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PPP1R1B encodes a bifunctional signal transduction molecule.
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DARPP-32 and I-1 were most frequently identified in dendritic shafts, unlike the D1R (show DRD1 Proteins) and PP1 isoforms. Moreover, DARPP-32 and I-1 were only present in approximately 4% and 8% of area 9 pyramidal cell spines, respectively.
t-Darpp phosphorylation at T39 seems to be crucial for t-Darpp-mediated PKA activation and this activation appears to occur through an association with RI and sequestering of RI away from PKAc. The t-Darpp-RI interaction could be a druggable target to reduce PKA activity in drug-resistant cancer.
our results lend support for a potential role of DARPP-32 genetic variants in neural response to potential reward triggering cues
To facilitate live-cell identification, a human embryonic stem cell line was generated using CRISPR-mediated gene editing at the DARPP32 locus.
Study associates polymorphisms in DRD2 (show DRD2 Proteins), DARPP-32, and COMT (show COMT Proteins) genes with novel category learning performance. Modeling results suggest that striatal dopaminergic genes influence selective attention processes whereas cortical genes mediate the ability to update complex rule representations.
Results show that expression of human DARPP-32 protein isoforms depends on the striatal neurodevelopmental stage with t-DARPP being specific for the human adult striatum.
In vivo xenograft models demonstrated that overexpression of DARPP-32 promotes angiogenesis and tumour growth.
This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.
DARPP-32 is mainly cleaved at Thr (show TRH Proteins)(153) by calpain and this cleavage of DARPP-32 reduces CREB (show CREB1 Proteins) phosphorylation via loss of its inhibitory function on PP1 (show PPA1 Proteins); results suggest a novel mechanism of DARPP-32-CREB (show CREB1 Proteins) signalling dysregulation in Alzheimer's disease
No significant differences in mRNA expression levels of DRD2 (show DRD2 Proteins) and DARPP-32 were found among controls, patients with psychotic disorder not otherwise specified, and schizophrenia/schizophreniform disorder.
Striatal function was indexed by a gene coding for DARPP-32, which is densely expressed in the striatum where it is necessary for synaptic plasticity
the results suggest that by inducing dephosphorylation of DARPP-32 at Ser (show SIGLEC1 Proteins)-97 and altering its cytonuclear distribution, glutamate (show GRIN1 Proteins) may counteract dopamine/D1 receptor (show DRD1 Proteins)/PKA signaling at multiple cellular levels.
Darpp32 interaction with beta-adducin (show ADD2 Proteins) may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.
Results show that Darpp-32 was expressed in normal mouse mammary tissue and in some breast tumors, whereas t-Darpp was found exclusively in mammry tumors.
analysis of cAMP-activated DARPP-32 signalling to the nucleus
Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 (show TSC1 Proteins) with a Darpp32-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas.
Cannabinoid-stimulated G-protein activity did not differ between DARPP-32 KO and WT mice treated with vehicle or repeated THC.
In this work, the dissected postsynaptic topology of the DARPP-32 phosphoprotein provides strong evidence for a compartmentalized and confined distribution in dendritic spines.
Adenosine AA receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.
Data suggest that histone deacetylase (show HDAC1 Proteins) inhibitors inhibit the induction of NGF1A-binding protein (show NAB1 Proteins) Nab2 (show NAB2 Proteins) by brain derived neurotrophic factor (BDNF (show BDNF Proteins)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein (show ARPP21 Proteins), 32 kDa (DARPP-32).
Areas of brain and spinal cord that are densely innervated by tyrosine hydroxylase (show TH Proteins)-immunoreactive fibers display a remarkable immunoreactivity for DARPP-32/ppp1r1b in cell bodies and neuropil.
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
, neuronal phosphoprotein DARPP-32
, protein phosphatase 1 regulatory subunit 1B
, protein phosphatase 1, regulatory (inhibitor) subunit 1B
, dopamine- and cAMP-regulated neuronal phosphoprotein
, dopamine- and cAMP-regulated phosphoprotein DARPP-32
, dopamine and cAMP-regulated neuronal phosphoprotein 32
, dopamine and cAMP regulated