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In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. Additionally we are shipping RAB35 Antibodies (87) and RAB35 Proteins (7) and many more products for this protein.
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The authors propose that Rab35-GTP is a critical regulator of autophagy through recruiting autophagy receptor NDP52.
The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion.
The involvement of Rab35 in diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F-actin, both on endosomes and at the plasma membrane[review].
Data suggest that Rab35, interacting with TBC1D10A, functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2 (show CA2 ELISA Kits)+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 and Arf6 (show ARF6 ELISA Kits). (Rab35 = rab GTP-binding protein 53 (show IGFBP3 ELISA Kits); TBC1D10A = TBC1 domain family member 10A; ACAP2 = centaurin beta2; Arf6 (show ARF6 ELISA Kits) = ADP-ribosylation factor 6 (show ARF6 ELISA Kits))
Short-term EGF (show EGF ELISA Kits) stimulation if of lung tumor cells can increase the interaction between RUSC2 (show RUSC2 ELISA Kits) and GIT2 (show GIT2 ELISA Kits), prolonged stimulation leads to a decrease of their interaction through activating Rab35.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 (show ARF6 ELISA Kits) and Rab35 during infection.
Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.
Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes.
the activation-inactivation cycles of Rab35 and ARF6 (show ARF6 ELISA Kits) are required for the uptake of zymosan and that ACAP2 is an important component that links Rab35/ARF6 (show ARF6 ELISA Kits) signaling during phagocytosis of zymosan.
Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K/AKT signaling, suppress apoptosis, and transform cells in a PI3K-dependent manner.
This study demonstrated that Rab35 regulates Cdc42 (show CDC42 ELISA Kits) activity in neurons.
The Rab35 plays an important role in spindle organization and morphology maintenance, and thus meiotic nuclear maturation.
Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.
Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis.
The minimal functional Rab35-binding site of RUSC2 (show RUSC2 ELISA Kits) was identified at the amino acid residues 982-1199 and succeeded in developing a novel GTP (show AK3 ELISA Kits)-Rab35-specific trapper.
Rab35 colocalizes with actin filaments and with Cdc42 (show CDC42 ELISA Kits), Rac1 (show RAC1 ELISA Kits) and RhoA (show RHOA ELISA Kits), and that Rab35 can activate Cdc42 (show CDC42 ELISA Kits) both in vivo and in vitro
study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin (show FSCN1 ELISA Kits), which directly associated with active Rab35
In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.
RAB35, member RAS oncogene family
, ras-related protein Rab-35
, GTP-binding protein RAY
, ras-related protein rab-1c (GTP-binding protein ray)