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Protein Tyrosine Phosphatase F Interacting Protein 1 Proteins (PPFIA1)

The protein encoded by PPFIA1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family.

list all proteins Gene Name GeneID UniProt
Human PPFIA1 PPFIA1 8500 Q13136
Mouse PPFIA1 PPFIA1 233977  
Rat PPFIA1 PPFIA1 293645  
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Top Protein Tyrosine Phosphatase F Interacting Protein 1 Proteins at antibodies-online.com

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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
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More Proteins for Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Interaction Partners

Human Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) interaction partners

  1. Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor (show ESR1 Proteins)+/N- breast cancer, but not in estrogen receptor (show ESR1 Proteins)+/N+ or estrogen receptor (show ESR1 Proteins)- patients.

  2. These results indicate that liprin-alpha1 localizes to different adhesion and cytoskeletal structures to regulate vimentin (show VIM Proteins) intermediate filament network, thereby altering the invasion and growth properties of the cancer cells.

  3. The human tumor cell line MDA-MB-231 expresses liprin-alpha 1 and is able to promote the formation of metastasis in mice.

  4. results suggested that PPFIA1 functioned with PP2A (show PPP2R4 Proteins) to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli (show GLI1 Proteins) transcriptional activity.

  5. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge

  6. PPFIA1 was frequently co-amplified with the Cyclin D1 (show CCND1 Proteins) gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy.

  7. PPFIA1 as a potential functional candidate acute lung injury risk gene

  8. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions

  9. These results suggest that an increased expression of Liprin-alpha1 in the brain may be associated with human Intractable epilepsy .

  10. Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions.

Mouse (Murine) Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) interaction partners

  1. findings collectively demonstrate that the Cdk5 (show CDK5 Proteins)-dependent phosphorylation of liprinalpha1 is important for the postsynaptic organization during activity-dependent synapse development.

  2. results suggested that PPFIA1 functioned with PP2A (show PPP2R2B Proteins) to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli (show GLI1 Proteins) transcriptional activity.

Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PPFIA1

  • PTPRF interacting protein alpha 1 (PPFIA1)
  • protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (Ppfia1)
  • PTPRF interacting protein alpha 1 (Ppfia1)
  • C030014K08Rik protein
  • C87158 protein
  • LIP.1 protein
  • LIP1 protein
  • LIPRIN protein

Protein level used designations for PPFIA1

LAR-interacting protein 1 , LIP-1 , Liprin-alpha1 , PTPRF-interacting protein alpha-1 , liprin-alpha-1 , protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 , liprin , protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein, alpha 1

GENE ID SPECIES
8500 Homo sapiens
233977 Mus musculus
293645 Rattus norvegicus
475999 Canis lupus familiaris
100139635 Bos taurus
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