Pyridoxamine 5'-Phosphate Oxidase Proteins (PNPO)

The enzyme encoded by PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Additionally we are shipping PNPO Antibodies (86) and PNPO Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNPO 55163 Q9NVS9
PNPO 64533 O88794
PNPO 103711 Q91XF0
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Top PNPO Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human PNPO Protein. 100 μg Log in to see 11 to 18 Days
$540.11
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse PNPO Protein. 100 μg Log in to see 11 to 18 Days
$611.18
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,674.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,674.83
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$3,655.38
Details

PNPO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

More Proteins for Pyridoxamine 5'-Phosphate Oxidase (PNPO) Interaction Partners

Human Pyridoxamine 5'-Phosphate Oxidase (PNPO) interaction partners

  1. TGF-beta1 (show TGFB1 Proteins)-mediated PNPO expression was at least in part through the upregulation of miR (show MLXIP Proteins)-143-3p in epithelial ovarian cancer.

  2. data support a pathogenic role of the c.347G>A (p.Arg116Gln) mutation in PNPO deficiency; the later onset of symptoms and the milder epilepsy phenotype of these expand the disease phenotype

  3. Exome sequencing revealed that the patient was compound heterozygous for pathogenic mutations [c.546+1G>A (IVS5+1 G>A) and c.620delG (p.G207VfsX215)] in the PNPO gene.

  4. One sequence variant, R116Q, a single nucleotide polymorphism that has been reported in the general population, was found to have an effect on PNPO activity.

  5. Challenge to the paradigm of exclusive PLP (show PLP1 Proteins) responsiveness in patients with pyridoxal 5'-phosphate oxidase deficiency and underlines the importance of consecutive testing of pyridoxine and PLP (show PLP1 Proteins) in neonates with antiepileptic drug-resistant seizures.

  6. Generalized epilepsies implicates susceptibility genes: CHRM3 (show CHRM3 Proteins) at 1q43, VRK2 (show VRK2 Proteins) at 2p16.1, ZEB2 (show ZEB2 Proteins) at 2q22.3, SCN1A (show SCN1A Proteins) at 2q24.3 and PNPO at 17q21.32.

  7. provide evidence that a single arginine residue of the C terminus of pyridoxal 5'-phosphate synthase is responsible for coordinating co-operativity in this elaborate protein machinery

  8. Results describe a combined computer and biochemical approach to characterize human pyridoxine 5'-phosphate oxidase (PNPO).

  9. We examined 8 single nucleotide polymorphisms (SNPs) in PNPO and its 5'-flanking regions in 359 schizophrenia patients and 582 control subjects.

  10. Sequencing of the PNPO gene revealed a novel homozygous nonsense mutationt in exon 3 in the neonatal and infantile seizure.

PNPO Protein Profile

Protein Summary

The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.

Gene names and symbols associated with PNPO

  • pyridoxamine 5'-phosphate oxidase (pnpo)
  • pyridoxine 5'-phosphate oxidase (pdxH)
  • pyridoxamine 5'-phosphate oxidase (Mrub_2888)
  • pyridoxamine 5'-phosphate oxidase (Arnit_1624)
  • pyridoxamine 5'-phosphate oxidase (Ndas_4168)
  • pyridoxamine 5'-phosphate oxidase (Mesil_2817)
  • Pyridoxamine 5'-phosphate oxidase (Isop_0296)
  • Pyridoxamine 5'-phosphate oxidase (Despr_1960)
  • Pyridoxamine 5'-phosphate oxidase (Pedsa_1348)
  • pyridoxamine 5'-phosphate oxidase (Mesop_5639)
  • pyridoxamine 5'-phosphate oxidase (PNPO)
  • pyridoxamine 5'-phosphate oxidase (Pnpo)
  • pyridoxine 5'-phosphate oxidase (Pnpo)
  • AI415282 protein
  • ECK1634 protein
  • im:7138360 protein
  • JW1630 protein
  • PDXPO protein

Protein level used designations for PNPO

pyridoxine-5'-phosphate oxidase , pyridoxamine 5'-phosphate oxidase , Pyridoxamine 5'-phosphate oxidase , pyridoxal 5'-phosphate synthase , pyridoxamine-phosphate oxidase , pyridoxine 5'-phosphate oxidase , pyridoxine 5-phosphate oxidase

GENE ID SPECIES
402868 Danio rerio
946806 Escherichia coli str. K-12 substr. MG1655
8881004 Meiothermus ruber DSM 1279
9171784 Arcobacter nitrofigilis DSM 7299
9248042 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9252339 Meiothermus silvanus DSM 9946
10154400 Isosphaera pallida ATCC 43644
10174688 Desulfobulbus propionicus DSM 2032
10230903 Pedobacter saltans DSM 12145
10829504 Mesorhizobium opportunistum WSM2075
55163 Homo sapiens
480540 Canis lupus familiaris
512573 Bos taurus
64533 Rattus norvegicus
103711 Mus musculus
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