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PCDH11 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping Protocadherin 11 Antibodies (30) and many more products for this protein.
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PCDH11X, expressed in brain is implicated in cell-cell communication, verbal ability, cerebral asymmetry, and dendritic synaptic plasticity, may be regarded as a new candidate gene for dyslexia.
PCDH11X expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive.
the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens
our data...failed to confirm the association between PCDH11X polymorphisms and late-onset Alzheimer's disease
An association between late-onset Alzheimer disease and the PCDH11X polymorphisms, was not detected.
PCDH11X gene polymorphism does not play a major role in the genetic predisposition to late-onset Alzheimer disease in this Han Chinese population.
association not found for rs5984894 polymorphism in PCDH11X in Alzheimer's disease in Italy
The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes.
By confirming the suspected lack of X-Y homologous status for PCDH11 in non-human primates, our results reinforce the hypothesis of a hominid-specific role for this gene in brain development
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
Overexpression of wild-type Pcdh11x reduced dendritic complexity, whereas knockdown of Pcdh11x increased dendritic branching.
Pcdh11x decreased neural differentiation but increased the neural proliferation.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with variable cytoplasmic domains.
, protocadherin on the X chromosome
, protocadherin-11 X-linked
, protocadherin X-linked 11
, protocadherin 11 X-linked
, protocadherin 11 Y-linked
, Protocadherin-11 X-linked