy
EPCR occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 ELISA Kits), thereby inducing beta-arrestin-2 (show ARRB2 ELISA Kits) biased PAR1 signaling by both APC (show APC ELISA Kits) and thrombin (show F2 ELISA Kits). In
Leu8 (show SELL ELISA Kits) is crucial for FVIIa-EPCR binding; this study characterizes its interaction in vivo in mice
PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells.
Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization. aPC-EPCR-PAR1 signaling promotes HSC retention in bone marrow.
impaired EPCR/protein C (show PROC ELISA Kits)-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
sPLA2 (show PLA2G2A ELISA Kits)-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C (show PROC ELISA Kits) activation.
HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated.
The protein C receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS)-regulated gene expression.
Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo.
protein C (show PROC ELISA Kits) receptor (Procr), a novel Wnt (show WNT2 ELISA Kits) target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells
FVIIa binding to EPCR leads to a barrier protective effect in vivo
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
protein C receptor, endothelial (EPCR)
, APC receptor
, CD201 antigen
, activated protein C receptor
, cell cycle, centrosome-associated protein
, endothelial protein C receptor
, endothelial cell protein C receptor
, CD antigen CD201
, centrosomal protein CCD41
, endothelial cell protein C/activated protein C